The Bivalent Cu, Ni and Zn Complexes of Unsymmetrical ONO Tridentate Schiff Base Ligands Derived from 2-Aminobenzoic Acid: Antimicrobial and Molluscicidal Activity

Bivalent Cu(II), Ni(II) and Zn(II) complexes were synthesized using the prepared tridentate Schiff base ligands derived from 2-aminobenzoic acid as the primary amine condensed with different substituted aldehydes (salicylic acid, 0-vaniline, 2-carboxybenzaldehyde, 1-(3formyl-4-hydroxyphenylazo)-4-methylbenzene and 1-(3formyl-4-hydroxyphenylazo benzene). The ligands and their corresponding complexes have been characterized using analytical, spectroscopic, conductivity and magnetic moment measurements. The analytical data showed the stoichiometry of the metals to ligands was (1:1). The conductivity data showed that all the complexes were non-electrolytes. The geometry of Cu(II) complexes were suggested to be distorted square planer. Ni(II) complexes are square-planar and Zn(II) complexes were tetrahedral. The antimicrobial investigation showed that the metal complexes had remarkable enhancement of activity with zinc complexes and were having highest susceptibility. The complex [ZnSL4.H2O] showed MIC value of 12.5 μg/ disc against Candida albicans and the complex [ZnSL5.H2O] indicated MIC value of 50 μg/disc against Streptococcus pneumonia. The molluscicidal activity tests against the land snail Eobania vermiculata showed that complexes were more toxic with LC 50 of 0.4 mg/L, while the LC 50 of the ligands was at 0.5 mg/L.

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