Chapter 3 Biosynthesis of Terpenoid Indole Alkaloids in Catharanthus roseus Cells

[1]  C. Larsson,et al.  The Plant Plasma Membrane , 2007, Springer Berlin Heidelberg.

[2]  G. Pasquali,et al.  Suspension cultured transgenic cells of Nicotiana tabacum expressing tryptophan decarboxylase and strictosidine synthase cDNAs from Catharanthus roseus produce strictosidine upon secologanin feeding , 1997, Plant Cell Reports.

[3]  R. Verpoorte,et al.  Strictosidine glucosidase from suspension cultured cells of Tabernaemontana divaricata , 1996 .

[4]  R. Verpoorte,et al.  Effects of elicitation on different metabolic pathways in Catharanthus roseus (L.)G.Don cell suspension cultures , 1996 .

[5]  S. Delrot,et al.  Isolation and characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl-coenzyme A synthase. , 1995, Gene.

[6]  B. St-Pierre,et al.  A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus , 1995, Plant physiology.

[7]  R. Last,et al.  Tryptophan biosynthesis and metabolism: biochemical and molecular genetics. , 1995, The Plant cell.

[8]  T. Kutchan,et al.  Alkaloid Biosynthesis[mdash]The Basis for Metabolic Engineering of Medicinal Plants. , 1995, The Plant cell.

[9]  J. Schmid,et al.  Molecular organization of the shikimate pathway in higher plants , 1995 .

[10]  I. Raskin,et al.  Biosynthesis and metabolism of salicylic acid. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[11]  R. Verpoorte,et al.  Terpenoid indole alkaloid biosynthesis and enzyme activities in two cell lines of Tabernaemontana divaricata , 1995 .

[12]  J. Phillipson,et al.  Anthranilate synthase in microorganisms and plants. , 1995, Phytochemistry.

[13]  R. Last,et al.  Immunological Characterization and Chloroplast Localization of the Tryptophan Biosynthetic Enzymes of the Flowering Plant Arabidopsis thaliana(*) , 1995, The Journal of Biological Chemistry.

[14]  A. de Waal,et al.  Strictosidine synthase from Catharanthus roseus: purification and characterization of multiple forms. , 1995, The Biochemical journal.

[15]  L. Heide,et al.  Intracellular localization of geranylpyrophosphate synthase from cell cultures of Lithospermum erythrorhizon , 1995 .

[16]  J. Chappell,et al.  The Biochemistry and Molecular Biology of Isoprenoid Metabolism , 1995, Plant physiology.

[17]  F. Karst,et al.  Isolation and characterization of a cDNA encoding Arabidopsis thaliana mevalonate kinase by genetic complementation in yeast. , 1994, Gene.

[18]  H. Kauss,et al.  Elicitation of 2,3‐Dihydroxybenzoic Acid and Ajmalicine in a Catharanthus roseus Suspension Culture* , 1994 .

[19]  F. Sasse,et al.  Are tissue cultures of Peganum harmala a useful model system for studying how to manipulate the formation of secondary metabolites , 1994 .

[20]  E. Farmer,et al.  Two Classes of Plant Antibiotics: Phytoalexins versus "Phytoanticipins" , 1994, The Plant cell.

[21]  D. Klessig,et al.  Salicylic acid, active oxygen species and systemic acquired resistance in plants. , 1994, Trends in cell biology.

[22]  V. Luca,et al.  2-oxoglutarate-dependent dioxygenase and related enzymes: biochemical characterization. , 1994 .

[23]  V. Luca,et al.  Ubiquitin-mediated degradation of tryptophan decarboxylase from Catharanthus roseus , 1994 .

[24]  J. Heijnen,et al.  Effects of oxygen and nutrients limitation on ajmalicine production and related enzyme activities in high density cultures of Catharanthus roseus , 1994, Biotechnology and bioengineering.

[25]  J. Chénieux,et al.  Cytokinin and Auxin-Induced Regulation of Protein Synthesis and Poly (A)+ RNA Accumulation in Catharanthus roseus Cell Cultures , 1994 .

[26]  R. J. Aerts,et al.  Methyl jasmonate vapor increases the developmentally controlled synthesis of alkaloids in Catharanthus and Cinchona seedlings , 1994 .

[27]  H. Chrestin,et al.  Long-Term Effect of a Pythium Elicitor Treatment on the Growth and Alkaloid Production of Catharanthus roseus Cell Suspensions. , 1994, Planta medica.

[28]  N. Brisson,et al.  Redirection of tryptophan leads to production of low indole glucosinolate canola. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[29]  R. Verpoorte,et al.  Ajmalicine metabolism in Catharanthus roseus cell cultures , 1994 .

[30]  R. Verpoorte,et al.  Terpenoid indole alkaloid biotransformation capacity of suspension cultures of Tabernaemontana divaricata , 1994 .

