Pathophysiology of Diarrhea and its Clinical Implications

[1]  E. Chang,et al.  Intestinal Water and Electrolyte Transport , 2012 .

[2]  N. Rezaei,et al.  Eponym: Johanson-Blizzard syndrome. , 2011 .

[3]  B. Zelger,et al.  Microvillous Inclusion Disease: A Clinicopathologic Study of 17 Cases from the UK , 2010, Ultrastructural pathology.

[4]  B. Dalgıç,et al.  Primary Intestinal Lymphangiectasia in Children: Is Octreotide an Effective and Safe Option in the Treatment? , 2010, Journal of pediatric gastroenterology and nutrition.

[5]  J. Rommens,et al.  Evidence of a Generalized Defect of Acinar Cell Function in Shwachman-Diamond Syndrome , 2010, Journal of pediatric gastroenterology and nutrition.

[6]  C. Mathers,et al.  Global, regional, and national causes of child mortality in 2008: a systematic analysis , 2010, The Lancet.

[7]  F. Powrie,et al.  Regulatory T cells reinforce intestinal homeostasis. , 2009, Immunity.

[8]  T. To,et al.  Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data , 2009, Gut.

[9]  J. Sellin,et al.  Review article: small intestinal bacterial overgrowth, bile acid malabsorption and gluten intolerance as possible causes of chronic watery diarrhoea , 2009, Alimentary pharmacology & therapeutics.

[10]  C. Wijmenga,et al.  Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. , 2009, American journal of human genetics.

[11]  Bart,et al.  Prospective human leukocyte antigen, endomysium immunoglobulin A antibodies, and transglutaminase antibodies testing for celiac disease in children with Down syndrome. , 2009, The Journal of pediatrics.

[12]  P. Dudeja,et al.  Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine. , 2008, Gastroenterology.

[13]  Julia Salleron,et al.  Natural history of pediatric Crohn's disease: a population-based cohort study. , 2008, Gastroenterology.

[14]  A. Opekun,et al.  Rising Incidence of Inflammatory Bowel Disease Among Children: A 12-year Study , 2010, Journal of pediatric gastroenterology and nutrition.

[15]  Judy H. Cho,et al.  Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease , 2008, Nature Genetics.

[16]  F. Chirdo,et al.  Celiac Disease Pathogenesis: The Proinflammatory Cytokine Network , 2008, Journal of pediatric gastroenterology and nutrition.

[17]  S. Nelson,et al.  Identification of EpCAM as the gene for congenital tufting enteropathy. , 2008, Gastroenterology.

[18]  Shobha S Rao,et al.  Gastrointestinal complications of diabetes. , 2008, American family physician.

[19]  M. Mearin,et al.  Review article: future research on coeliac disease – a position report from the European multistakeholder platform on coeliac disease (CDEUSSA) , 2008, Alimentary pharmacology & therapeutics.

[20]  A. Hofmann,et al.  Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics , 2008, Cellular and Molecular Life Sciences.

[21]  S. Zeissig,et al.  Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease. , 2008, Gastroenterology.

[22]  J. Walkowiak,et al.  The changing face of the exocrine pancreas in cystic fibrosis: pancreatic sufficiency, pancreatitis and genotype , 2008, European journal of gastroenterology & hepatology.

[23]  A. La Cava,et al.  Autoimmunity and celiac disease. , 2008, Mini reviews in medicinal chemistry.

[24]  C. Goldberg,et al.  Usefulness of heparin therapy in protein-losing enteropathy associated with single ventricle palliation. , 2008, The American journal of cardiology.

[25]  S. Srinivasan,et al.  Diabetes and the enteric nervous system , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[26]  C. Catassi,et al.  Coeliac disease epidemiology is alive and kicking, especially in the developing world. , 2007, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[27]  R. Xavier,et al.  Unravelling the pathogenesis of inflammatory bowel disease , 2007, Nature.

[28]  Simon C. Potter,et al.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.

[29]  A. Yüce,et al.  Duodenal appearance of giardiasis in a child with selective immunoglobulin A deficiency , 2007, Pediatrics international : official journal of the Japan Pediatric Society.

[30]  N. Brousse,et al.  Orphanet Journal of Rare Diseases BioMed Central Review Neonatal diabetes mellitus: a disease linked to multiple , 2007 .

