Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
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David J. Gagne | Brian P. Frushour | Peter J. Elliott | Jesse J. Smith | Renée Kenney | William Ladd | Heidi L. Galonek | Kristine Israelian | Jeffrey Song | Giedre Razvadauskaite | Amy V. Lynch | David P. Carney | Robin J. Johnson | Siva Lavu | Andre Iffland | Philip D. Lambert | Keith O. Elliston | Michael R. Jirousek | Jill C. Milne | Olivier Boss | D. Gagne | P. Elliott | Siva Lavu | P. Lambert | O. Boss | Brian P. Frushour | J. Milne | Jeffrey Song | M. Jirousek | W. Ladd | A. Iffland | Jesse J. Smith | H. Galonek | Kristine Israelian | Keith Owen Elliston | Renée Kenney | Giedre Razvadauskaite
[1] Namjin Chung,et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ , 2004, Nature.
[2] L. Partridge,et al. Dietary restriction in Drosophila , 2005, Mechanisms of Ageing and Development.
[3] M. Mayo,et al. Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase , 2004, The EMBO journal.
[4] H. Chung,et al. The Inflammation Hypothesis of Aging , 2001 .
[5] J. Halter,et al. Caloric restriction mimetics: metabolic interventions. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.
[6] V. Giguère,et al. Estrogen-Related Receptor α Directs Peroxisome Proliferator-Activated Receptor α Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle , 2004, Molecular and Cellular Biology.
[7] G. Bray,et al. Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. , 2005, The Journal of clinical investigation.
[8] D. L. Le Couteur,et al. Life Extension by Calorie Restriction in Humans , 2007, Annals of the New York Academy of Sciences.
[9] J. Plutzky,et al. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. , 2007, Circulation.
[10] Jack Coulehan,et al. Family History , 2014, Annals of Internal Medicine.
[11] G. Ferns,et al. The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis. , 2006, Atherosclerosis.
[12] J. Cidlowski,et al. Mechanisms of glucocorticoid receptor signaling during inflammation , 2004, Mechanisms of Ageing and Development.
[13] J. Auwerx,et al. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. , 2008, Cell metabolism.
[14] P. Puigserver,et al. Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.
[15] J. Davis. Bioinformatics and Computational Biology Solutions Using R and Bioconductor , 2007 .
[16] M. Christian,et al. Metabolic regulation by the nuclear receptor corepressor RIP140 , 2006, Trends in Endocrinology & Metabolism.
[17] P. Puigserver,et al. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.
[18] G. Bray,et al. Family History of Diabetes Links Impaired Substrate Switching and Reduced Mitochondrial Content in Skeletal Muscle , 2007, Diabetes.
[19] A. Bartke,et al. PPARs in Calorie Restricted and Genetically Long-Lived Mice , 2006, PPAR research.
[20] P. Robbins,et al. Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. , 2007, The Biochemical journal.
[21] Steven P Gygi,et al. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. , 2005, Nature.
[22] Emilio Clementi,et al. Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS , 2005, Science.
[23] S. Kersten,et al. PPARs, Obesity, and Inflammation , 2006, PPAR research.
[24] E. Ravussin,et al. Calorie restriction and aging: review of the literature and implications for studies in humans. , 2003, The American journal of clinical nutrition.
[25] S. Nemoto,et al. SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α* , 2005, Journal of Biological Chemistry.
[26] N. Elmalı,et al. Effects of Resveratrol in Inflammatory Arthritis , 2007, Inflammation.
[27] David Sinclair,et al. Sirtuins in mammals: insights into their biological function. , 2007, The Biochemical journal.
[28] P. Barnes,et al. Treatment of airway mucus hypersecretion , 2006, Annals of medicine.
[29] L. N. Valenti,et al. Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes* , 2005, Journal of Biological Chemistry.
[30] L. Guarente,et al. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. , 2007, Molecular cell.
[31] Eric Verdin,et al. Conserved metabolic regulatory functions of sirtuins. , 2008, Cell metabolism.
[32] Amy V. Lynch,et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes , 2007, Nature.
[33] M. McVey,et al. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. , 1999, Genes & development.
[34] B. Chandrasekar,et al. Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted diet. , 2006, Biochemical and biophysical research communications.
[35] J. Auwerx,et al. Sirtuins: The ‘magnificent seven’, function, metabolism and longevity , 2007, Annals of medicine.
[36] N. Holden,et al. Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor? , 2007, Molecular Pharmacology.
[37] S. Minucci,et al. Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence , 2002, The EMBO journal.
[38] Thomas Mammone,et al. SIRT1 promotes differentiation of normal human keratinocytes. , 2009, The Journal of investigative dermatology.
[39] N. Hacohen,et al. Tumor necrosis factor-α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: Nuclear factor-κB activation by TNF-α is obligatory , 2002 .
[40] U. Jeschke,et al. Peroxisome Proliferator‐Activated Receptors: New Players in the Field of Reproduction , 2007, American journal of reproductive immunology.
[41] Cuk-Seong Kim,et al. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase , 2007, Proceedings of the National Academy of Sciences.
[42] G. Williams. Antitumor necrosis factor-alpha therapy and potential cancer inhibition. , 2008, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.
[43] S. Nicosia,et al. Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation , 2005, The EMBO journal.
[44] P. Puigserver,et al. Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-α , 2005, International Journal of Obesity.
