Parafallopian tube transitional cell carcinoma.

BACKGROUND Transitional cell carcinoma (TCC) has recently been acknowledged as a distinct histologic pattern of the uncommon primary fallopian tube carcinoma. However, rare cases of TCC that are closely associated to the extraluminal portion of the tube remain widely unrecognized. CASE We present a left adnexal high-grade TCC in a 56-year-old postmenopausal woman with an elevated serum CA-125 level. The tumor was attached by a small stalk to the serosal surface of the left fallopian tube and was completely separate from the uninvolved uterus and ipsilateral ovary. Histologic examination of the tubal lumen epithelium revealed neither atypia nor involvement by the neoplasm. Immunohistochemistry showed the tumor cells to be positive for pankeratin, calretinin, progesterone and estrogen receptors, and cytokeratin 7, and negative for cytokeratin 20, consistent with a Mullerian derivation. CONCLUSION Our case represents the fourth reported instance of a primary paratubal TCC. Perhaps, this entity falls under a previously unrecognized category of carcinomas that collectively may arise from Walthard's rest, paratubal cyst, or directly from the tubal serosa.

[1]  R. Scully,et al.  Carcinoma of the fallopian tube: a clinicopathological study of 105 cases with observations on staging and prognostic factors. , 1999, Gynecologic oncology.

[2]  R. Ashfaq,et al.  Transitional cell carcinoma of the endometrium and endometrial carcinoma with transitional cell differentiation , 1997, Cancer.

[3]  T. Ulbright,et al.  Transitional cell carcinoma and other transitional cell tumors of the ovary. , 1996, Anatomic pathology.

[4]  H. Dave,et al.  Transitional cell carcinoma arising within a paratubal cyst: report of a case. , 1995, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[5]  I. Konishi,et al.  Transitional cell carcinoma of the fallopian tube: a light and electron microscopic study. , 1994, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[6]  M. Tsuneyoshi,et al.  Transitional cell carcinoma pattern in primary carcinoma of the fallopian tube , 1993, Cancer.

[7]  G. Meeks,et al.  EXTRAOVARIAN BRENNER TUMOR , 1992, Obstetrics and gynecology.

[8]  D. Gershenson,et al.  Ovarian carcinomas with transitional cell carcinoma pattern. , 1990, American journal of clinical pathology.

[9]  M. Ed Tumors of the peritoneum , 1973 .

[10]  Q. Federman,et al.  Primary transitional cell tumor of the uterine adnexa. , 1973, American journal of obstetrics and gynecology.

[11]  Fennell Rh,et al.  Primary carcinoma of the fallopian tube. , 1956 .

[12]  T. B. Teoh The structure and development of Walthard nests. , 1953, The Journal of pathology and bacteriology.

[13]  A. Hertig,et al.  Primary carcinoma of the fallopian tube. , 1950, American journal of obstetrics and gynecology.