Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine.

The human cell line HL-60 was used to investigate the role of protein kinase C in the regulation of retinoic acid-induced maturation of promyelocytic leukemia cells by growth and differentiation factors found in serum. Cells grown in serum-containing medium differentiated less than cells in serum-free medium due to several factors, including albumin binding of retinoic acid. Addition of an inhibitor (sphinganine) of protein kinase C, an enzyme that participates in cellular responses to many serum factors, facilitated the retinoic acid-induced differentiation. Cells treated with both retinoic acid and sphinganine produced more superoxide when stimulated by formylmethionylleucylphenylalanine; hence, this combination generated a more functional population of cells. The ability of sphinganine to promote retinoic acid-induced differentiation suggests that retinoic acid therapy might be improved by the concurrent use of a modulator of protein kinase C activity.

[1]  M. Kizaki,et al.  [Induction of differentiation of human leukemia cells]. , 1992, Human cell.

[2]  V. Stevens,et al.  Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human leukemia (HL-60) cells induced by phorbol esters, 1 alpha, 25-dihydroxyvitamin D3, or ganglioside GM3. , 1989, Cancer research.

[3]  V. Stevens,et al.  Modulation of protein kinase C and diverse cell functions by sphingosine--a pharmacologically interesting compound linking sphingolipids and signal transduction. , 1989, Biochimica et biophysica acta.

[4]  F. Hall,et al.  Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C. , 1988, The Journal of biological chemistry.

[5]  J. A. Badwey,et al.  Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release. , 1988, The Journal of biological chemistry.

[6]  M. Civan,et al.  Insulin and phorbol ester stimulate conductive Na+ transport through a common pathway. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[7]  E. Freireich,et al.  HL-60 cell line was derived from a patient with FAB-M2 and not FAB-M3. , 1988, Blood.

[8]  J. Niedel,et al.  Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils. , 1988, Journal of immunology.

[9]  P. Sims,et al.  Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases. , 1987, The Journal of biological chemistry.

[10]  Y. Hannun,et al.  Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. , 1987, The Journal of biological chemistry.

[11]  R. S. Tan,et al.  Induction of virus enzymes by phorbol esters and n-butyrate in Epstein-Barr virus genome-carrying Raji cells. , 1987, Cancer research.

[12]  J. Marx.  Human trials of new cancer therapy begin. , 1987, Science.

[13]  M. Tyers,et al.  Induction of the 47 kDa platelet substrate of protein kinase C during differentiation of HL-60 cells. , 1987, The Biochemical journal.

[14]  S. Lippman,et al.  Retinoids as preventive and therapeutic anticancer agents (Part I). , 1987, Cancer treatment reports.

[15]  H. Hemmi,et al.  Combinations of recombinant human interferons and retinoic acid synergistically induce differentiation of the human promyelocytic leukemia cell line HL-60. , 1987, Blood.

[16]  D. K. Ways,et al.  Lipoprotein modulation of the intracellular localization of protein kinase C and alteration of phorbol ester-stimulated differentiation in the human monoblastic U937 cell line. , 1986, Cancer research.

[17]  Y. Hannun,et al.  Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. , 1986, The Journal of biological chemistry.

[18]  Y. Hannun,et al.  Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. , 1986, The Journal of biological chemistry.

[19]  A. Merrill,et al.  Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst. , 1986, The Journal of biological chemistry.

[20]  J. Hesketh,et al.  Rapid response of protein synthesis to insulin in 3T3 cells: Effects of protein kinase C depletion and differences from the response to serum repletion , 1986, Bioscience reports.

[21]  D. Nelson,et al.  Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose. , 1986, Biochemical and biophysical research communications.

[22]  M. Imaizumi,et al.  A combination of a T cell-derived lymphokine differentiation-inducing activity and a physiologic concentration of retinoic acid induces HL-60 to differentiate to cells with functional chemotactic peptide receptors. , 1986, Blood.

[23]  M. Veigl,et al.  Induction of myeloid differentiation of HL-60 cells with naphthalene sulfonamide calmodulin antagonists. , 1986, Cancer research.

[24]  T. Okazaki,et al.  Effect of antimetabolites and thymidine blockage on the induction of differentiation of HL-60 cells by retinoic acid or 1 alpha,25-dihydroxyvitamin D3. , 1985, Experimental Hematology.

[25]  R. Glazer,et al.  Phospholipid- and Ca2+-dependent protein kinase activity and protein phosphorylation patterns in the differentiation of human promyelocytic leukemia cell line HL-60. , 1985, Cancer research.

[26]  G. S. Johnson,et al.  Retinoic acid-induced expression of tissue transglutaminase in human promyelocytic leukemia (HL-60) cells. , 1985, The Journal of biological chemistry.

[27]  Peter Ralph,et al.  Human Leukemic Models of Myelomonocytic Development: A Review of the HL‐60 and U937 Cell Lines , 1985, Journal of leukocyte biology.

[28]  R. Bell,et al.  Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[29]  K L Albright,et al.  Membrane origin for a signal eliciting a program of cell differentiation. , 1984, Experimental cell research.

[30]  R. Branda,et al.  Retinoic acid treatment of acute promyelocytic leukemia: in vitro and in vivo observations. , 1983, Blood.

[31]  R. Mertelsmann,et al.  Phase I clinical trial of 13-cis-retinoic acid in myelodysplastic syndromes. , 1983, Cancer treatment reports.

[32]  H. Koeffler.  Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications , 1983 .

[33]  Y. Honma,et al.  Modification by serum of differentiation of cultured human myeloid leukemia cells in response to 12-O-tetradecanoylphorbol-13-acetate. , 1982, Gan.

[34]  J. August,et al.  Dexamethasone synergistically induces chemotactic peptide receptor expression in HL-60 cells. , 1982, Blood.

[35]  S. Collins,et al.  Terminal Differentiation of Human Promyelocytic Leukemic Cells in Primary Culture in Response to Retinoic Acid , 1981 .

[36]  S. Collins,et al.  Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[37]  D Barnes,et al.  Methods for growth of cultured cells in serum-free medium. , 1980, Analytical biochemistry.

[38]  A. Rizzino,et al.  Growth and differentiation of embryonal carcinoma cell line F9 in defined media. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[39]  S. Strickland,et al.  The induction of differentiation in teratocarcinoma stem cells by retinoic acid , 1978, Cell.

[40]  S. Collins,et al.  Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture , 1977, Nature.

[41]  F. Chytil,et al.  Retinoic acid-binding protein in rat tissue. Partial purification and comparison to rat tissue retinol-binding protein. , 1975, The Journal of biological chemistry.