[31]  E. Haslam Shikimic Acid: Metabolism and Metabolites , 1993 .

[32]  H. Sahm,et al.  Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. , 1993, The Biochemical journal.

[33]  I. Maldonado-Mendoza,et al.  Expression of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene from Camptotheca acuminata Is Differentially Regulated by Wounding and Methyl Jasmonate , 1993, Plant physiology.

[34]  D. S. Bush,et al.  Regulation of Cytosolic Calcium in Plants , 1993, Plant physiology.

[35]  H. Sahm,et al.  Isoprenoid biosynthesis in bacteria: two different pathways? , 1993, FEMS microbiology letters.

[36]  Tetsuji Yamada,et al.  Rapid changes in polyphosphoinositide metabolism in pea in response to fungal signals , 1993 .

[37]  A. de Waal,et al.  Isolation and characterization of a cDNA clone from Catharanthus roseus encoding NADPH:cytochrome P-450 reductase, an enzyme essential for reactions catalysed by cytochrome P-450 mono-oxygenases in plants. , 1993, The Plant journal : for cell and molecular biology.

[38]  R. Verpoorte,et al.  Purification and characterization of strictosidine synthase from a suspension culture of Cinchona robusta , 1993 .

[39]  A. Meijer,et al.  Purification of the cytochrome P-450 enzyme geraniol 10-hydroxylase from cell cultures of Catharanthus roseus , 1993 .

[40]  E. De Carolis,et al.  Purification, characterization, and kinetic analysis of a 2-oxoglutarate-dependent dioxygenase involved in vindoline biosynthesis from Catharanthus roseus. , 1993, The Journal of biological chemistry.

[41]  R. Verpoorte,et al.  Purification and characterization of anthranilate synthase from Catharanthus roseus. , 1993, European journal of biochemistry.

[42]  K. Miyamoto,et al.  Effects of Near-Ultraviolet Light on Alkaloid Production in Catharanthus roseus Plants , 1993, Planta medica.

[43]  V. Luca,et al.  Partial purification of an N-methyltransferase involved in vindoline biosynthesis in Catharanthus roseus , 1993 .

[44]  T. Kutchan,et al.  Strictosidine: from alkaloid to enzyme to gene. , 1993, Phytochemistry.

[45]  H. Bull,et al.  Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by beta-lactone inhibitors and binding of these inhibitors to the enzyme. , 1993, The Biochemical journal.

[46]  R. Verpoorte,et al.  ALKALOID METABOLISM IN TABERNAEMONTANA DIVARICATA CELL SUSPENSION CULTURES , 1993 .

[47]  R. J. Aerts,et al.  Auxins induce tryptophan decarboxylase activity in radicles of catharanthus seedlings. , 1992, Plant physiology.

[48]  R. J. Aerts,et al.  Phytochrome is involved in the light-regulation of vindoline biosynthesis in catharanthus. , 1992, Plant physiology.

[49]  G. Schröder,et al.  Molecular Analysis and Heterologous Expression of an Inducible Cytochrome P-450 Protein from Periwinkle (Catharanthus roseus L.). , 1992, Plant physiology.

[50]  T. Furuya,et al.  Biotransformation of tabersonine in cell suspension cultures of Catharanthus roseus. , 1992, Phytochemistry.

[51]  H. Williams,et al.  Purification of an indole alkaloid biosynthetic enzyme, strictosidine synthase, from a recombinant strain of Escherichia coli. , 1992, Protein expression and purification.

[52]  M. Miranda-Ham,et al.  Serpentine Accumulation during Greening in Normal and Tumor Tissues of Catharanthus roseus , 1992 .

[53]  J. Mérillon,et al.  Effect of nifedipine on alkaloid accumulation in Catharanthus roseus cell cultures , 1992 .

[54]  Francisco A. Tomás-Barberán,et al.  Ecological chemistry and biochemistry of plant terpenoids , 1992 .

[55]  M. Zenk,et al.  Jasmonic acid is a signal transducer in elicitor-induced plant cell cultures. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[56]  R. Ibrahim,et al.  Immunocytochemical localization of vindoline in mesophyll protoplasts of Catharanthus roseus , 1992 .

[57]  F. Dicosmo,et al.  Purification and characterization of calmodulin from cultured cells of catharanthus roseus , 1991 .

[58]  R. Verpoorte,et al.  Alkaloid Production in Relation to Differentiation in Cell and Tissue Cultures of Tabernaemontana pandacaqui , 1991, Planta medica.

[59]  B. Parthier Jasmonates, New Regulators of Plant Growth and Development: Many Facts and Few Hypotheses on their Actions , 1991 .

[60]  F. Kargı,et al.  Effect of various stress factors on indole alkaloid formation by C. roseus (periwinkle) cells , 1991 .

[61]  R. Verpoorte,et al.  Uptake and accumulation of the alkaloids quinine and cinchonamine in cultured cells of Cinchona robusta and Catharanthus roseus , 1991 .