[31]  W. Alrefai,et al.  Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications , 2007, Pharmaceutical Research.

[32]  G. Shull,et al.  PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[33]  Judy H. Cho,et al.  A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene , 2006, Science.

[34]  L. Melton,et al.  The epidemiology of microscopic colitis: a population based study in Olmsted County, Minnesota , 2006, Gut.

[35]  M. Leitges,et al.  Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. , 2006, The Journal of clinical investigation.

[36]  R. Troncone,et al.  Latest developments in the pathogenesis and treatment of celiac disease. , 2006, The Journal of pediatrics.

[37]  M. Zeitz,et al.  Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum , 2006, Gut.

[38]  D. Sack,et al.  Symptomatic hyponatremia during treatment of dehydrating diarrheal disease with reduced osmolarity oral rehydration solution. , 2006, JAMA.

[39]  M. Tsai,et al.  Mutant neurogenin-3 in congenital malabsorptive diarrhea. , 2006, The New England journal of medicine.

[40]  F. Ponti,et al.  Enteric neuroplasticity evoked by inflammation , 2006, Autonomic Neuroscience.

[41]  Alan D. Lopez,et al.  Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data , 2006, The Lancet.

[42]  M. Larocco,et al.  A Common Polymorphism in the Interleukin 8 Gene Promoter Is Associated with Clostridium difficile Diarrhea , 2006, The American Journal of Gastroenterology.

[43]  P. Höglund,et al.  Long-Term Clinical Outcome in Patients With Congenital Chloride Diarrhea , 2006, Journal of pediatric gastroenterology and nutrition.

[44]  S. Bischoff,et al.  Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives. , 2005, Gastroenterology.

[45]  P. Dawson,et al.  The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter* , 2005, Journal of Biological Chemistry.

[46]  F. Ghishan,et al.  Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8. , 2005, American journal of physiology. Gastrointestinal and liver physiology.

[47]  F. León,et al.  Clinical and Immunological Features of Adult-Onset Generalized Autoimmune Gut Disorder , 2004, American Journal of Gastroenterology.

[48]  S. Kritas,et al.  Small bowel bacterial overgrowth is a common cause of chronic diarrhea , 2004, Journal of gastroenterology and hepatology.

[49]  S. Holland,et al.  Gastrointestinal involvement in chronic granulomatous disease. , 2004, Pediatrics.

[50]  S. Al-Akash,et al.  Congenital sodium diarrhea in a neonate presenting as acute renal failure , 2004, Pediatric Nephrology.

[51]  M. Zeitz,et al.  Cytokine-dependent transcriptional down-regulation of epithelial sodium channel in ulcerative colitis. , 2004, Gastroenterology.

[52]  M. Zeitz,et al.  IL-1β and TNFα regulate sodium absorption in rat distal colon , 2004 .

[53]  N. C. Robinson,et al.  Identification of an N‐terminal amino acid of the CLC‐3 chloride channel critical in phosphorylation‐dependent activation of a CaMKII‐activated chloride current , 2004, The Journal of physiology.

[54]  Jianjing Xue,et al.  Mechanically evoked reflex electrogenic chloride secretion in rat distal colon is triggered by endogenous nucleotides acting at P2Y1, P2Y2, and P2Y4 receptors , 2004, The Journal of comparative neurology.

[55]  Jianjing Xue,et al.  Mechanical stimulation releases nucleotides that activate P2Y1 receptors to trigger neural reflex chloride secretion in guinea pig distal colon , 2004, The Journal of comparative neurology.

[56]  I. Korponay-Szabó,et al.  Elevation of IgG antibodies against tissue transglutaminase as a diagnostic tool for coeliac disease in selective IgA deficiency , 2003, Gut.

[57]  Raimundo B. Costa,et al.  Role of mast cells and pro-inflammatory mediators on the intestinal secretion induced by cholera toxin. , 2003, Toxicon : official journal of the International Society on Toxinology.

[58]  K. Schwarz,et al.  Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. , 2003, Pediatrics.

[59]  M. Ament,et al.  Induction of remission in a child with autoimmune enteropathy using mycophenolate mofetil. , 2003, Journal of pediatric gastroenterology and nutrition.

[60]  J. Boyer,et al.  Bile salt transporters: molecular characterization, function, and regulation. , 2003, Physiological reviews.

