Epigenetic derepression of FKBP5 by aging and stress contributes to NF-ĸB-driven inflammation and cardiovascular risk
暂无分享,去创建一个
C. Gieger | Sonja Kunze | M. Waldenberger | B. Bradley | K. Ressler | J. Eriksson | B. Müller-Myhsok | J. Lahti | K. Räikkönen | E. Binder | S. Wahl | S. Lucae | K. Ladwig | R. Emeny | Alicia K. Smith | J. Arloth | T. Rein | J. Baumert | S. Iurato | A. Drake | A. Zannas | T. Carrillo-Roa | S. Röh | F. Hausch | N. Gassen | J. Pape | T. Wiechmann | M. Ködel | S. Martinelli | K. Hafner | M. Jia | Maria Roitman | A. Haehle | J. Eriksson | J. Eriksson
[1] Steve Horvath,et al. DNA methylation-based biomarkers and the epigenetic clock theory of ageing , 2018, Nature Reviews Genetics.
[2] R. von Känel,et al. Psychological Stress, Inflammation, and Coronary Heart Disease , 2017, Current Cardiology Reports.
[3] G. Chrousos,et al. Epigenetic programming by stress and glucocorticoids along the human lifespan , 2017, Molecular Psychiatry.
[4] G. Chrousos,et al. Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases , 2017, Neuroscience & Biobehavioral Reviews.
[5] Tom R. Gaunt,et al. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity , 2016, Nature.
[6] F. Holsboer,et al. Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation , 2016, Biological Psychiatry.
[7] L. Christiansen,et al. Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort. , 2016, International journal of epidemiology.
[8] Trey Ideker,et al. Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA. , 2016, Molecular cell.
[9] R. Valiathan,et al. Effects of Ageing on the Immune System: Infants to Elderly , 2016, Scandinavian journal of immunology.
[10] C. Bell,et al. The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling , 2016, Science Translational Medicine.
[11] Naomi R. Wray,et al. Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling , 2015, Genome Biology.
[12] V. Chopra,et al. Elevated baseline plasma IL-8 levels are an independent predictor of long-term all-cause mortality in patients with acute coronary syndrome. , 2015, Atherosclerosis.
[13] B. Bradley,et al. Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder , 2015, Translational Psychiatry.
[14] M. Peinado,et al. Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer , 2015, Epigenetics & Chromatin.
[15] M. Masullo,et al. FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma , 2015, Nucleic acids research.
[16] S. Ozanne,et al. Programming of cardiovascular disease across the life-course. , 2015, Journal of molecular and cellular cardiology.
[17] S. Arora,et al. Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis , 2015, British Journal of Cancer.
[18] Ivana V. Yang,et al. An Epigenome-Wide Association Study of Total Serum Immunoglobulin E Concentration , 2014, Nature.
[19] F. Holsboer,et al. Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans , 2014, PLoS medicine.
[20] T. Fall,et al. FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance. , 2014, Metabolism: clinical and experimental.
[21] G. Piwien-Pilipuk,et al. NF-κB Transcriptional Activity Is Modulated by FK506-binding Proteins FKBP51 and FKBP52 , 2014, The Journal of Biological Chemistry.
[22] Jean-Philippe Fortin,et al. shinyMethyl: interactive quality control of Illumina 450k DNA methylation arrays in R , 2014, F1000Research.
[23] Ira Tabas,et al. Inflammation and its Resolution as Determinants of Acute Coronary Syndromes , 2014, Circulation research.
[24] Rafael A. Irizarry,et al. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays , 2014, Bioinform..
[25] Guangyu Zhang,et al. Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies. , 2014, Atherosclerosis.
[26] William P. Accomando,et al. Quantitative reconstruction of leukocyte subsets using DNA methylation , 2014, Genome Biology.
[27] K. Hansen,et al. Functional normalization of 450k methylation array data improves replication in large cancer studies , 2014, Genome Biology.
[28] R. Irizarry,et al. Accounting for cellular heterogeneity is critical in epigenome-wide association studies , 2014, Genome Biology.
[29] S. Horvath. DNA methylation age of human tissues and cell types , 2013, Genome Biology.
[30] C. Cotman,et al. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. , 2013, The Journal of clinical investigation.
[31] Amit J. Shah,et al. Post-traumatic stress disorder and incidence of coronary heart disease: a twin study. , 2013, Journal of the American College of Cardiology.
[32] Margaret R Karagas,et al. Blood-based profiles of DNA methylation predict the underlying distribution of cell types , 2013, Epigenetics.