[62]  D. Bracher,et al.  Enzymology and molecular biology of alkaloid biosynthesis , 1991 .

[63]  G. Fink,et al.  Tryptophan mutants in Arabidopsis: the consequences of duplicated tryptophan synthase beta genes. , 1991, The Plant cell.

[64]  H. Kauss,et al.  Induced Ca2+ uptake and callose synthesis in suspension-cultured cells of Catharanthus roseus are decreased by the protein phosphatase inhibitor okadaic acid , 1991 .

[65]  R. White,et al.  Early steps of isoprenoid biosynthesis in Escherichia coli. , 1991, The Biochemical journal.

[66]  R. Verpoorte,et al.  Roles of chorismate mutase, isochorismate synthase and anthranilate synthase in plants , 1991 .

[67]  R. Verpoorte,et al.  Purification of Strictosidine Synthase from a Cinchona robusta Cell Suspension Culture , 1990 .

[68]  V. De Luca,et al.  Isolation and Characterization of a 2-Oxoglutarate Dependent Dioxygenase Involved in the Second-to-Last Step in Vindoline Biosynthesis. , 1990, Plant physiology.

[69]  N. Brisson,et al.  High levels of tryptamine accumulation in transgenic tobacco expressing tryptophan decarboxylase. , 1990, Plant physiology.

[70]  R. Verpoorte,et al.  N-Metabolism in Plant Cell Cultures of Tabernaemontana divaricata Investigated by Feeding [15 N]-Labelled Nitrate and Ammonium , 1990 .

[71]  T. McKnight,et al.  Nucleotide sequence of a cDNA encoding the vacuolar protein strictosidine synthase from Catharanthus roseus. , 1990, Nucleic acids research.

[72]  R. Power,et al.  Purification and characterization of acetylcoenzyme A: deacetylvindoline 4-O-acetyltransferase from Catharanthus roseus. , 1990, Archives of biochemistry and biophysics.

[73]  H. Yu,et al.  Sequence analysis of ripening-related cytochrome P-450 cDNAs from avocado fruit. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[74]  R. Verpoorte,et al.  Developmental regulation of alkaloid production in Cinchona seedlings. , 1990 .

[75]  F. Kargı,et al.  Recent Advances in Indole Alkaloid Production by Catharanthus roseus (Periwinkle) , 1990 .

[76]  M. Zenk,et al.  Homogeneous Strictosidine Synthase Isoenzymes from Cell Suspension Cultures of Catharanthus roseus , 1989, Planta medica.

[77]  T. Kutchan Expression of enzymatically active cloned strictosidine synthase from the higher plant Rauvolfia serpentina in Escherichia coli , 1989, FEBS letters.

[78]  K. McCue,et al.  Induction of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase activity by fungal elicitor in cultures of Petroselinum crispum. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[79]  J. Fernández,et al.  Conformation-dependent inactivation of tryptophan decarboxylase from Catharanthus roseus , 1989 .

[80]  R. Verpoorte,et al.  Tryptophan decarboxylase from Catharanthus roseus is a pyridoxoquinoprotein , 1989 .

[81]  V. De Luca,et al.  Immunological Detection and Quantitation of Tryptophan Decarboxylase in Developing Catharanthus roseus Seedlings. , 1989, Plant physiology.

[82]  J. Hamill,et al.  Alkaloid Production by Transformed Root Cultures of Cinchona ledgeriana , 1989, Planta medica.

[83]  C. Viel,et al.  Time-Course Studies on The Use of Secologanin by Catharanthus roseus Cells Cultured in vitro , 1989 .

[84]  Y. Bajaj,et al.  Medicinal and Aromatic Plants II , 1989, Biotechnology in Agriculture and Forestry.

[85]  V. Kauppinen,et al.  Mass Spectral Evidence of the Occurrence of Vindoline in Heterotrophic Cultures of Catharanthus roseus Cells. , 1989, Planta medica.

[86]  C. Marineau,et al.  Molecular cloning and analysis of cDNA encoding a plant tryptophan decarboxylase: comparison with animal dopa decarboxylases. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[87]  H. Fretz,et al.  The Allylic Oxidation of Geraniol Catalyzed by Cytochrome P‐450Cath., Proceeding with retention of configuration , 1989 .

[88]  J. Mérillon,et al.  Metabolic Changes and Alkaloid Production in Habituated and Non-habituated Cells of Catharanthus roseus Grown in Hormone-free Medium. Comparing Hormone-deprived Non-habituated Cells with Habituated Cells , 1989 .

[89]  N. Hampp,et al.  The cDNA clone for strictosidine synthase from Rauvolfia serpentina DNA sequence determination and expression in Escherichia coli , 1988, FEBS letters.

[90]  A. Scragg,et al.  Growth and secondary product formation of a selected Catharanthus roseus cell line , 1988 .

