A systematic review and meta‐analysis of prescribing practices of antidepressants in cancer patients

Antidepressants are commonly used for the pharmacological treatment of depression. We aimed to summarise the prevalence of antidepressant prescription to cancer patients, and differences by study or patient characteristics.

[1]  M. Delgado-Rodríguez,et al.  Systematic review and meta-analysis. , 2017, Medicina intensiva.

[2]  Nobhojit Roy,et al.  The Global Burden of Cancer 2013. , 2015, JAMA oncology.

[3]  M. Abrahamowicz,et al.  Antidepressant therapy in cancer patients: initiation and factors associated with treatment , 2015, Pharmacoepidemiology and drug safety.

[4]  J. Manola,et al.  Patterns and predictors of antidepressant use in ambulatory cancer patients with common solid tumors , 2015, Psycho-oncology.

[5]  T. Si,et al.  Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia: The Research on East Asian Psychotropic Prescription Patterns Study , 2015, Chinese medical journal.

[6]  F. Cousson-Gélie,et al.  Oncologists’ perception of depressive symptoms in patients with advanced cancer: accuracy and relational correlates , 2015, BMC psychology.

[7]  Evette Ludman,et al.  Medical comorbidity and psychotropic medication fills in older adults with breast or prostate cancer , 2015, Supportive Care in Cancer.

[8]  L. Lechner,et al.  Profiling physical activity motivation based on self-determination theory: a cluster analysis approach , 2015, BMC psychology.

[9]  H. Wittchen,et al.  Four-week prevalence of mental disorders in patients with cancer across major tumor entities. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[10]  M. Hjermstad,et al.  The use of antidepressants in patients with advanced cancer—results from an international multicentre study , 2014, Psycho-oncology.

[11]  Janeane L. Walker,et al.  Prevalence, associations, and adequacy of treatment of major depression in patients with cancer: a cross-sectional analysis of routinely collected clinical data. , 2014, The lancet. Psychiatry.

[12]  Libo Zhao,et al.  Prevalence, correlates and recognition of depression in Chinese inpatients with cancer. , 2014, General hospital psychiatry.

[13]  S. Martins,et al.  Prevalence of depression morbidity among Brazilian adults: a systematic review and meta-analysis. , 2014, Revista brasileira de psiquiatria.

[14]  R. Kessler,et al.  Comorbidity of common mental disorders with cancer and their treatment gap: findings from the World Mental Health Surveys , 2014, Psycho-oncology.

[15]  J. Reeve,et al.  Antidepressant medication in patients with advanced cancer--an observational study. , 2013, QJM : monthly journal of the Association of Physicians.

[16]  C. Yen,et al.  Management of Depression in Taiwan: Unmet Needs in Advanced Pancreatic Cancer Patients? , 2013 .

[17]  Tzeng-Ji Chen,et al.  Incidence and risk of mood disorders in patients with breast cancers in Taiwan: a nationwide population‐based study , 2013, Psycho-oncology.

[18]  D. Malone,et al.  A practical approach to prescribing antidepressants , 2013, Cleveland Clinic Journal of Medicine.

[19]  L. Wissen,et al.  Developing a model for type 2 diabetes mellitus medication use prevalence at local level , 2013 .

[20]  J. Spinelli,et al.  Antidepressant use among survivors of childhood, adolescent and young adult cancer: A report of the childhood, adolescent and young adult cancer survivor (CAYACS) research program , 2013, Pediatric blood & cancer.

[21]  I. Hickie,et al.  Young men’s attitudes and behaviour in relation to mental health and technology: implications for the development of online mental health services , 2013, BMC Psychiatry.

[22]  M. Boks,et al.  Prescription patterns for psychotropic drugs in cancer patients; a large population study in the Netherlands , 2013, Psycho-oncology.

[23]  Janeane L. Walker,et al.  Prevalence of depression in adults with cancer: a systematic review. , 2013, Annals of oncology : official journal of the European Society for Medical Oncology.

[24]  M. Hjermstad,et al.  Antidepressants to cancer patients during the last year of life—a population‐based study , 2013, Psycho-oncology.

[25]  N. Zhang,et al.  Psychoactive medication use and neurocognitive function in adult survivors of childhood cancer: A report from the childhood cancer survivor study , 2013, Pediatric blood & cancer.

