Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death

[1]  B. Brüne,et al.  Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages , 2021, Frontiers in Immunology.

[2]  J. Sznajder,et al.  The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging. , 2021, The Journal of clinical investigation.

[3]  D. Figarella-Branger,et al.  SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution. , 2020, Cell metabolism.

[4]  J. Köhl,et al.  GM-CSF and IL-33 Orchestrate Polynucleation and Polyploidy of Resident Murine Alveolar Macrophages in a Murine Model of Allergic Asthma , 2020, International journal of molecular sciences.

[5]  B. Au,et al.  Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations , 2020, Communications Biology.

[6]  H. Dawson,et al.  Potentiation of IL-4 Signaling by Retinoic Acid in Intestinal Epithelial Cells and Macrophages—Mechanisms and Targets , 2020, Frontiers in Immunology.

[7]  C. Roskelley,et al.  CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation , 2020, Frontiers in Immunology.

[8]  Matthew R. Jones,et al.  Pneumonia recovery reprograms the alveolar macrophage pool. , 2020, JCI insight.

[9]  M. Mack,et al.  Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection , 2019, Nature Immunology.

[10]  R. Månsson,et al.  Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self‐renewal and identity , 2019, The EMBO journal.

[11]  A. Ivens,et al.  The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation , 2019, Nature Immunology.

[12]  A. Jobe,et al.  The Surfactant System , 2019, Kendig's Disorders of the Respiratory Tract in Children.

[13]  L. Lanier,et al.  Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition , 2018, Nature Communications.

[14]  I. Amit,et al.  Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting , 2018, Cell.

[15]  A. Makrigiannis,et al.  NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections , 2018, Cellular & Molecular Immunology.

[16]  B. Trapnell,et al.  Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis , 2018, Nature Communications.

[17]  M. Guilliams,et al.  Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function , 2018, Cell reports.

[18]  Y. Inoue,et al.  Pulmonary alveolar proteinosis in adults: pathophysiology and clinical approach. , 2018, The Lancet. Respiratory medicine.

[19]  J. Moffat,et al.  The Inhibitory NKR-P1B:Clr-b Recognition Axis Facilitates Detection of Oncogenic Transformation and Cancer Immunosurveillance. , 2018, Cancer research.

[20]  D. Metzger,et al.  IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells , 2017, Mucosal Immunology.

[21]  B. Becher,et al.  The Cytokine TGF‐&bgr; Promotes the Development and Homeostasis of Alveolar Macrophages , 2017, Immunity.

[22]  H. Hammad,et al.  A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes , 2017, Nature Immunology.

[23]  A. Shilatifard,et al.  Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span , 2017, The Journal of experimental medicine.

[24]  S. Jonjić,et al.  A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family , 2017, Cell.

[25]  T. Tamura,et al.  Transcriptional control of monocyte and macrophage development. , 2017, International immunology.

[26]  Omar Sharif,et al.  First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment , 2017, Cell reports.

[27]  J. Koch,et al.  Clr-a: A Novel Immune-Related C-Type Lectin-like Molecule Exclusively Expressed by Mouse Gut Epithelium , 2017, The Journal of Immunology.

[28]  Jimin Gao,et al.  Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages , 2017, The Journal of Immunology.

[29]  A. Mucci,et al.  Lung surfactant metabolism: early in life, early in disease and target in cell therapy , 2016, Cell and Tissue Research.

[30]  Sagar,et al.  DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas , 2016, Cell.

[31]  Murugesan V. S. Rajaram,et al.  CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis , 2016, The Journal of Immunology.

[32]  B. Spiegelman,et al.  Cell biology of fat storage , 2016, Molecular biology of the cell.

[33]  Y. Saeys,et al.  Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages. , 2016, Immunity.

[34]  H. Sekhon,et al.  Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion , 2016, PLoS pathogens.

[35]  M. Jordana,et al.  TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity , 2016, PLoS pathogens.

[36]  W. Janssen,et al.  PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages , 2015 .

[37]  J. Coligan,et al.  CD300f associates with IL-4 receptor α and amplifies IL-4–induced immune cell responses , 2015, Proceedings of the National Academy of Sciences.