[91]  D. McCaskill,et al.  Characterization of Alkaloid Uptake by Catharanthus roseus (L.) G. Don Protoplasts. , 1988, Plant physiology.

[92]  A. Goodbody,et al.  Enzymic coupling of catharanthine and vindoline to form 3',4'-anhydrovinblastine by horseradish peroxidase. , 1988, Planta medica.

[93]  D. Campbell,et al.  Developmental Regulation of Enzymes of Indole Alkaloid Biosynthesis in Catharanthus roseus. , 1988, Plant physiology.

[94]  A. Cutler,et al.  Subcellular Localization of Enzymes Involved in Indole Alkaloid Biosynthesis in Catharanthus roseus. , 1987, Plant physiology.

[95]  A. Goodbody,et al.  Alkaloid Production in Root and Shoot Cultures of Catharanthus roseus. , 1987, Planta medica.

[96]  N. J. Smart,et al.  Stimulation of Indole Alkaloid Production in Cell Suspension Cultures of Catharanthus roseus by Abscisic Acid. , 1987, Planta medica.

[97]  U. Eilert,et al.  Elicitor-mediated induction of tryptophan decarboxylase and strictosidine synthase activities in cell suspension cultures of Catharanthus roseus. , 1987, Archives of biochemistry and biophysics.

[98]  M. Zenk,et al.  Radioimmunoassay for the Quantitative Determination of Catharanthine , 1987, Planta medica.

[99]  F. Dicosmo,et al.  Increased synthesis of ajmalicine and catharanthine by cell suspension cultures ofCatharanthus roseus in response to fungal culture-filtrates , 1987, Applied biochemistry and biotechnology.

[100]  H. Fretz,et al.  Regioselectivity and deuterium isotope effects in geraniol hydroxylation by the cytochrome P-450 monooxygenase from Catharanthus roseus (L.) G. Don , 1986 .

[101]  U. Eilert,et al.  Elicitor-stimulation of monoterpene indole alkaloid formation in suspension cultures of Catharanthus roseus , 1986 .

[102]  R. Tyler,et al.  Biosynthesis of Indole Alkaloids: Developmental Regulation of the Biosynthetic Pathway from Tabersonine to Vindoline in Catharanthus roseus , 1986 .

[103]  B. Liedvogel Acetyl Coenzyme A and Isopentenylpyrophosphate as Lipid Precursors in Plant Cells - Biosynthesis and Compartmentation , 1986 .

[104]  R. Hall,et al.  FACTORS DETERMINING ANTHOCYANIN YIELD IN CELL CULTURES OF CATHARANTHUSROSEUS (L.)G. DON. , 1986 .

[105]  B. Mersey,et al.  Differential distribution of specific indole alkaloids in leaves of Catharanthus roseus , 1986 .

[106]  Phillip Morris,et al.  Regulation of Product Synthesis in Cell Cultures of Catharanthus roseus. II. Comparison of Production Media1 , 1986 .

[107]  V. Luca,et al.  Acetyl Coenzyme A: Deacetylvindoline O-Acetyltransferase, A Novel Enzyme from Catharanthus , 1985 .

[108]  B. Singh,et al.  Chorismate mutase isoenzymes from Sorghum bicolor: purification and properties. , 1985, Archives of biochemistry and biophysics.

[109]  M. Zenk,et al.  Intermediacy of 10-hydroxygeraniol, 10-hydroxynerol and iridodial in the biosynthesis of ajmaline and vomilenine in Rauwolfia serpentina suspension cultures , 1984 .

[110]  S. Uesato,et al.  MECHANISM FOR IRIDANE SKELETON FORMATION FROM ACYCLIC MONOTERPENES IN THE BIOSYNTHESIS OF SECOLOGANIN AND VINDOLINE IN CATHARANTHUS ROSEUS AND LONICERA MORROWII , 1984 .

[111]  J. Balsevich,et al.  The Role of 9- and/or 10-oxygenated Derivatives of Geraniol, Geranial, Nerol, and Neral in the Biosynthesis of Loganin and Ajmalicine , 1983, Planta medica.

[112]  T. Hemscheidt,et al.  Steric course of hydrogen transfer during enzymatic formation of 3.alpha.-heteroyohimbine alkaloids , 1983 .

[113]  N. Lewis,et al.  Biosynthesis of the Indole Alkaloids. Cell‐free Systems from Catharanthus roseus Plants , 1982 .

[114]  M. Zenk,et al.  Immobilization of Strictosidine Synthase from Catharanthus Cell Cultures and Preparative Synthesis of Strictosidine , 1982, Planta medica.

[115]  T. Mulder-Krieger,et al.  Identification of the Alkaloids and Anthraquinones in Cinchona ledgeriana Callus Cultures , 1982, Planta medica.

[116]  J. Kutney,et al.  Alkaloid Production in Catharanthus Roseus Cell Cultures. XI. Biotransformation of 3′, 4′‐Anhydrovinblastine to Other Bisindole Alkaloids , 1982 .