[45] E. Ravussin,et al. Energy restriction and aging , 2004, Current opinion in clinical nutrition and metabolic care.
[46] P. Elliott,et al. SIRT1 activation confers neuroprotection in experimental optic neuritis. , 2007, Investigative ophthalmology & visual science.
[47] E. Oakeley,et al. The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[48] A. Poulsen,et al. SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents , 2006, Journal of biomolecular screening.
[49] L. Guarente,et al. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans , 2001, Nature.
[50] K. Tronstad,et al. The metabolic syndrome and the hepatic fatty acid drainage hypothesis. , 2005, Biochimie.
[51] M. Mattson,et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. , 2007, Free radical biology & medicine.
[52] J. Auwerx,et al. Transcriptional coregulators in the control of energy homeostasis. , 2007, Trends in cell biology.
[53] Steven P. Gygi,et al. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase , 2004, Science.
[54] B. Spiegelman,et al. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. , 2006, Endocrine reviews.
[55] N. Hacohen,et al. Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. , 2002, Diabetes.
[56] T. Shioi,et al. Resveratrol ameliorates experimental autoimmune myocarditis. , 2007, Circulation journal : official journal of the Japanese Circulation Society.
[57] B. Rogina,et al. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[58] Min Zhu,et al. Calorie restriction mimetics: an emerging research field , 2006, Aging cell.
[59] J. Wood,et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans , 2004, Nature.
[60] R. Medema,et al. FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the Longevity Protein hSir2SIRT1* , 2004, Journal of Biological Chemistry.
[61] O. Boss,et al. Targeting PGC-1α to control energy homeostasis , 2007, Expert opinion on therapeutic targets.
[62] D. G. Newman,et al. Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status. , 2003, The Journal of clinical endocrinology and metabolism.
[63] R. Weinberg,et al. hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase , 2001, Cell.
[64] D. Ingram,et al. Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging , 2007, Neuroscience.
[65] Rafael A Irizarry,et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.
[66] W. Yong,et al. Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes. , 2008, Biochemical and biophysical research communications.
[67] A. Elsharkawy,et al. Nuclear factor‐κB and the hepatic inflammation‐fibrosis‐cancer axis , 2007 .
[68] Jean YH Yang,et al. Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.
[69] I. Rahman,et al. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. , 2007, American journal of physiology. Lung cellular and molecular physiology.
[70] C. Ballantyne,et al. Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction. , 2004, The Journal of clinical endocrinology and metabolism.
[71] Eric Ravussin,et al. Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans , 2007, PLoS medicine.
[72] C. Burant,et al. Role of FoxO1 in FFA-induced oxidative stress in adipocytes. , 2007, American journal of physiology. Endocrinology and metabolism.
[73] J. Holloszy,et al. Caloric restriction in humans , 2007, Experimental Gerontology.
[74] L. Guarente,et al. Genetic links between diet and lifespan: shared mechanisms from yeast to humans , 2007, Nature Reviews Genetics.
[75] V. Giguère,et al. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. , 2004, Molecular and cellular biology.
[76] H. Berlie,et al. Evolution of Peroxisome Proliferator-Activated Receptor Agonists , 2007, The Annals of pharmacotherapy.
[77] A. Elsharkawy,et al. Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. , 2007, Hepatology.
[78] P. Tak,et al. Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. , 2008, Pharmacology & therapeutics.
[79] D. Ingram,et al. Caloric Restriction in Primates and Relevance to Humans , 2001, Annals of the New York Academy of Sciences.
[80] Myriam Gorospe,et al. Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase , 2004, Science.
[81] H. Chung,et al. The inflammation hypothesis of aging: molecular modulation by calorie restriction. , 2001, Annals of the New York Academy of Sciences.
[82] J. Auwerx,et al. PGC-1α Turbocharging mitochondria , 2004, Cell.
[83] D. Sinclair. Toward a unified theory of caloric restriction and longevity regulation , 2005, Mechanisms of Ageing and Development.
[84] Jimmy D Bell,et al. The integration of lipid-sensing and anti-inflammatory effects: how the PPARs play a role in metabolic balance , 2007, Nuclear receptor.
[85] Rafael A. Irizarry,et al. Bioinformatics and Computational Biology Solutions using R and Bioconductor , 2005 .
[86] I. Rahman,et al. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. , 2008, American journal of respiratory and critical care medicine.
[87] L. Guarente. Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins? , 2008, Cell.
[88] H. Chung,et al. Modulation of PPAR in aging, inflammation, and calorie restriction. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.
[89] P. Arner,et al. Tumour necrosis factor‐α in human adipose tissue – from signalling mechanisms to clinical implications , 2007, Journal of internal medicine.
[90] P. Puigserver. Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha. , 2005, International journal of obesity.
[91] Jacqueline Capeau,et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. , 2006, European cytokine network.
[92] Steve Hoberman,et al. A computational model to define the molecular causes of type 2 diabetes mellitus. , 2005, Diabetes technology & therapeutics.
[93] Gordon K Smyth,et al. Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .
[94] O. Mathieu-Costello,et al. Mitochondrial biogenesis during cellular differentiation. , 1997, The American journal of physiology.
[95] J. Auwerx,et al. PGC-1alpha: turbocharging mitochondria. , 2004, Cell.