Early life adversity as a risk factor for cognitive impairment and Alzheimer’s disease

[1]  Quanguang Zhang,et al.  Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity , 2023, Theranostics.

[2]  Bocong Yuan,et al.  Longstanding health risk across the life course: The influence of early-life experience on health status throughout the life span. , 2022, Journal of biosocial science.

[3]  Yong Tang,et al.  Stress-induced myelin damage in the hippocampal formation in a rat model of depression. , 2022, Journal of psychiatric research.

[4]  Renée C. Waters,et al.  Early Life Adversity and Neuropsychiatric Disease: Differential Outcomes and Translational Relevance of Rodent Models , 2022, Frontiers in Systems Neuroscience.

[5]  Jing Zhang,et al.  Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain , 2022, Nutrients.

[6]  S. Tsirka,et al.  Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination , 2022, Molecular Psychiatry.

[7]  Wei-yang Sun,et al.  Inhibition of Adult Hippocampal Neurogenesis Plays a Role in Sevoflurane-Induced Cognitive Impairment in Aged Mice Through Brain-Derived Neurotrophic Factor/Tyrosine Receptor Kinase B and Neurotrophin-3/Tropomyosin Receptor Kinase C Pathways , 2022, Frontiers in Aging Neuroscience.

[8]  M. Tremblay,et al.  Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses , 2022, Cell reports.

[9]  R. Zafonte,et al.  Association of Adverse Childhood Experiences With Poor Neuropsychiatric Health and Dementia Among Former Professional US Football Players , 2022, JAMA network open.

[10]  Quanguang Zhang,et al.  Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease , 2022, GeroScience.

[11]  Nastassia J Hajal,et al.  Conceptualizing Emotion Regulation and Coregulation as Family-Level Phenomena , 2022, Clinical child and family psychology review.

[12]  K. Ye,et al.  Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation , 2022, Gut.

[13]  Wei Zhang,et al.  Adverse Childhood Experiences and Mild Cognitive Impairment in Later Life: Exploring Rural/Urban and Gender Differences Using CHARLS , 2021, Journal of applied gerontology : the official journal of the Southern Gerontological Society.

[14]  Vrinda Kalia,et al.  Adverse childhood experiences (ACEs) associated with reduced cognitive flexibility in both college and community samples , 2021, PloS one.

[15]  L. Jennings,et al.  The Association Between Adverse Childhood Experiences and Positive Dementia Screen in American Older Adults , 2021, Journal of General Internal Medicine.

[16]  M. Oh,et al.  Transplantation of gut microbiota derived from Alzheimer’s disease mouse model impairs memory function and neurogenesis in C57BL/6 mice , 2021, Brain, Behavior, and Immunity.

[17]  J. Fichna,et al.  The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders. , 2021, Pharmacological research.

[18]  Peiyuan Qiu,et al.  The influence of childhood adversities on mid to late cognitive function: From the perspective of life course , 2021, PloS one.

[19]  S. Ryu,et al.  Disease Burdens of Alzheimer's Disease, Vascular Dementia, and Mild Cognitive Impairment. , 2021, Journal of the American Medical Directors Association.

[20]  S. Laws,et al.  Chronic stress and Alzheimer's disease: the interplay between the hypothalamic–pituitary–adrenal axis, genetics and microglia , 2021, Biological reviews of the Cambridge Philosophical Society.

[21]  J. Sáez,et al.  Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress , 2021, Advanced science.

[22]  Xinyan Han,et al.  Early-Life Intervention Using Exogenous Fecal Microbiota Alleviates Gut Injury and Reduce Inflammation Caused by Weaning Stress in Piglets , 2021, Frontiers in Microbiology.

[23]  J. Chan,et al.  Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease , 2021, Neuron.

[24]  M. Cunningham,et al.  Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL‐1β drives amplified responses in primed astrocytes and neuronal network dysfunction , 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[25]  B. Naliboff,et al.  Early life adversity predicts brain-gut alterations associated with increased stress and mood , 2021, Neurobiology of Stress.

[26]  Qiaoqin Wan,et al.  Comparative efficacy of various exercise interventions on cognitive function in patients with mild cognitive impairment or dementia: A systematic review and network meta-analysis , 2021, Journal of sport and health science.