[61]  J. Gauldie,et al.  TGF-beta effects on epithelial ion transport and barrier: reduced Cl- secretion blocked by a p38 MAPK inhibitor. , 2002, American journal of physiology. Cell physiology.

[62]  G. Groisman,et al.  CD10: A Valuable Tool for the Light Microscopic Diagnosis of Microvillous Inclusion Disease (Familial Microvillous Atrophy) , 2002, The American journal of surgical pathology.

[63]  J. Gitschier,et al.  A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. , 2002, American journal of human genetics.

[64]  A. Fasano,et al.  Toxins and the gut: role in human disease , 2002, Gut.

[65]  J. Matthews.  Molecular Regulation of Na+-K+-2C1- Cotransporter (NKCC1) and Epithelial Chloride Secretion , 2002, World Journal of Surgery.

[66]  Ove Lundgren,et al.  Enteric nerves and diarrhoea. , 2002, Pharmacology & toxicology.

[67]  D. Pearce.  The role of SGK1 in hormone-regulated sodium transport , 2001, Trends in Endocrinology & Metabolism.

[68]  Mourad Sahbatou,et al.  Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease , 2001, Nature.

[69]  Judy H. Cho,et al.  A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease , 2001, Nature.

[70]  E. Chang,et al.  IFN-gamma downregulates expression of Na(+)/H(+) exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells. , 2001, American journal of physiology. Cell physiology.

[71]  E. Chang,et al.  Inhibition of Na+,K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier function. , 2001, Gastroenterology.

[72]  S. Sarker,et al.  Reduced osmolarity oral rehydration solution for persistent diarrhea in infants: a randomized controlled clinical trial. , 2001, The Journal of pediatrics.

[73]  B. Shneider.  Intestinal bile acid transport: biology, physiology, and pathophysiology. , 2001, Journal of pediatric gastroenterology and nutrition.

[74]  L B Reller,et al.  Practice guidelines for the management of infectious diarrhea. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[75]  R. Spiller,et al.  Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acuteCampylobacter enteritis and in post-dysenteric irritable bowel syndrome , 2000, Gut.

[76]  C. O'Morain,et al.  Increased mast cells in the irritable bowel syndrome , 2000, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[77]  H. Rossmann,et al.  Role of Na(+)HCO(3)(-) cotransporter NBC1, Na(+)/H(+) exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion. , 2000, Gastroenterology.

[78]  S. Ling,et al.  Microvillous inclusion disease: an evolving condition. , 2000, Journal of pediatric gastroenterology and nutrition.

[79]  J. Keith,et al.  Recombinant Human Interleukin-11 Modulates Ion Transport and Mucosal Inflammation in the Small Intestine and Colon , 2000, Laboratory Investigation.

[80]  J. Kere,et al.  Inherited disorders of ion transport in the intestine. , 2000, Current opinion in genetics & development.

[81]  G. Young,et al.  Amylase-resistant starch plus oral rehydration solution for cholera. , 2000, The New England journal of medicine.

[82]  G. Hecht,et al.  Myosin regulation of NKCC1: effects on cAMP-mediated Cl- secretion in intestinal epithelia. , 1999, American journal of physiology. Cell physiology.

[83]  C. Boey,et al.  Chronic diarrhoea in infants and young children: Causes, clinical features and outcome , 1999, Journal of paediatrics and child health.

[84]  R. Brown,et al.  Secretory villous adenomas that cause depletion syndrome. , 1999, Archives of internal medicine.

[85]  J. Hyams,et al.  Sacrosidase Therapy for Congenital Sucrase-Isomaltase Deficiency , 1998 .

[86]  J. Navarro,et al.  Intractable infant diarrhea with epithelial dysplasia associated with polymalformation. , 1998, Journal of pediatric gastroenterology and nutrition.

[87]  G. Sandle.  Salt and water absorption in the human colon: a modern appraisal , 1998, Gut.

[88]  C. Pothoulakis,et al.  Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins. , 1998, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[89]  W. Ryd,et al.  Hereditary Intractable Diarrhoea With Choanal Atresia - A New Familial Syndrome.: , 1997 .

[90]  J. Matthews,et al.  Na:K:2Cl Cotransporter (NKCC) of Intestinal Epithelial Cells , 1996, The Journal of Biological Chemistry.

[91]  A. Bousvaros,et al.  Treatment of pediatric autoimmune enteropathy with tacrolimus (FK506). , 1996, Gastroenterology.