[117]  L. Tietze,et al.  Untersuchungen zur Biogenese der Indolalkaloide. Synthese und Verfütterung radioaktiv markierter Hydroxyloganin‐Derivate1) , 1981 .

[118]  T. Tanahashi,et al.  Studies on Monoterpene Glucosides and Related Natural Products. XLII. On the Possibility of the Intermediacy of 10-Hydroxyloganin in the Biosynthesis of Secologanin , 1981 .

[119]  J. Meisner,et al.  Phagodeterrency Induced by Leaves and Leaf Extracts of Catharanthus roseus in the Larva of Spodoptera littoralis , 1981 .

[120]  M. Zenk Enzymatic Synthesis of Ajmalicine and Related Indole Alkaloids , 1980 .

[121]  M. Zenk,et al.  Radioimmunoassay for the Determination of the Indole Alkaloid Vindoline in Catharanthus , 1980 .

[122]  M. Zenk,et al.  Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures , 1980, FEBS letters.

[123]  M. Zenk,et al.  Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation. , 1979, European journal of biochemistry.

[124]  A. Scott,et al.  Purification and properties of strictosidine synthetase (an enzyme condensing tryptamine and secologanin) from Catharanthus roseus cultured cells. , 1979, Biochemistry.

[125]  C. Coscia,et al.  Detergent-solubilized NADPH-cytochrome c(P-450) reductase from the higher plant, Catharanthus roseus. Purification and characterization. , 1979, The Journal of biological chemistry.

[126]  J. Carlson,et al.  Separation of Two Forms of Anthranilate Synthetase from 5‐Methyltryptophar Susceptible and ‐Resistant Cultured Solarium tuberosumCells , 1978 .

[127]  A. Scott,et al.  Role of anhydrovinblastine in the biosynthesis of the antitumor dimeric indole alkaloids , 1978 .

[128]  M. Zenk,et al.  Isovincoside (strictosidine), the key intermediate in the enzymatic formation of indole alkaloids , 1977 .

[129]  A. Scott,et al.  Indole alkaloid biosynthesis: Partial purification of “ajmalicine synthetase” from Catharanthus roseus , 1977 .

[130]  C. Coscia,et al.  Subcellular localization of a cytochrome P-450-dependent monogenase in vesicles of the higher plant Catharanthus roseus , 1977, The Journal of cell biology.

[131]  P. Mahlberg,et al.  REACTIONS OF ALKALOID AND HISTOCHEMICAL INDICATORS IN LATICIFERS AND SPECIALIZED PARENCHYMA CELLS OF CATHARANTHUS ROSEUS (APOCYNACEAE) , 1976 .

[132]  T. Meehan,et al.  Characterization of a cytochrome P-450 dependent monoterpene hydroxylase from the higher plant Vinca rosea. , 1976, Biochemistry.

[133]  K. Kobayashi,et al.  Studies on monoterpene glucosides and related natural products. XXX. The fate of the C-8 proton of 7-deoxyloganic acid in the biosynthesis of secoiridoid glucosides. , 1976 .

[134]  E. Leistner,et al.  ISOLIERUNG, IDENTIFIZIERUNG UND BIOSYNTHESE VON ANTHRACHINONEN IN ZELLSUSPENSIONSKULTUREN VON MORINDA CITRIFOLIA , 1975, Planta medica.

[135]  C. Coscia,et al.  Regulation of secondary metabolism in higher plants. Effect of alkaloids on a cytochrome P-450 dependent monooxygenase. , 1975, Biochemical and biophysical research communications.

[136]  L. Botta,et al.  Biosynthesis of acidic iridoid monoterpene glucosides in Vinca Rosea , 1974 .

[137]  P. Daddona,et al.  Biosynthesis of camptothecin. I. Definition of the overall pathway assisted by carbon-13 nuclear magnetic resonance analysis. , 1974, Journal of the American Chemical Society.

[138]  Cordell Ga The biosynthesis of indole alkaloids. , 1974 .

[139]  Y. Takeda,et al.  Studies on Monoterpene Glucosides and Related Natural Products. XXIII. Biosynthesis of the Secoiridoid Glucosides, Gentiopicroside, Morroniside, Oleuropein, and Jasminin , 1974 .

[140]  T. Meehan,et al.  Hydroxylation of geraniol and nerol by a monooxygenase from Vinca rosea. , 1973, Biochemical and biophysical research communications.

[141]  P. Mazliak LIPID METABOLISM IN PLANTS , 1973 .

[142]  C. Baxter,et al.  S-Adenosyl-L-methionine: loganic acid methyltransferase. A carboxyl-alkylating enzyme from Vinca rosea. , 1973, The Journal of biological chemistry.

[143]  J. Harwood 6 – Plant Lipid Metabolism , 1997 .