[27]  K. Kondo,et al.  Adverse Childhood Experiences and Dementia: Interactions With Social Capital in the Japan Gerontological Evaluation Study Cohort. , 2021, American journal of preventive medicine.

[28]  M. Peeri,et al.  Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats , 2021, Pharmacology Biochemistry and Behavior.

[29]  Xuebo Liu,et al.  Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis , 2021, Brain, Behavior, and Immunity.

[30]  J. Jia,et al.  Gut Microbiota Changes and Their Correlation with Cognitive and Neuropsychiatric Symptoms in Alzheimer's Disease. , 2021, Journal of Alzheimer's disease : JAD.

[31]  A. Rábano,et al.  Evidences for Adult Hippocampal Neurogenesis in Humans , 2021, The Journal of Neuroscience.

[32]  V. Sheibani,et al.  Effects of short environmental enrichment on early‐life adversity induced cognitive alternations in adolescent rats , 2021, Journal of neuroscience research.

[33]  Jason M. Nagata,et al.  Adverse childhood events and cognitive function among young adults: Prospective results from the national longitudinal study of adolescent to adult health. , 2021, Child abuse & neglect.

[34]  T. Baram,et al.  Neurodevelopmental origins of substance use disorders: Evidence from animal models of early‐life adversity and addiction , 2021, The European journal of neuroscience.

[35]  Jong Woo Kim,et al.  Early-Life Stress Modulates Gut Microbiota and Peripheral and Central Inflammation in a Sex-Dependent Manner , 2021, International journal of molecular sciences.

[36]  Jun Peng,et al.  Gut Microbiome Features of Chinese Patients Newly Diagnosed with Alzheimer's Disease or Mild Cognitive Impairment. , 2021, Journal of Alzheimer's Disease.

[37]  Jun Wang,et al.  Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain , 2021, Gut microbes.

[38]  Ping Liu,et al.  Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay , 2021, Nutrients.

[39]  M. Hasegawa,et al.  Early-life stress induces the development of Alzheimer's disease pathology via angiopathy , 2020, Experimental Neurology.

[40]  I. Gotlib,et al.  The Social Ecology of Childhood and Early Life Adversity , 2020, Pediatric Research.

[41]  Y. Noam,et al.  Unexpected Transcriptional Programs Contribute to Hippocampal Memory Deficits and Neuronal Stunting after Early-Life Adversity , 2020, Cell reports.

[42]  M. Gunnar,et al.  Microbiota-immune alterations in adolescents following early life adversity: A proof of concept study. , 2020, Developmental psychobiology.

[43]  Xiaoming Hu.  Microglia/macrophage polarization: Fantasy or evidence of functional diversity? , 2020, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[44]  M. Bigdeli,et al.  Hypericin ameliorates maternal separation-induced cognitive deficits and hippocampal inflammation in rats. , 2020, Mini reviews in medicinal chemistry.

[45]  Zengqiang Yuan,et al.  Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice , 2020, Journal of Neuroinflammation.

[46]  F. Khodagholi,et al.  Early postnatal stress impairs insulin secretion in response to psychological stress in adult rats , 2020, Journal of Endocrinological Investigation.

[47]  Peter B. Jones,et al.  Childhood socio‐economic disadvantage predicts reduced myelin growth across adolescence and young adulthood , 2020, Human brain mapping.

[48]  E. Lunkenheimer,et al.  Understanding the parent-child coregulation patterns shaping child self-regulation. , 2020, Developmental psychology.

[49]  H. Baik,et al.  Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial , 2020, The journals of gerontology. Series A, Biological sciences and medical sciences.

[50]  N. Brydges,et al.  Environmental enrichment rescues survival and function of adult-born neurons following early life stress , 2020, Molecular Psychiatry.

[51]  N. Mastorakis,et al.  Stress-induced blood brain barrier disruption: molecular mechanisms and signaling pathways. , 2020, Pharmacological research.

[52]  Tae-Beom Seo,et al.  Effects of treadmill exercise on activity, short-term memory, vascular dysfunction in maternal separation rats , 2020, Journal of exercise rehabilitation.

[53]  Wu Enqi,et al.  Comparison of the Gut Microbiota Disturbance in Rat Models of Irritable Bowel Syndrome Induced by Maternal Separation and Multiple Early-Life Adversity , 2020, Frontiers in Cellular and Infection Microbiology.