[38]  Peter Chen,et al.  Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection , 2015, Journal of Innate Immunity.

[39]  A. Makrigiannis,et al.  The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses. , 2015, Blood.

[40]  G. Velasco,et al.  Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia. , 2015, American journal of physiology. Cell physiology.

[41]  R. Chambers,et al.  Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production , 2015, American journal of physiology. Lung cellular and molecular physiology.

[42]  M. Hornef,et al.  Dedicated immunosensing of the mouse intestinal epithelium facilitated by a pair of genetically coupled lectin-like receptors , 2014, Mucosal Immunology.

[43]  A. Makrigiannis,et al.  The mouse NKR-P 1 B : Clr-b recognition system is a negative regulator of innate immune responses , 2015 .

[44]  M. Kurrer,et al.  Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages , 2014, Nature Immunology.

[45]  G. Randolph,et al.  Origin and functions of tissue macrophages. , 2014, Immunity.

[46]  Maxim N. Artyomov,et al.  Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation , 2014, Nature Immunology.

[47]  S. Tsuchida,et al.  Ly49 and C-type lectin receptors on dendritic cells regulate T-cell differentiation as co-stimulatory molecules , 2014 .

[48]  Alex K. Heer,et al.  Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection , 2014, PLoS pathogens.

[49]  J. Carlyle,et al.  Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition Systems , 2014, Front. Immunol..

[50]  S. Gross,et al.  Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites , 2014, The Journal of cell biology.

[51]  B. Yao,et al.  S phase cell percentage normalized BrdU incorporation rate, a new parameter for determining S arrest. , 2014, Biomedical and environmental sciences : BES.

[52]  A. Prince,et al.  Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity , 2014, Nature.

[53]  M. Ebina,et al.  Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function , 2013, The Journal of experimental medicine.

[54]  H. Perlman,et al.  Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. , 2013, American journal of respiratory cell and molecular biology.

[55]  G. Kelsoe,et al.  Identification of a Tissue-Specific, C/EBPβ-Dependent Pathway of Differentiation for Murine Peritoneal Macrophages , 2013, The Journal of Immunology.

[56]  Bernard Malissen,et al.  Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF , 2013, The Journal of experimental medicine.

[57]  F. Ginhoux,et al.  Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. , 2013, Immunity.

[58]  M. Ricote,et al.  Retinoid X receptors in macrophage biology , 2013, Trends in Endocrinology & Metabolism.

[59]  P. Thomas,et al.  Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections , 2013, The Journal of Immunology.

[60]  J. Garssen,et al.  Ligand Binding and Signaling of Dendritic Cell Immunoreceptor (DCIR) Is Modulated by the Glycosylation of the Carbohydrate Recognition Domain , 2013, PloS one.

[61]  J. Marvel,et al.  S1PR5 is pivotal for the homeostasis of patrolling monocytes , 2013, European journal of immunology.

[62]  F. Ginhoux,et al.  Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. , 2013, Immunity.

[63]  Justin G. Roy,et al.  Ly49Q Positively Regulates Type I IFN Production by Plasmacytoid Dendritic Cells in an Immunoreceptor Tyrosine–Based Inhibitory Motif–Dependent Manner , 2013, The Journal of Immunology.

[64]  A. Mildner,et al.  Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. , 2013, Immunity.

[65]  H. Sekhon,et al.  Mouse Nkrp1-Clr Gene Cluster Sequence and Expression Analyses Reveal Conservation of Tissue-Specific MHC-Independent Immunosurveillance , 2012, PloS one.

[66]  Johannes E. Schindelin,et al.  Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.

[67]  O. A. Aguilar,et al.  Poxvirus Infection-Associated Downregulation of C-Type Lectin-Related-b Prevents NK Cell Inhibition by NK Receptor Protein-1B , 2012, The Journal of Immunology.

[68]  Jing Ye,et al.  Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis , 2012, Protein & Cell.

[69]  S. Kersten,et al.  Re-evaluating lipotoxic triggers in skeletal muscle: relating intramyocellular lipid metabolism to insulin sensitivity. , 2012, Progress in lipid research.

[70]  R. Silverstein,et al.  Vav Protein Guanine Nucleotide Exchange Factor Regulates CD36 Protein-mediated Macrophage Foam Cell Formation via Calcium and Dynamin-dependent Processes* , 2011, The Journal of Biological Chemistry.