[144]  R. Verpoorte,et al.  Reaction for the localization of strictosidine glucosidase activity on polyacrylamide gels , 1996 .

[145]  M. Arvy,et al.  2,4-D and alkaloid accumulation in periwinkle cell suspensions. , 1994, Biochimie.

[146]  R. Verpoorte,et al.  Biosynthesis of 3S-hydroxy-3-methylglutaryl-coenzyme A in Catharanthus roseus: acetoacetyl-CoA thiolase and HMG-CoA synthase show similar chromatographic behaviour , 1994 .

[147]  G. Spangenberg,et al.  Gene and cDNA for plant cytochrome P450 proteins (CYP72 family) from Catharanthus roseus, and transgenic expression of the gene and a cDNA in tobacco and Arabidopsis thaliana , 1994 .

[148]  T. Kutchan,et al.  Heterologous expression of the plant proteins strictosidine synthase and berberine bridge enzyme in insect cell culture. , 1994, Phytochemistry.

[149]  Masaki Ito,et al.  Studies of the Plant Cell Cycle in Synchronous Cultures of Catharanthus roseus Cells , 1994 .

[150]  Johann Eder,et al.  Elicitors of Plant Defense Responses , 1994 .

[151]  H. Chang,et al.  PRODUCTION AND SECRETION OF INDOLE ALKALOIDS IN HAIRY ROOT CULTURES OF CATHARANTHUS-ROSEUS - EFFECTS OF IN-SITU ADSORPTION, FUNGAL ELICITATION AND PERMEABILIZATION , 1994 .

[152]  R. Verpoorte,et al.  Induction of the Secondary Metabolism in Catharanthus roseus Cell Suspension Cultures in Response to UV Irradiation and the Addition of a Benzoic Acid Derivative , 1994 .

[153]  I. Vasil Plant Cell and Tissue Culture , 1994, Springer Netherlands.

[154]  B. Parthier,et al.  The Biochemistry and the Physiological and Molecular Actions of Jasmonates , 1993 .

[155]  D. Scheel,et al.  Studies on elicitor recognition and signal transduction in plant defence , 1993 .

[156]  駒嶺 穆 Cellular and molecular biology in plant cell cultures , 1993 .

[157]  J. Mérillon,et al.  Modulation by cytokinin of membrane lipids in Catharanthus roseus cells , 1993 .

[158]  K. Miyamoto,et al.  Stimulation of dimeric alkaloid production by near-ultraviolet light in multiple shoot cultures of Catharanthus roseus. , 1992 .

[159]  R. Verpoorte,et al.  Activities of chorismate utilizing enzymes and of enzymes involved in indole alkaloid biosynthesis in cell suspension cultures , 1992 .

[160]  R. Verpoorte,et al.  Activities of enzymes involved in indole alkaloid biosynthesis in suspension cultures of Catharanthus, Cinchona and Tabernaemontana species , 1992 .

[161]  Sarah J. Gurr,et al.  Molecular plant pathology : a practical approach , 1992 .

[162]  I. Maldonado-Mendoza,et al.  Plant GeneRegister Nucleotide Sequence ofa cDNA Encoding 3-Hydroxy-3-Methylglutaryl CoenzymeA Reductase from Catharanthus roseus' , 1992 .

[163]  R. Verpoorte,et al.  Nitrogen metabolism in cultures of Tabernaemontana divaricata , 1991 .

[164]  S. Auriola,et al.  Growth-related dimerization of vindoline and catharanthine in Catharanthus roseus and effect of wounding on the process , 1991 .

[165]  R. Verpoorte,et al.  Control and biological implications of alkaloid synthesis inCinchona seedlings , 1991 .

[166]  S. Hertel,et al.  Purification and characterization of chorismate mutase isoenzymes from ruta graveolens l. , 1991 .

[167]  R. Verpoorte,et al.  Allelopathic inhibition of seed germination by Cinchona alkaloids , 1991 .

[168]  C. Nessler,et al.  Tyramine accumulation in Nicotiana tabacum transformed with a chimeric tryptophan decarboxylase gene , 1991 .

[169]  J. Mérillon,et al.  Effects of calcium entry blockers and calmodulin inhibitors on cytokinin-enhanced alkaloid accumulation in Catharanthus roseus cell cultures , 1991 .

[170]  T. Waldmann,et al.  THE PHYTOTOXIN SYRINGOMYCIN ELICITS CA2+-DEPENDENT CALLOSE SYNTHESIS IN SUSPENSION-CULTURED CELLS OF CATHARANTHUS ROSEUS , 1991 .

[171]  W. R. van Zwet,et al.  Modelling the growth of a batch culture of plant cells: A corpuscular approach , 1990 .

[172]  K. Bozak Sequence analysis of ripening-related cytochrom P450 form avacado fruit. , 1990 .

[173]  R. Verpoorte,et al.  Formation and degradation of some aspidospermatan indole alkaloids in a suspension culture of Tabernaemontana divaricata. , 1990 .