[54]  J. Chan,et al.  Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory , 2020, Nature Neuroscience.

[55]  M. Kheirbek,et al.  Preservation of a remote fear memory requires new myelin formation , 2020, Nature Neuroscience.

[56]  K. Kondo,et al.  Association Between Adverse Childhood Experiences and Dementia in Older Japanese Adults. , 2020, JAMA network open.

[57]  N. Tottenham.  Early Adversity and the Neotenous Human Brain , 2020, Biological Psychiatry.

[58]  Nuria K. Mackes,et al.  Early childhood deprivation is associated with alterations in adult brain structure despite subsequent environmental enrichment , 2020, Proceedings of the National Academy of Sciences.

[59]  P. Mello-Carpes,et al.  Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment , 2020, Behavioural Brain Research.

[60]  D. Morris,et al.  Effects of early life adversity on immune function and cognitive performance: results from the ALSPAC cohort , 2020, Social Psychiatry and Psychiatric Epidemiology.

[61]  P. Lucassen,et al.  Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure , 2019, Journal of Neuroinflammation.

[62]  Andrew J. Mocle,et al.  Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice , 2019, Neuron.

[63]  Junrong Du,et al.  Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice , 2019, Acta pharmaceutica Sinica. B.

[64]  Christopher M. Jones,et al.  Identifying and Preventing Adverse Childhood Experiences: Implications for Clinical Practice. , 2020, JAMA.

[65]  Y. Kakinuma,et al.  Stress-induced microglial activation occurs through β-adrenergic receptor: noradrenaline as a key neurotransmitter in microglial activation , 2019, Journal of Neuroinflammation.

[66]  Tao Li,et al.  Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice , 2019, Neuroscience Bulletin.

[67]  E. Boda.  Myelin and oligodendrocyte lineage cell dysfunctions: New players in the etiology and treatment of depression and stress‐related disorders , 2019, The European journal of neuroscience.

[68]  L. Buée,et al.  NLRP3 inflammasome activation drives tau pathology , 2019, Nature.

[69]  Kieran Rea,et al.  The Microbiota-Gut-Brain Axis. , 2019, Physiological reviews.

[70]  Huidong Tang,et al.  Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota , 2019, Alzheimer's & Dementia.

[71]  T. Baram,et al.  Early-life adversity and neurological disease: age-old questions and novel answers , 2019, Nature Reviews Neurology.

[72]  I. Mook‐Jung,et al.  Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model , 2019, Gut.

[73]  M. Bertolotti,et al.  Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials , 2019, International journal of molecular sciences.

[74]  P. Gaspar,et al.  Early-life stress impairs postnatal oligodendrogenesis and adult emotional behaviour through activity-dependent mechanisms , 2019, Molecular Psychiatry.

[75]  Gary F. Temple,et al.  Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice , 2019, eLife.

[76]  N. Fox,et al.  Global deficits in executive functioning are transdiagnostic mediators between severe childhood neglect and psychopathology in adolescence , 2019, Psychological Medicine.

[77]  M. Joëls,et al.  Sex-Dependent Modulation of Acute Stress Reactivity After Early Life Stress in Mice: Relevance of Mineralocorticoid Receptor Expression , 2019, Front. Behav. Neurosci..

[78]  M. Leboyer,et al.  Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner , 2019, Brain, Behavior, and Immunity.

[79]  K. Bath,et al.  Limited Bedding and Nesting Induces Maternal Behavior Resembling Both Hypervigilance and Abuse , 2019, Front. Behav. Neurosci..

[80]  P. Lucassen,et al.  Treatment with the glutamate modulator riluzole prevents early life stress-induced cognitive deficits and impairments in synaptic plasticity in APPswe/PS1dE9 mice , 2019, Neuropharmacology.

[81]  L. D. de Souza,et al.  Alzheimer’s disease: risk factors and potentially protective measures , 2019, Journal of Biomedical Science.

[82]  Vanni Bucci,et al.  Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway , 2019, mBio.

[83]  Sudha Seshadri,et al.  Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis , 2019, BMJ.