[26]  J. López-Torres,et al.  Follow up of patients who start treatment with antidepressants: treatment satisfaction, treatment compliance, efficacy and safety , 2013, BMC Psychiatry.

[27]  I. McGregor,et al.  Trends in the utilisation of psychotropic medications in Australia from 2000 to 2011 , 2013, The Australian and New Zealand journal of psychiatry.

[28]  John R. Moran,et al.  Use of psychotropic medications by US cancer survivors , 2012, Psycho-oncology.

[29]  K. Lefevre,et al.  Incidence and drug treatment of emotional distress after cancer diagnosis: a matched primary care case–control study , 2012, British Journal of Cancer.

[30]  U. Sambamoorthi,et al.  Depression Treatment Patterns among Elderly with Cancer , 2012, Depression research and treatment.

[31]  G. A. Miller,et al.  Neuromagnetic Indication of Dysfunctional Emotion Regulation in Affective Disorders , 2012, Depression research and treatment.

[32]  S. Mojal,et al.  Changes in the prescription of psychotropic drugs in the palliative care of advanced cancer patients over a seven-year period. , 2012, Journal of pain and symptom management.

[33]  Kimito Yamada,et al.  [Assessment of psychological distress in cancer outpatients treated with chemotherapy]. , 2012, Gan to kagaku ryoho. Cancer & chemotherapy.

[34]  E. Mohammadi,et al.  Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[35]  Q. Gu,et al.  Antidepressant use in persons aged 12 and over: United States, 2005-2008. , 2011, NCHS data brief.

[36]  L. de Jong-van den Berg,et al.  Psychotropic medication during endocrine treatment for breast cancer , 2011, Supportive Care in Cancer.

[37]  F. Drago,et al.  Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract. , 2011, Current drug metabolism.

[38]  H. Möller,et al.  Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care , 2011, World psychiatry : official journal of the World Psychiatric Association.

[39]  N. Meader,et al.  Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. , 2011, The Lancet. Oncology.

[40]  C. Johansen,et al.  Factors associated with the prescription of antidepressive medication to breast cancer patients , 2011, Acta oncologica.

[41]  A. Ward,et al.  Consulting and prescribing behaviour for anxiety and depression in long-term survivors of cancer in the UK. , 2010, European journal of cancer.

[42]  T. Gomes,et al.  Patterns of antidepressant use among women initiating tamoxifen therapy for the treatment of breast cancer in Ontario, Canada. , 2010 .

[43]  B. Zhong,et al.  Prevalence, correlates and recognition of depression among inpatients of general hospitals in Wuhan, China. , 2010, General hospital psychiatry.

[44]  Stefan Schneider,et al.  Depression as a predictor of disease progression and mortality in cancer patients , 2010, Cancer.

[45]  Tom Jefferson,et al.  Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis , 2009, BMJ : British Medical Journal.

[46]  W. Linden,et al.  Depression as a predictor of disease progression and mortality in cancer patients , 2009, Cancer.

[47]  T. Kendrick,et al.  Explaining the rise in antidepressant prescribing: a descriptive study using the general practice research database , 2009, BMJ : British Medical Journal.

[48]  D. Kissane Beyond the psychotherapy and survival debate: the challenge of social disparity, depression and treatment adherence in psychosocial cancer care , 2009, Psycho-oncology.

[49]  M. Biondi,et al.  Depression in cancer patients: a critical review , 2007, Clinical practice and epidemiology in mental health : CP & EMH.

[50]  T. Steinert,et al.  Clinical Practice and Epidemiology in Mental Health the Use of Mechanical Restraint and Seclusion in Patients with Schizophrenia: a Comparison of the Practice in Germany and Switzerland , 2006 .

[51]  H. Chochinov,et al.  Depression and anxiety disorders in palliative cancer care. , 2007, Journal of pain and symptom management.

[52]  Xiaomei Ma,et al.  Global Burden of Cancer , 2006, The Yale journal of biology and medicine.

[53]  A. Onitilo,et al.  Effect of depression on all-cause mortality in adults with cancer and differential effects by cancer site. , 2006, General hospital psychiatry.

[54]  D. Greenberg Barriers to the treatment of depression in cancer patients. , 2004, Journal of the National Cancer Institute. Monographs.

[55]  P. Ellis,et al.  Australian and New Zealand Clinical Practice Guidelines for the Treatment of Depression , 2004 .