[174]  Wolfgang G. W. Kurz,et al.  Primary and Secondary Metabolism of Plant Cell Cultures II , 1989, Springer Berlin Heidelberg.

[175]  R. Verpoorte,et al.  Purification of tryptophan decarboxylase from a Catharanthus roseus cell suspension culture , 1989 .

[176]  D. Gunst A random model for plant cell population growth , 1989 .

[177]  T. Tanahashi,et al.  Intermediacy of 6-hydroxyloganin in the ring cleavage course of loganin to secologanin , 1989 .

[178]  S. Kelly,et al.  Cytochrome P-450 inducer/inhibitor effects on cell cultures of Catharanthus roseus , 1989 .

[179]  H. Kleinig The Role of Plastids in Isoprenoid Biosynthesis , 1989 .

[180]  H. Sahm,et al.  Bacterial sterol surrogates. Biosynthesis of the side-chain of bacteriohopanetetrol and of a carbocyclic pseudopentose from 13C-labelled glucose in Zymomonas mobilis , 1989 .

[181]  R. Verpoorte,et al.  Regulation and enzymology of pentacyclic triterpenoid phytoalexin biosynthesis in cell suspension cultures of Tabernaemontana divaricata , 1989 .

[182]  R. Jensen,et al.  Evidence from Solanum tuberosum in Support of the Dual-Pathway Hypothesis of Aromatic Biosynthesis. , 1989, Plant physiology.

[183]  T. Nikaido,et al.  Alkaloid Production in Catharanthus roseus (L.) G. Don Cell Cultures. XVI. Biotransformation of 3',4'-Anhydrovinblastine with Catharanthus roseis Cell Cultures and Enzyme Systems , 1988 .

[184]  T. Nikaido,et al.  Alkaloid Production in Catharanthus roseus (L.) G. Don Cell Cultures. XIV. The Role of Unstable Dihydropyridinium Intermediates in the Biosynthesis of Bisindole Alkaloids , 1988 .

[185]  J. Gray Control of Isoprenoid Biosynthesis in Higher Plants , 1988 .

[186]  H. Tsukamoto,et al.  Biomimetic Chemical Transformation of 3',4'-Anhydrovinblastine to Vinblastine and Related Bisindole Alkaloids , 1988 .

[187]  A. Goodbody,et al.  Enzymes from Catharanthus roseus cell suspension cultures that couple vindoline and catharanthine to form 3′,4′-anhydrovinblastine , 1988 .

[188]  S. Mclean,et al.  Peroxidase from bioreactor-cultivated Catharanthus roseus cell cultures mediates biosynthesis of alpha-3',4'-anhydrovinblastine , 1988 .

[189]  T. Nikaido,et al.  Alkaloid Production in Catharanthus roseus (L.) G. Don Cell Cultures. XV. Synthesis of Bisindole Alkaloids by Use of Immobilized Enzyme Systems , 1988 .

[190]  A. Goodbody,et al.  Synthesis of dimeric indole alkaloids by cell free extracts from cell suspension cultures of Catharanthus roseus , 1988 .

[191]  N. Hampp,et al.  Homogeneous strictosidine synthase from cell suspension cultures of Rauvolfia serpentina , 1988 .

[192]  M. Zenk,et al.  Elucidation of iridodial formation mechanism - partial purification and characterization of the novel monoterpene cyclase from rauwolfia serpentina cell suspension cultures , 1987 .

[193]  A. D. Cunha The estimation of l-phenylalanine ammonia-lyase shows phenylpropanoid biosynthesis to be regulated by l-phenylalanine supply and availability , 1987 .

[194]  P. Frischknecht,et al.  Effect of drought and wounding stress on indole alkaloid formation in Catharanthus roseus , 1987 .

[195]  A. Goodbody,et al.  Biotransformation of anhydrovinblastine to vinblastine by a cell-free extract of Catharanthus roseus cell suspension cultures , 1987 .

[196]  P. Morris Secondary metabolism in plant cell cultures , 1986 .

[197]  M. Zenk,et al.  Synthesis of iridodial by cell free extracts from Rauwolfia serpentina cell suspension cultures , 1986 .

[198]  Akira Iida,et al.  Mechanism for iridane skeleton formation in the biosynthesis of secologanin and indole alkaloids in Lonicera tatarica, Catharanthus roseus and suspension cultures of Rauwolfia serpentina , 1986 .

[199]  J. Balsevich,et al.  Altered alkaloid pattern in dark grown seedlings of Catharanthus roseus: the isolation and characterization of 4-desacetoxyvindoline: a novel indole alkaloid and proposed precursor of vindoline , 1986 .

[200]  M. M. Yeoman,et al.  Temporal and Spatial Heterogeneity in the Accumulation of Anthocyanins in Cell Cultures of Catharanthus roseus (L.) G.Don. , 1986 .