[84]  A. Minihane,et al.  APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer’s disease pathophysiology , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[85]  R. Richardson,et al.  Early-life stress, microbiota, and brain development: probiotics reverse the effects of maternal separation on neural circuits underpinning fear expression and extinction in infant rats , 2019, Developmental Cognitive Neuroscience.

[86]  Jesús Ávila,et al.  Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease , 2019, Nature Medicine.

[87]  M. Liong,et al.  Lactobacillus paracasei PS23 reduced early-life stress abnormalities in maternal separation mouse model. , 2019, Beneficial microbes.

[88]  E. D. Leonardo,et al.  Early life stress delays hippocampal development and diminishes the adult stem cell pool in mice , 2019, Scientific Reports.

[89]  G. Kempermann.  Environmental enrichment, new neurons and the neurobiology of individuality , 2019, Nature Reviews Neuroscience.

[90]  W. Abraham,et al.  Environmental enrichment effects on synaptic and cellular physiology of hippocampal neurons , 2019, Neuropharmacology.

[91]  H. Tiemeier,et al.  Prenatal maternal psychopathology and stress and offspring HPA axis function at 6 years , 2019, Psychoneuroendocrinology.

[92]  P. Lucassen,et al.  Increasing availability of ω‐3 fatty acid in the early‐life diet prevents the early‐life stress‐induced cognitive impairments without affecting metabolic alterations , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[93]  Nicola J. Ray,et al.  Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis , 2019, Ageing Research Reviews.

[94]  Dan J Stein,et al.  Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 , 2019, The Lancet Neurology.

[95]  E. Mayer,et al.  The Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications , 2019, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[96]  A. El Hessni,et al.  Animal Models of Early-Life Adversity. , 2019, Methods in molecular biology.

[97]  L. Grinkevich,et al.  Stress early in life leads to cognitive impairments, reduced numbers of CA3 neurons and altered maternal behavior in adult female mice , 2018, Genes, brain, and behavior.

[98]  K. Walker.  Inflammation and neurodegeneration: chronicity matters , 2018, Aging.

[99]  P. Licona-Limón,et al.  Early life stress accelerates age-induced effects on neurogenesis, depression, and metabolic risk , 2018, Psychoneuroendocrinology.

[100]  E. Newcombe,et al.  Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease , 2018, Journal of Neuroinflammation.

[101]  Yong Cheng,et al.  Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis , 2018, Front. Immunol..

[102]  Eunhee Kim,et al.  Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model , 2018, Science.

[103]  T. Tuomainen,et al.  Association of childhood stress with late-life dementia and Alzheimer’s disease: the KIHD study , 2018, European journal of public health.

[104]  Huadong Zhou,et al.  Gut Microbiota is Altered in Patients with Alzheimer's Disease. , 2018, Journal of Alzheimer's disease : JAD.

[105]  S. Lightman,et al.  Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility , 2018, Stress.

[106]  Yuqin Ye,et al.  Sex differences in associations between maternal deprivation and alterations in hippocampal calcium-binding proteins and cognitive functions in rats , 2018, Behavioral and Brain Functions.

[107]  Nicholas M. Timme,et al.  Maternal deprivation induces alterations in cognitive and cortical function in adulthood , 2018, Translational Psychiatry.

[108]  F. Shahidi,et al.  Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits. , 2018, Annual review of food science and technology.

[109]  J. Gleeson,et al.  Early life experience shapes neural genome , 2018, Science.

[110]  S. Weggen,et al.  Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice , 2018, Translational Psychiatry.

[111]  F. Jessen,et al.  Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer’s disease , 2018, Alzheimer's Research & Therapy.

[112]  T. Smeeding,et al.  A Universal Child Allowance: A Plan to Reduce Poverty and Income Instability Among Children in the United States , 2018, RSF.

[113]  P. Lucassen,et al.  A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress , 2018, Neurobiology of Stress.

[114]  Qiu-qin Han,et al.  Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats , 2018, Journal of Neuroinflammation.

[115]  Y. Takatsuru,et al.  Early-life stress induces cognitive disorder in middle-aged mice , 2017, Neurobiology of Aging.

[116]  M. Rutter,et al.  HPA axis dysregulation in adult adoptees twenty years after severe institutional deprivation in childhood , 2017, Psychoneuroendocrinology.