[92]  E. Wright,et al.  Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption , 1996, Nature Genetics.

[93]  H. Cooke,et al.  Role for 5-HT and ACh in submucosal reflexes mediating colonic secretion. , 1995, The American journal of physiology.

[94]  Tadataka Yamada,et al.  Textbook of Gastroenterology , 1995 .

[95]  A. Casola,et al.  Etiology and Risk Factors of Severe and Protracted Diarrhea , 1995, Journal of pediatric gastroenterology and nutrition.

[96]  B. Kerem,et al.  Correlation between genotype and phenotype in patients with cystic fibrosis. , 1994, The New England journal of medicine.

[97]  F.J. Sauvage,et al.  Activation of intestinal CFTR Cl‐ channel by heat‐stable enterotoxin and guanylin via cAMP‐dependent protein kinase. , 1994, The EMBO journal.

[98]  P. Dagher,et al.  Effect of intracellular acidification on colonic NaCl absorption. , 1993, The American journal of physiology.

[99]  E. Chang,et al.  Epithelial Secretory Response to Inflammation , 1992, Annals of the New York Academy of Sciences.

[100]  H. Schulman,et al.  Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[101]  A. Phillips,et al.  Familial Microvillous Atrophy: A Clinicopathological Survey of 23 Cases , 1992, Journal of pediatric gastroenterology and nutrition.

[102]  R. Sibley,et al.  Microvillous Inclusion Disease: The Importance of Electron Microscopy for Diagnosis , 1991, The American journal of surgical pathology.

[103]  J. Spencer,et al.  Response to autoimmune enteropathy to cyclosporin A therapy. , 1991, Gut.

[104]  N. Brousse,et al.  Classification of intractable diarrhea in infancy using clinical and immunohistological criteria. , 1990, Gastroenterology.

[105]  R. Frizzell,et al.  Separate Cl- conductances activated by cAMP and Ca2+ in Cl(-)-secreting epithelial cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[106]  A. Zinsmeister,et al.  Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. , 1990, Gut.

[107]  L. Schiller,et al.  Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose. , 1989, The Journal of clinical investigation.

[108]  L. Weaver.  Bowel habit from birth to old age. , 1988, Journal of pediatric gastroenterology and nutrition.

[109]  L. Limbird.  Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[110]  M. Corey,et al.  Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreas. , 1988, Gastroenterology.

[111]  P. Milla,et al.  HLA product expression and lymphocyte subpopulations in jejunum biopsies of children with idiopathic protracted diarrhoea and enterocyte autoantibodies. , 1988, Journal of autoimmunity.

[112]  E. Chang,et al.  Calcium-mediated cyclic AMP inhibition of Na-H exchange in small intestine. , 1987, The American journal of physiology.

[113]  P. Milla,et al.  DEFECTIVE JEJUNAL BRUSH-BORDER Na+/H+ EXCHANGE: A CAUSE OF CONGENITAL SECRETORY DIARRHOEA , 1985, The Lancet.

[114]  J. Sellin,et al.  Rabbit proximal colon: a distinct transport epithelium. , 1984, The American journal of physiology.

[115]  P. Zentler-Munro,et al.  Effect of intrajejunal acidity on aqueous phase bile acid and lipid concentrations in pancreatic steatorrhoea due to cystic fibrosis. , 1984, Gut.

[116]  P. Milla,et al.  Disordered small intestinal motility: a rational basis for toddlers' diarrhoea. , 1983, Gut.

[117]  H. Greene,et al.  Excessive fluid intake as a cause of chronic diarrhea in young children. , 1983, The Journal of pediatrics.

[118]  G. Meeuwisse.  HIGH SUGAR WORSE THAN HIGH SODIUM IN ORAL REHYDRATION SOLUTIONS , 1983, Acta paediatrica Scandinavica.

[119]  P. Durie,et al.  Steatorrhea and pancreatic insufficiency in Shwachman syndrome. , 1982, Gastroenterology.

[120]  U. Hopfer,et al.  Induction of amiloride-sensitive sodium transport in the rat colon by mineralocorticoids , 1980 .

[121]  L. Turnberg,et al.  Electrolyte transport across colonic mucosa from patients with inflammatory bowel disease. , 1980, Gastroenterology.