[33] Jing Wang,et al. WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013 , 2013, Nucleic Acids Res..
[34] A. S. Nateri,et al. The streptavidin/biotinylated DNA/protein bound complex protocol for determining the association of c-JUN protein with NANOG promoter. , 2013, Current protocols in stem cell biology.
[35] Ruth Pidsley,et al. A data-driven approach to preprocessing Illumina 450K methylation array data , 2013, BMC Genomics.
[36] B. Bradley,et al. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder , 2013, Proceedings of the National Academy of Sciences.
[37] J. Wysocka,et al. Modification of enhancer chromatin: what, how, and why? , 2013, Molecular cell.
[38] R. Weksberg,et al. Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray , 2013, Epigenetics.
[39] T. Costantino,et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a€review , 2012 .
[40] B. Bradley,et al. Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions , 2012, Nature Neuroscience.
[41] Francesco Marabita,et al. A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data , 2012, Bioinform..
[42] Linda Partridge,et al. Ageing as a Risk Factor for Disease , 2012, Current Biology.
[43] Alfonso Valencia,et al. Distinct DNA methylomes of newborns and centenarians , 2012, Proceedings of the National Academy of Sciences.
[44] Devin C. Koestler,et al. DNA methylation arrays as surrogate measures of cell mixture distribution , 2012, BMC Bioinformatics.
[45] F. Holsboer,et al. Dexamethasone Stimulated Gene Expression in Peripheral Blood is a Sensitive Marker for Glucocorticoid Receptor Resistance in Depressed Patients , 2012, Neuropsychopharmacology.
[46] Hyun-Jeong Ko,et al. Functional Changes in Myeloid-Derived Suppressor Cells (MDSCs) during Tumor Growth: FKBP51 Contributes to the Regulation of the Immunosuppressive Function of MDSCs , 2012, The Journal of Immunology.
[47] Bruce S. McEwen,et al. Adverse childhood experiences, allostasis, allostatic load, and age-related disease , 2012, Physiology & Behavior.
[48] Manolis Kellis,et al. ChromHMM: automating chromatin-state discovery and characterization , 2012, Nature Methods.
[49] C. Herder,et al. Association between social isolation and inflammatory markers in depressed and non-depressed individuals: Results from the MONICA/KORA study , 2011, Brain, Behavior, and Immunity.
[50] J. Potash,et al. A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice , 2011, Psychopharmacology.
[51] C. Pariante,et al. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor , 2011, Molecular Psychiatry.
[52] Krishna R. Kalari,et al. Integrated Analysis of Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells by Deep Sequencing , 2011, PloS one.
[53] Fabian J. Theis,et al. Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data , 2011, BMC Systems Biology.
[54] Xiao Zhang,et al. Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis , 2010, BMC Bioinformatics.
[55] V. Willour,et al. Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice. , 2010, Endocrinology.
[56] G. Wochnik,et al. Differential Impact of Tetratricopeptide Repeat Proteins on the Steroid Hormone Receptors , 2010, PloS one.
[57] J. Buchner,et al. The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules , 2010, The Journal of Neuroscience.
[58] A. Caspi,et al. Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. , 2009, Archives of pediatrics & adolescent medicine.
[59] B. Bradley,et al. Trauma exposure and stress-related disorders in inner city primary care patients. , 2009, General hospital psychiatry.
[60] S. Ghosh,et al. The NF-kappaB family of transcription factors and its regulation. , 2009, Cold Spring Harbor perspectives in biology.
[61] A. Hofman,et al. The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression , 2011, Neuron.
[62] F. Holsboer,et al. Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking , 2009, Genes, brain, and behavior.
[63] John D. Storey,et al. Eigen-R2 for dissecting variation in high-dimensional studies , 2008, Bioinform..
[64] Pan Du,et al. lumi: a pipeline for processing Illumina microarray , 2008, Bioinform..
[65] A. Caspi,et al. Elevated inflammation levels in depressed adults with a history of childhood maltreatment. , 2008, Archives of general psychiatry.
[66] K. Ressler,et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. , 2008, JAMA.
[67] Richie Poulton,et al. Childhood maltreatment predicts adult inflammation in a life-course study , 2007, Proceedings of the National Academy of Sciences.
[68] M. Gossen,et al. A protocol for combined Photinus and Renilla luciferase quantification compatible with protein assays. , 2006, Analytical biochemistry.