[117]  W. D. de Vos,et al.  The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota , 2017, Microbiology and Molecular Biology Reviews.

[118]  H. Shair,et al.  Lasting effects of early life stress in mice: interaction of maternal environment and infant genes , 2017, Genes, brain, and behavior.

[119]  Sterling C. Johnson,et al.  Gut microbiome alterations in Alzheimer’s disease , 2017, Scientific Reports.

[120]  R. Cumming,et al.  Childhood Stress and Adversity is Associated with Late-Life Dementia in Aboriginal Australians. , 2017, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[121]  Tzong-Shiue Yu,et al.  Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition , 2017, Molecular Neurodegeneration.

[122]  B. Kolb,et al.  Prenatal noise stress impairs HPA axis and cognitive performance in mice , 2017, Scientific Reports.

[123]  P. Lucassen,et al.  Early‐life stress diminishes the increase in neurogenesis after exercise in adult female mice , 2017, Hippocampus.

[124]  S. Salim,et al.  Behavioral and cognitive impact of early life stress: Insights from an animal model , 2017, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[125]  M. Bellis,et al.  The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. , 2017, The Lancet. Public health.

[126]  M. Meaney,et al.  Association of a History of Child Abuse With Impaired Myelination in the Anterior Cingulate Cortex: Convergent Epigenetic, Transcriptional, and Morphological Evidence. , 2017, The American journal of psychiatry.

[127]  P. Lucassen,et al.  Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer’s disease mouse model , 2017, Brain, Behavior, and Immunity.

[128]  R. Hen,et al.  Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood , 2017, Nature Reviews Neuroscience.

[129]  M. Colonna,et al.  Microglia Function in the Central Nervous System During Health and Neurodegeneration. , 2017, Annual review of immunology.

[130]  Fang Pan,et al.  Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain , 2017, Neural plasticity.

[131]  M. Joëls,et al.  Effects of early-life stress on cognitive function and hippocampal structure in female rodents , 2017, Neuroscience.

[132]  N. Jia,et al.  Maternal separation exacerbates Alzheimer’s disease-like behavioral and pathological changes in adult APPswe/PS1dE9 mice , 2017, Behavioural Brain Research.

[133]  Bao-Ming Li,et al.  Neonatal Maternal Separation Impairs Prefrontal Cortical Myelination and Cognitive Functions in Rats Through Activation of Wnt Signaling , 2016, Cerebral cortex.

[134]  Rob Knight,et al.  Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease , 2016, Cell.

[135]  K. Wawrowsky,et al.  Chronic peripheral inflammation, hippocampal neurogenesis, and behavior , 2016, Brain, Behavior, and Immunity.

[136]  Brian D. Boyd,et al.  Effects of early life stress on depression, cognitive performance and brain morphology , 2016, Psychological Medicine.

[137]  R. Grassi‐Oliveira,et al.  Cognitive impairment effects of early life stress in adolescents can be predicted with early biomarkers: Impacts of sex, experience, and cytokines , 2016, Psychoneuroendocrinology.

[138]  M. Hosseini,et al.  Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats , 2016, Physiology & Behavior.

[139]  Alon Chen,et al.  Genetic predisposition for high stress reactivity amplifies effects of early-life adversity , 2016, Psychoneuroendocrinology.

[140]  Alejandra Ochoa-Zarzosa,et al.  Maternal separation activates microglial cells and induces an inflammatory response in the hippocampus of male rat pups, independently of hypothalamic and peripheral cytokine levels , 2016, Brain, Behavior, and Immunity.

[141]  Tanya Narahari,et al.  Effects of early adolescent environmental enrichment on cognitive dysfunction, prefrontal cortex development, and inflammatory cytokines after early life stress. , 2016, Developmental psychobiology.

[142]  K. Hsu,et al.  Early life stress dampens stress responsiveness in adolescence: Evaluation of neuroendocrine reactivity and coping behavior , 2016, Psychoneuroendocrinology.

[143]  T. Dinan,et al.  Regulation of prefrontal cortex myelination by the microbiota , 2016, Translational Psychiatry.

[144]  Katie A. McLaughlin,et al.  Future Directions in Childhood Adversity and Youth Psychopathology , 2016, Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53.

[145]  T. Baram,et al.  Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome , 2016, Translational psychiatry.

