Cadherin exits the junction by switching its adhesive bond

Intercellular traction forces or lateral alignment of cadherin molecules can influence adherens junction dynamics by altering the cadherin dimerization interface.

[1]  O. Pertz,et al.  A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E‐cadherin homoassociation , 1999, The EMBO journal.

[2]  N. Inoue,et al.  Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formation. , 2006, Experimental cell research.

[3]  A. Kiss,et al.  p120-catenin is a key component of the cadherin-gamma-secretase supercomplex. , 2008, Molecular biology of the cell.

[4]  Elaine Fuchs,et al.  Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion , 2000, Cell.

[5]  Peter D. Kwong,et al.  Structural basis of cell-cell adhesion by cadherins , 1995, Nature.

[6]  Cynthia L. Adams,et al.  Mechanisms of Epithelial Cell–Cell Adhesion and Cell Compaction Revealed by High-resolution Tracking of E-Cadherin– Green Fluorescent Protein , 1998, The Journal of cell biology.

[7]  B. Honig,et al.  Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins. , 2008, Structure.

[8]  S. Yonemura,et al.  α-Catenin as a tension transducer that induces adherens junction development , 2010, Nature Cell Biology.

[9]  J. Klingelhöfer,et al.  Dynamic Interplay between Adhesive and Lateral E-Cadherin Dimers , 2002, Molecular and Cellular Biology.

[10]  S. Grzesiek,et al.  Proteolytic E‐cadherin activation followed by solution NMR and X‐ray crystallography , 2004, The EMBO journal.

[11]  I. Gelfand,et al.  Dynamics of contacts between lamellae of fibroblasts: essential role of the actin cytoskeleton. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[12]  E. Sokolov,et al.  Adhesive and Lateral E-Cadherin Dimers Are Mediated by the Same Interface , 2003, Molecular and Cellular Biology.

[13]  T. Boggon,et al.  C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms , 2002, Science.

[14]  J. Klingelhöfer,et al.  Both the dimerization and immunochemical properties of E-cadherin EC1 domain depend on Trp(156) residue. , 2002, Archives of biochemistry and biophysics.

[15]  J. Engel,et al.  Modulation of E-cadherin monomer folding by cooperative binding of calcium ions. , 2008, Biochemistry.

[16]  D. Leckband Beyond structure: mechanism and dynamics of intercellular adhesion. , 2008, Biochemical Society transactions.

[17]  P. Hersen,et al.  Strength dependence of cadherin-mediated adhesions. , 2010, Biophysical journal.

[18]  S. Troyanovsky,et al.  Adhesive But Not Lateral E-cadherin Complexes Require Calcium and Catenins for Their Formation , 1998, The Journal of cell biology.

[19]  B. Gumbiner,et al.  Regulation of cadherin-mediated adhesion in morphogenesis , 2005, Nature Reviews Molecular Cell Biology.

[20]  Wayne A. Hendrickson,et al.  Structure-Function Analysis of Cell Adhesion by Neural (N-) Cadherin , 1998, Neuron.

[21]  B. Honig,et al.  Two-step adhesive binding by classical cadherins , 2010, Nature Structural &Molecular Biology.

[22]  M. Ikura,et al.  Structural basis of calcium-induced E-cadherin rigidification and dimerization , 1996, Nature.

[23]  Steven Chu,et al.  Characterizing the initial encounter complex in cadherin adhesion. , 2009, Structure.

[24]  W. Nelson,et al.  Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell–cell adhesion , 2007, The Journal of cell biology.

[25]  A. Ivanov,et al.  Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. , 2005, Molecular biology of the cell.

[26]  O. Harrison,et al.  Cadherin adhesion depends on a salt bridge at the N-terminus , 2005, Journal of Cell Science.

[27]  M. Takeichi,et al.  Remodeling of the adherens junctions during morphogenesis. , 2009, Current topics in developmental biology.

[28]  S. Chu,et al.  Resolving cadherin interactions and binding cooperativity at the single-molecule level , 2009, Proceedings of the National Academy of Sciences.

[29]  C. Kay,et al.  Multiple cadherin extracellular repeats mediate homophilic binding and adhesion , 2001, The Journal of cell biology.

[30]  M. Takeichi,et al.  Basal-to-apical cadherin flow at cell junctions , 2007, Nature Cell Biology.

[31]  Samantha J. Stehbens,et al.  Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts. , 2005, Molecular biology of the cell.

[32]  F. Amblard,et al.  Endocytosis is required for E-cadherin redistribution at mature adherens junctions , 2009, Proceedings of the National Academy of Sciences.

[33]  A. Nose,et al.  N-linked oligosaccharides are not involved in the function of a cell-cell binding glycoprotein E-cadherin. , 1986, Cell structure and function.

[34]  E. Sokolov,et al.  Endocytosis of cadherin from intracellular junctions is the driving force for cadherin adhesive dimer disassembly. , 2006, Molecular biology of the cell.

[35]  Fabiana Bahna,et al.  Cadherin-mediated cell-cell adhesion: sticking together as a family. , 2003, Current opinion in structural biology.

[36]  Soonjin Hong,et al.  Spontaneous assembly and active disassembly balance adherens junction homeostasis , 2010, Proceedings of the National Academy of Sciences.

[37]  W. Nelson,et al.  Regulation of cell-cell adhesion by the cadherin-catenin complex. , 2008, Biochemical Society transactions.

[38]  Benjamin Geiger,et al.  Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize. , 2006, Current opinion in cell biology.

[39]  S. Troyanovsky,et al.  Stable and unstable cadherin dimers: mechanisms of formation and roles in cell adhesion. , 2007, Molecular biology of the cell.

[40]  B. Honig,et al.  The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. , 2011, Structure.

[41]  D. Rimm,et al.  Controversies at the cytoplasmic face of the cadherin-based adhesion complex. , 1999, Current opinion in cell biology.

[42]  B. Honig,et al.  Cooperativity between trans and cis interactions in cadherin-mediated junction formation , 2010, Proceedings of the National Academy of Sciences.

[43]  S. Troyanovsky Cadherin dimers in cell-cell adhesion. , 2005, European journal of cell biology.

[44]  A. Lustig,et al.  Calcium binding and homoassociation of E-cadherin domains. , 1997, Biochemistry.