[201]  H. Miziorko 3-Hydroxy-3-methylglutaryl-CoA synthase from chicken liver. , 1985, Methods in enzymology.

[202]  E. Reinhard,et al.  Primary and Secondary Metabolism of Plant Cell Cultures , 1985, Proceedings in Life Sciences.

[203]  M. Zenk,et al.  Biosynthesis of anthraquinones and related compounds in Galium mollugo cell suspension cultures , 1984 .

[204]  R. Larson,et al.  Quenching of singlet oxygen by alkaloids and related nitrogen heterocycles , 1984 .

[205]  L. Bogorad,et al.  Cell culture and somatic cell genetics of plants , 1984 .

[206]  R. Baxter,et al.  Conversion of anhydrovinblastine to vinblastine by cell-free homogenates of catharanthus roseus cell suspension cultures , 1983 .

[207]  Atta-ur- Rahman,et al.  Biosynthesis of indole alkaloids , 1983 .

[208]  J. Stöckigt,et al.  Partial purification and characterization of geissoschizine dehydrogenase from suspension cultures of Catharanthus roseus , 1982 .

[209]  K. Knobloch,et al.  Medium- and light-induced formation of serpentine and anthocyanins in cell suspension cultures of Catharanthus roseus , 1982 .

[210]  James P. Kutney,et al.  Alkaloid Production in Catharanthus roseus Cell Cultures. IX. Biotransformation Studies with 3',4'-Dehysdrovinblastine , 1981 .

[211]  T. Hirata,et al.  Biosynthesis of triterpenoids from amino acids in Pisum sativum. The distribution of the radioactivity in squalene biosynthesized from radioisotopically labelled l-leucine and l-valine , 1980 .

[212]  G. Höfle,et al.  Mechanism of the biosynthetic conversion of geissoschizine to 19-epi-ajmalicine in , 1980 .

[213]  M. Zenk,et al.  Indole and biogenetically related alkaloids , 1980 .

[214]  M. Zenk,et al.  4,21-Dehydrogeissoschizine, an intermediate in heteroyohimbine alkaloid biosynthesis , 1979 .

[215]  J. Stöckigt Enzymatic formation of intermediates in the biosynthests of ajmalicine: Strictosidine and cathenamine , 1979 .

[216]  R. T. Brown,et al.  Biomimetic synthesis of cathenamine and 19-epicathenamine, key intermediates to heteroyohimbine alkaloids , 1979 .

[217]  H. Husson,et al.  Isolation and biomimetic conversion of 4,21-dehydrogeissoschizine , 1979 .

[218]  M. Zenk,et al.  Strictosidine synthase from cell cultures of apocynaceae plants , 1979 .

[219]  M. Zenk,et al.  Indirect Identification of 4,21–Dehydrocorynantheine Aldehyde as an Intermediate in the Biosynthesis of Ajmalicine and Related Alkaloids , 1978 .

[220]  C. Hutchinson,et al.  Biosynthesis of the dimeric indole alkaloids. II. Catharanthine as a precursor of vincaleukoblastine. , 1978 .

[221]  T. Honda,et al.  Intermediacy of 3’,4’-Dehydrovinblastine in the Biosynthesis of Vinblastine-Type Alkaloids , 1978 .

[222]  T. Honda,et al.  Studies on the Biosynthesis of Bisindole Alkaloids. The Final Stages in Biosynthesis of Vinblastine, Leurosine and Catharine , 1978 .

[223]  J. Stöckigt Indirect involvement of geissoschizine in the biosynthesis of ajmalicine and related alkaloids , 1978 .

[224]  M. Zenk,et al.  Cathenamine, a central intermediate in the cell free biosynthesis of ajmalicine and related indole alkaloids , 1977 .

[225]  C. Hutchinson,et al.  The Role of Isovincoside (Strictosidine) in the Biosynthesis of the Indole Alkaloids , 1977 .

[226]  M. Zenk,et al.  Strictosidine (isovincoside): the key intermediate in the biosynthesis of monoterpenoid indole alkaloids , 1977 .

[227]  P. Daddona,et al.  Alkaloid catabolism and mobilization in catharanthus roseus , 1976 .

[228]  M. Lane,et al.  [21] Cytosolic acetoacetyl-CoA thiolase from chicken liver , 1975 .

[229]  N. Kunesch,et al.  Rearrangement de la (−) tabersonine en milieu acetique , 1972 .

[230]  J. S. Hill,et al.  On the rearrangement of catharanthine, stemmadenine and tabersonine in acetic acid , 1971 .

[231]  H. Inouye,et al.  Zur biosynthese des morronisids , 1971 .

[232]  J. S. Hill,et al.  Rearrangement of catharanthine, stemmadenine, and tabersonine in acetic acid , 1969 .

[233]  A. Battersby,et al.  The intermediacy of geissoschizine in indole alkaloid biosynthesis: rearrangement to the Strychnos skeleton , 1969 .