[146]  T. Dinan,et al.  N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota , 2015, PloS one.

[147]  T. Dinan,et al.  n-3 PUFAs have beneficial effects on anxiety and cognition in female rats: Effects of early life stress , 2015, Psychoneuroendocrinology.

[148]  De-xiang Liu,et al.  Long-term effects of early adolescent stress: dysregulation of hypothalamic–pituitary–adrenal axis and central corticotropin releasing factor receptor 1 expression in adult male rats , 2015, Behavioural Brain Research.

[149]  I. Amit,et al.  Host microbiota constantly control maturation and function of microglia in the CNS , 2015, Nature Neuroscience.

[150]  M. López-Gallardo,et al.  The maternal deprivation animal model revisited , 2015, Neuroscience & Biobehavioral Reviews.

[151]  S. Lazic,et al.  Chronic early life stress alters developmental and adult neurogenesis and impairs cognitive function in mice , 2015, Hippocampus.

[152]  Melissa T. Merrick,et al.  Childhood adversity and adult chronic disease: an update from ten states and the District of Columbia, 2010. , 2015, American journal of preventive medicine.

[153]  Klaus-Armin Nave,et al.  Oligodendrocytes: Myelination and Axonal Support. , 2015, Cold Spring Harbor perspectives in biology.

[154]  Frances A Champagne,et al.  Early-Life Experience, Epigenetics, and the Developing Brain , 2015, Neuropsychopharmacology.

[155]  F. Khodagholi,et al.  Effect of early life stress on pancreatic isolated islets’ insulin secretion in young adult male rats subjected to chronic stress , 2015, Endocrine.

[156]  J. Pollock,et al.  A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood , 2014, Acta physiologica.

[157]  P. Vemuri,et al.  Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences , 2014, Clinical epidemiology.

[158]  R. Feldman,et al.  Maternal-Preterm Skin-to-Skin Contact Enhances Child Physiologic Organization and Cognitive Control Across the First 10 Years of Life , 2014, Biological Psychiatry.

[159]  F. LaFerla,et al.  Mifepristone Alters Amyloid Precursor Protein Processing to Preclude Amyloid Beta and Also Reduces Tau Pathology , 2013, Biological Psychiatry.

[160]  J. Morrison,et al.  The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course , 2013, Neuron.

[161]  J. Eriksson,et al.  Cognitive ability and decline after early life stress exposure , 2013, Neurobiology of Aging.

[162]  P. Scully,et al.  The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner , 2013, Molecular Psychiatry.

[163]  M. Ramírez,et al.  Effects of early maternal separation on biobehavioral and neuropathological markers of Alzheimer's disease in adult male rats. , 2013, Current Alzheimer research.

[164]  M. Ramírez,et al.  Maternal deprivation effects on brain plasticity and recognition memory in adolescent male and female rats , 2013, Neuropharmacology.

[165]  E. Nestler,et al.  Early Stress Evokes Age-Dependent Biphasic Changes in Hippocampal Neurogenesis, Bdnf Expression, and Cognition , 2013, Biological Psychiatry.

[166]  E. Sternberg,et al.  Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction , 2012, Annals of the New York Academy of Sciences.

[167]  Danielle Swanson,et al.  Omega-3 fatty acids EPA and DHA: health benefits throughout life. , 2012, Advances in nutrition.

[168]  E. Adkins-Regan,et al.  Deprivation of maternal care has long-lasting consequences for the hypothalamic–pituitary–adrenal axis of zebra finches , 2012, Proceedings of the Royal Society B: Biological Sciences.

[169]  F. Gage,et al.  Adult hippocampal neurogenesis and its role in Alzheimer's disease , 2011, Molecular Neurodegeneration.

[170]  W. Collins,et al.  Early roots of adult competence , 2011, International journal of behavioral development.

[171]  B. Kolb,et al.  Maternal separation altered behavior and neuronal spine density without influencing amphetamine sensitization , 2011, Behavioural Brain Research.

[172]  F. Holsboer,et al.  Forebrain CRF1 Modulates Early-Life Stress-Programmed Cognitive Deficits , 2011, The Journal of Neuroscience.