[56]  J. Coyne,et al.  Distress, psychiatric morbidity, and prescriptions for psychotropic medication in a breast cancer waiting room sample. , 2004, General hospital psychiatry.

[57]  Helgi Tómasson,et al.  Antidepressants and public health in Iceland , 2004, British Journal of Psychiatry.

[58]  A. House,et al.  Major depression in outpatients attending a regional cancer centre: screening and unmet treatment needs , 2004, British Journal of Cancer.

[59]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[60]  P. Raich,et al.  Antidepressant prescribing in community cancer care , 2003, Supportive Care in Cancer.

[61]  I. Hickie,et al.  Summary of Guideline for the Treatment of Depression , 2003 .

[62]  M. Hotopf,et al.  Depression in advanced disease: a systematic review Part 1. Prevalence and case finding , 2002, Palliative medicine.

[63]  M. Hotopf,et al.  Depression in advanced disease: a systematic review - Part 1. Prevalence and case finding , 2002 .

[64]  W. Breitbart,et al.  Depression, hopelessness, and desire for hastened death in terminally ill patients with cancer. , 2000, JAMA.

[65]  M. Lloyd-Williams,et al.  A survey of antidepressant prescribing in the terminally ill , 1999, Palliative medicine.

[66]  N. Walsh,et al.  The use of psychotropic medication in patients referred to a psycho‐oncology service , 1998, Psycho-oncology.

[67]  G. Smith,et al.  Bias in meta-analysis detected by a simple, graphical test , 1997, BMJ.

[68]  S. Valente,et al.  Diagnosis and treatment of major depression among people with cancer. , 1997, Cancer nursing.

[69]  G. Hortobagyi,et al.  Use of tamoxifen for breast cancer: twenty-eight years later. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[70]  P. Maguire,et al.  Antidepressant medications in cancer patients , 1994 .

[71]  E. Perez-stable,et al.  Depression in medical outpatients. Underrecognition and misdiagnosis. , 1990, Archives of internal medicine.

[72]  J. Holland,et al.  Changes in the prescription patterns of psychotropic drugs for cancer patients during a 10‐year period , 1990, Cancer.

[73]  G. Morrow,et al.  A survey of psychotropic drug utilization by patients with advanced neoplastic disease. , 1985, General hospital psychiatry.

[74]  V. Mor,et al.  A survey of psychotropic use in terminal cancer patients. , 1985, Psychosomatics.

[75]  J. Holland,et al.  A survey of psychotropic drug prescriptions in an oncology population , 1979, Cancer.

[76]  Sowmya R. Rao,et al.  Patterns of psychiatric medication use among nationally representative long‐term cancer survivors and controls , 2015, Cancer.

[77]  N. Zainal,et al.  Comparison of psychotropic prescriptions between oncology and cardiology inpatients: result from a pharmacy database in a teaching hospital in Malaysia. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[78]  P. Gøtzsche Our prescription drugs kill us in large numbers. , 2014, Polskie Archiwum Medycyny Wewnetrznej.

[79]  C. Printz,et al.  Care, compounded: Researchers delve into reasons behind pregnancy‐associated breast cancer , 2014, Cancer.

[80]  N. D. de Wit,et al.  Psychiatric comorbidity among terminally ill patients in general practice in the Netherlands: a comparison between patients with cancer and heart failure. , 2013, The British journal of general practice : the journal of the Royal College of General Practitioners.

[81]  N. Keating,et al.  Trends in co-prescribing of antidepressants and tamoxifen among women with breast cancer, 2004–2010 , 2012, Breast Cancer Research and Treatment.

[82]  M. Die Trill Psychological aspects of depression in cancer patients: an update. , 2012, Annals of oncology : official journal of the European Society for Medical Oncology.

[83]  Christine Y. Lu,et al.  New users of antidepressant medications: first episode duration and predictors of discontinuation , 2011, European Journal of Clinical Pharmacology.

[84]  C. Sternberg,et al.  Detection and treatment of depressive and anxiety disorders among cancer patients: feasibility and preliminary findings from a liaison service in an oncology division , 2006, Depression and anxiety.

[85]  J. Hinrichs,et al.  The influence of cytochrome P450 pharmacogenetics on disposition of common antidepressant and antipsychotic medications. , 2006, The Clinical biochemist. Reviews.