Time Domain Measures of Heart Rate Variability to Assess Autonomic Dysfunction In Irritable Bowel Syndrome

Background: Autonomic nerve function impairment is related to development of Irritable Bowel Syndrome (IBS). Time domain measures of Heart rate variability (HRV) is a useful tool to measure autonomic nerve function activity. Objective: To assess autonomic nerve function activity by time domain measures of heart rate variability in patients with Irritable Bowel Syndrome. Methods: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka in 2011. Ninety patients aged 20-50 years of both sex with Irritable bowel syndrome were included in the study group. They were collected from the OPD of Gastroenterology in BSMMU. Age and sex matched 30 apparently healthy subjects served as control. For assessing HRV by time domain method, Mean heart rate Mean R-R interval, Max/Min R-R interval, SDNN, RMSSD, PNN50%, NN50% were recorded by a digital Polyrite. ANOVA, independent sample t-test and Pearson’s correlation coefficient tests were performed as applicable. Results: Mean heart rate were significantly higher and Mean R-R interval, Max/Min R-R interval, SDNN, RMSSD, PNN50%, NN50% were significantly lower in IBS groups compared to those of control. Correlation analysis showed negative correlations of SDNN, RMSSD, PNN50%, NN50% with duration of disease. Conclusion: This study concludes that parasympathetic activity was reduced in patients of IBS. In addition, decreased vagal modulation is inversely related to the duration IBS. DOI: http://dx.doi.org/10.3329/jbsp.v7i2.14451 J Bangladesh Soc Physiol. 2012, December; 7(2): 60-65

[1]  B. Polat,et al.  Heart rate variability in patients with rheumatoid arthritis , 2004, Rheumatology International.

[2]  T. Abell,et al.  Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities. , 1994, Gastroenterology.

[3]  G. Chrousos,et al.  The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system. , 2000, Pharmacological reviews.

[4]  M. Simrén,et al.  Functional findings in irritable bowel syndrome. , 2006, World journal of gastroenterology.

[5]  Robert L. Burr,et al.  Anxiety and Depression Are Related to Autonomic Nervous System Function in Women with Irritable Bowel Syndrome , 2003, Digestive Diseases and Sciences.

[6]  P A Low,et al.  Autonomic Nervous System Function , 1993, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[7]  S. Elsenbruch,et al.  Sleep-Related Autonomic Disturbances in Symptom Subgroups of Women with Irritable Bowel Syndrome , 2006, Digestive Diseases and Sciences.

[8]  A. Malliani,et al.  Heart rate variability. Standards of measurement, physiological interpretation, and clinical use , 1996 .

[9]  U. Wiklund,et al.  Spectral analysis of heart rate variability in patients with irritable bowel syndrome. , 1998, Scandinavian journal of gastroenterology.

[10]  M. DeLegge,et al.  Irritable bowel syndrome: a practical approach. , 2008, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[11]  M. Hansen.  The enteric nervous system I: organisation and classification. , 2003, Pharmacology & toxicology.

[12]  E. Mayer,et al.  Current insights into the pathophysiology of irritable bowel syndrome , 2003, Current gastroenterology reports.

[13]  M. Heitkemper,et al.  Autonomic Nervous System Function in Women with Irritable Bowel Syndrome , 2001, Digestive Diseases and Sciences.

[14]  M. A. Masud,et al.  Irritable Bowel Syndrome in a Bangladeshi Urban Community: Prevalence and Health Care Seeking Pattern , 2009, Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.