[69] F. Holsboer,et al. P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. , 2006, Human molecular genetics.
[70] M. Rehli,et al. Functional Analysis of Promoter CPG-Methylation using a CpG-Free Luciferase Reporter Vector , 2006, Epigenetics.
[71] J. Viikari,et al. Depressive symptoms and C-reactive protein: The Cardiovascular Risk in Young Finns Study , 2006, Psychological Medicine.
[72] J. Walter,et al. Down-regulation of Endogenous Amyloid Precursor Protein Processing due to Cellular Aging* , 2006, Journal of Biological Chemistry.
[73] Tarani Chandola,et al. Chronic stress at work and the metabolic syndrome: prospective study , 2006, BMJ : British Medical Journal.
[74] A. Döring,et al. C-reactive protein, depressed mood, and the prediction of coronary heart disease in initially healthy men: results from the MONICA-KORA Augsburg Cohort Study 1984-1998. , 2005, European heart journal.
[75] J. Eriksson,et al. Trajectories of growth among children who have coronary events as adults. , 2005, The New England journal of medicine.
[76] R Holle,et al. KORA - A Research Platform for Population Based Health Research , 2005, Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).
[77] Bing Zhang,et al. WebGestalt: an integrated system for exploring gene sets in various biological contexts , 2005, Nucleic Acids Res..
[78] Korbinian Strimmer,et al. An empirical Bayes approach to inferring large-scale gene association networks , 2005, Bioinform..
[79] F. Holsboer,et al. FK506-binding Proteins 51 and 52 Differentially Regulate Dynein Interaction and Nuclear Translocation of the Glucocorticoid Receptor in Mammalian Cells* , 2005, Journal of Biological Chemistry.
[80] S. Venuta,et al. Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells. , 2004, European journal of cancer.
[81] R. Peters,et al. IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women: The EPIC-Norfolk Prospective Population Study , 2004, Arteriosclerosis, thrombosis, and vascular biology.
[82] A. Döring,et al. Case-finding for depressive and exhausted mood in the general population: reliability and validity of a symptom-driven diagnostic scale. Results from the prospective MONICA/KORA Augsburg Study. , 2004, Annals of epidemiology.
[83] Giulio Superti-Furga,et al. A physical and functional map of the human TNF-α/NF-κB signal transduction pathway , 2004, Nature Cell Biology.
[84] J. Rumsfeld,et al. Depressive symptoms and health-related quality of life: the Heart and Soul Study. , 2003, JAMA.
[85] M. Kreek,et al. The Kreek-McHugh-Schluger-Kellogg scale: a new, rapid method for quantifying substance abuse and its possible applications. , 2003, Drug and alcohol dependence.
[86] M. Newcomb,et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. , 2003, Child abuse & neglect.
[87] C. Hsieh,et al. DNA Methylation Has a Local Effect on Transcription and Histone Acetylation , 2002, Molecular and Cellular Biology.
[88] Martin Vingron,et al. Variance stabilization applied to microarray data calibration and to the quantification of differential expression , 2002, ISMB.
[89] T. Grange,et al. Glucocorticoid‐induced DNA demethylation and gene memory during development , 2001, The EMBO journal.
[90] D. Williamson,et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. , 1998, American journal of preventive medicine.
[91] Zhaodan Cao,et al. NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176 , 1998 .
[92] M. Martin,et al. FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition , 1995, Molecular and cellular biology.
[93] K. Matsushima,et al. Essential involvement of interleukin‐8 (IL‐8) in acute inflammation , 1994, Journal of leukocyte biology.
[94] P. Richter,et al. PSYCHOMETRIC PROPERTIES OF THE BECK DEPRESSION INVENTORY , 1994 .
[95] A. Beck,et al. An inventory for measuring depression. , 1961, Archives of general psychiatry.
[96] E. Binder,et al. Gene–Stress–Epigenetic Regulation of FKBP5: Clinical and Translational Implications , 2016, Neuropsychopharmacology.
[97] A. Bracher,et al. Selective inhibitors of the FK506-binding protein 51 by induced fit. , 2015, Nature chemical biology.
[98] J. Stockman. Trajectories of Growth Among Children Who Have Coronary Events as Adults , 2007 .
[99] Cheng Li,et al. Adjusting batch effects in microarray expression data using empirical Bayes methods. , 2007, Biostatistics.
[100] G. Casari,et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. , 2004, Nature cell biology.
[101] D. Goeddel,et al. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[102] A. Beck,et al. Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation , 1988 .