[122]  K. Weismann,et al.  65Zinc absorption in patients suffering from acrodermatitis enteropathica and in normal adults assessed by whole‐body counting technique , 1979, The British journal of dermatology.

[123]  E. Cutz,et al.  Familial enteropathy: A syndrome of protracted diarrhea from birth, failure to thrive, and hypoplastic villus atrophy , 1978 .

[124]  A. Smith,et al.  Fecal characteristics contrasted in the irritable bowel syndrome and diverticular disease. , 1976, The American journal of clinical nutrition.

[125]  C. Matuchansky,et al.  Further studies on prostaglandin E1-induced jejunal secretion of water and electrolytes in man, with special reference to the influence of ethacrynic acid, furosemide, and aspirin. , 1976, Gastroenterology.

[126]  L. Feinendegen,et al.  ABSORPTION OF ZINC IN ACRODERMATITIS ENTEROPATHICA , 1975, The Lancet.

[127]  D. Habte,et al.  LACTOSE MALABSORPTION IN ETHIOPIAN CHILDREN , 1973, Acta paediatrica Scandinavica.

[128]  C. Clark,et al.  The absorption and secretion of water and electrolytes across the healthy and the diseased human colonic mucosa measured in vitro , 1972, Gut.

[129]  M. Field,et al.  Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins. , 1971, The Journal of clinical investigation.

[130]  D. Nalin,et al.  Rapid correction of acidosis and dehydration of cholera with oral electrolyte and glucose solution. , 1970, Lancet.

[131]  F. Rector,et al.  Mechanism of bicarbonate absorption and its relationship to sodium transport in the human jejunum. , 1970, The Journal of clinical investigation.

[132]  J. Fordtran,et al.  Interrelationships of chloride, bicarbonate, sodium, and hydrogen transport in the human ileum. , 1970, The Journal of clinical investigation.

[133]  T. Bayless,et al.  A racial difference in incidence of lactase deficiency. A survey of milk intolerance and lactase deficiency in healthy adult males. , 1966, JAMA.

[134]  J. Fordtran,et al.  Ionic constituents and osmolality of gastric and small-intestinal fluids after eating , 1966, The American Journal of Digestive Diseases.

[135]  J. Kamer,et al.  Diarrhoea Caused by Deficiency of Sugar Splitting Enzymes. I , 1960, Acta paediatrica.

[136]  R. Fisher.  The absorption of water and of some small solute molecules from the isolated small intestine of the rat , 1955, The Journal of physiology.

[137]  F. Monpoux,et al.  Le syndrome de Pearson : à propos de 2 observations à révélation néonatale , 2010 .

[138]  H. Binder.  INTESTINAL FLUID AND ELECTROLYTE MOVEMENT , 2009 .

[139]  P. Höglund,et al.  Oral butyrate in treatment of congenital chloride diarrhea. , 2008, The American journal of gastroenterology.

[140]  P. Ngo,et al.  The pathobiology of eosinophilic gastroenteritis of childhood: Is it really the eosinophil, allergic mediated, or something else? , 2004, Current gastroenterology reports.

[141]  S. Orenstein,et al.  Eosinophilic Gastroenteritis , 2002, Paediatric drugs.

[142]  K. Kunzelmann,et al.  Electrolyte transport in the mammalian colon: mechanisms and implications for disease. , 2002, Physiological reviews.

[143]  R. Greger,et al.  Role of CFTR in the colon. , 2000, Annual review of physiology.

[144]  F. Hofmann,et al.  Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colon. , 2000, Gastroenterology.

[145]  S. Sheen-Chen,et al.  Eosinophilic gastroenteritis: 10 years experience. , 1993, The American journal of gastroenterology.

[146]  C. Boeck.  Correlation between genotype and phenotype in patients with cystic fibrosis , 1993 .

[147]  E. Wright,et al.  Expression cloning and cDNA sequencing of the Na+/glucose co-transporter , 1987, Nature.

[148]  Evans Gw.  Zinc and its deficiency diseases. , 1986 .

[149]  A. Jonas,et al.  Stool output and composition in the chronic non-specific diarrhoea syndrome. , 1982, Archives of disease in childhood.

[150]  J. Russell.  Letter: The ten-day rule. , 1976, Lancet.

[151]  J. Pershad,et al.  Lactase deficiency in Indians. , 1972, The American journal of clinical nutrition.