[173]  P. Rabins,et al.  Early parental death and remarriage of widowed parents as risk factors for Alzheimer disease: the Cache County study. , 2011, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[174]  Kelly A. Bordner,et al.  Functional Genomic and Proteomic Analysis Reveals Disruption of Myelin-Related Genes and Translation in a Mouse Model of Early Life Neglect , 2011, Front. Psychiatry.

[175]  D. Hedges,et al.  Early-life stress and cognitive outcome , 2011, Psychopharmacology.

[176]  G. Lynch,et al.  Hippocampal Dysfunction and Cognitive Impairments Provoked by Chronic Early-Life Stress Involve Excessive Activation of CRH Receptors , 2010, The Journal of Neuroscience.

[177]  Monique Ernst,et al.  Early-life stress is associated with impairment in cognitive control in adolescence: An fMRI study , 2010, Neuropsychologia.

[178]  R. Kessler,et al.  Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication II: associations with persistence of DSM-IV disorders. , 2010, Archives of general psychiatry.

[179]  S. Maier,et al.  Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide , 2010, Brain, Behavior, and Immunity.

[180]  B. Gómez-González,et al.  Altered functional development of the blood–brain barrier after early life stress in the rat , 2009, Brain Research Bulletin.

[181]  P. Scully,et al.  Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses , 2009, Biological Psychiatry.

[182]  Sara E. Rimm-Kaufman,et al.  Positive Mother–child Interactions in Kindergarten: Predictors of School Success in High School , 2008 .

[183]  C. Sandman,et al.  A novel mouse model for acute and long-lasting consequences of early life stress. , 2008, Endocrinology.

[184]  T. Olsson,et al.  Increased Saliva Cortisol Awakening Response in Patients with Mild Cognitive Impairment , 2007, Dementia and Geriatric Cognitive Disorders.

[185]  C. Nemeroff,et al.  Long‐term behavioural and molecular alterations associated with maternal separation in rats , 2007, The European journal of neuroscience.

[186]  M. Ramírez,et al.  Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats , 2007, Psychoneuroendocrinology.

[187]  J. D. McGaugh,et al.  Glucocorticoids Increase Amyloid-β and Tau Pathology in a Mouse Model of Alzheimer’s Disease , 2006, The Journal of Neuroscience.

[188]  R. Sege,et al.  Anticipatory Guidance and Violence Prevention: Results From Family and Pediatrician Focus Groups , 2006, Pediatrics.

[189]  G. Lynch,et al.  Mechanisms of Late-Onset Cognitive Decline after Early-Life Stress , 2005, The Journal of Neuroscience.

[190]  G. Richter-Levin,et al.  Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat. , 2005, The international journal of neuropsychopharmacology.

[191]  B. Ellenbroek,et al.  Early maternal deprivation retards neurodevelopment in Wistar rats , 2005, Stress.

[192]  Christian Mirescu,et al.  Early life experience alters response of adult neurogenesis to stress , 2004, Nature Neuroscience.

[193]  O. Lindvall,et al.  Inflammation is detrimental for neurogenesis in adult brain , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[194]  A. Schatzberg,et al.  Slowing the progression of cognitive decline in alzheimer’s disease using mifepristone , 2002, Journal of Molecular Neuroscience.

[195]  N. Baumann,et al.  Biology of oligodendrocyte and myelin in the mammalian central nervous system. , 2001, Physiological reviews.

[196]  A. Schore.  Effects of a secure attachment relationship on right brain development, affect regulation, and infant mental health , 2001 .

[197]  J. Day,et al.  Maternal care, hippocampal synaptogenesis and cognitive development in rats , 2000, Nature Neuroscience.

[198]  C. Plata-salamán,et al.  Inflammation and Alzheimer’s disease , 2000, Neurobiology of Aging.

[199]  D. Williamson,et al.  Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. , 1998, American journal of preventive medicine.

[200]  M. Le Moal,et al.  Prenatal Stress Induces High Anxiety and Postnatal Handling Induces Low Anxiety in Adult Offspring: Correlation with Stress-Induced Corticosterone Secretion , 1997, The Journal of Neuroscience.

[201]  S. Levine.  Stimulation in infancy. , 1960, Scientific American.

[202]  G. Briggs,et al.  Inapparent lymphocytic choriomeningitis infection in folic acid-deficient mice. , 1957, Science.