[71]  M. Inngjerdingen,et al.  Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse , 2011, Immunogenetics.

[72]  D. Chung,et al.  CD1d-Restricted IFN-γ–Secreting NKT Cells Promote Immune Complex-Induced Acute Lung Injury by Regulating Macrophage-Inflammatory Protein-1α Production and Activation of Macrophages and Dendritic Cells , 2011, The Journal of Immunology.

[73]  C. Casals,et al.  Recent advances in alveolar biology: Evolution and function of alveolar proteins , 2010, Respiratory Physiology & Neurobiology.

[74]  H. Yonekawa,et al.  The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking. , 2010, Immunity.

[75]  R. Silverstein,et al.  Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis. , 2010, Transactions of the American Clinical and Climatological Association.

[76]  andra Orgeiga,et al.  eview ecent advances in alveolar biology : Evolution and function of alveolar proteins , 2010 .

[77]  D. Fernig,et al.  N-Glycosylation Regulates Fibroblast Growth Factor Receptor/EGL-15 Activity in Caenorhabditis elegans in Vivo* , 2009, The Journal of Biological Chemistry.

[78]  W. Janssen,et al.  Lung environment determines unique phenotype of alveolar macrophages. , 2009, American journal of physiology. Lung cellular and molecular physiology.

[79]  A. Makrigiannis,et al.  Evolution of the Ly49 and Nkrp1 recognition systems. , 2008, Seminars in immunology.

[80]  T. Martin,et al.  Osteoclast Inhibitory Lectin, an Immune Cell Product That Is Required for Normal Bone Physiology in Vivo* , 2008, Journal of Biological Chemistry.

[81]  A. Barclay,et al.  A critical function for CD200 in lung immune homeostasis and the severity of influenza infection , 2008, Nature Immunology.

[82]  G. Downey,et al.  Rare lung diseases. II Pulmonary alveolar proteinosis , 2008 .

[83]  D. Metzger,et al.  Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection , 2008, Nature Medicine.

[84]  G. Downey,et al.  Rare lung disease II: pulmonary alveolar proteinosis. , 2008, Canadian respiratory journal.

[85]  C. Marsh,et al.  Alveolar macrophages lack CCR2 expression and do not migrate to CCL2 , 2007, Journal of Inflammation.

[86]  Xianlin Han,et al.  Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death Published, JLR Papers in Press, September 7, 2006. , 2006, Journal of Lipid Research.

[87]  A. Makrigiannis,et al.  Molecular and Genetic Basis for Strain-Dependent NK1.1 Alloreactivity of Mouse NK Cells1 , 2006, The Journal of Immunology.

[88]  J. Zúñiga-Pflücker,et al.  Functional Requirements for Signaling through the Stimulatory and Inhibitory Mouse NKR-P1 (CD161) NK Cell Receptors1 , 2005, The Journal of Immunology.

[89]  S. Gasser,et al.  Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[90]  P. Ince,et al.  Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection 1 , 2003, The Journal of Immunology.

[91]  A. Tall,et al.  Retinoic Acid Receptor-Mediated Induction of ABCA1 in Macrophages , 2003, Molecular and Cellular Biology.

[92]  Steffen Jung,et al.  Blood monocytes consist of two principal subsets with distinct migratory properties. , 2003, Immunity.

[93]  T. van der Poll,et al.  Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. , 2003, American journal of respiratory and critical care medicine.

[94]  N. Olson,et al.  Dendritic Cell-Associated Lectin-1: A Novel Dendritic Cell-Associated, C-Type Lectin-Like Molecule Enhances T Cell Secretion of IL-41 , 2002, The Journal of Immunology.

[95]  W. Mcgregor,et al.  Inhibition of DNA Replication and Induction of S Phase Cell Cycle Arrest by G-rich Oligonucleotides* , 2001, The Journal of Biological Chemistry.

[96]  J. Whitsett,et al.  GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. , 2001, Immunity.

[97]  E. Veldhuizen,et al.  Role of pulmonary surfactant components in surface film formation and dynamics. , 2000, Biochimica et biophysica acta.

[98]  D. Hansell,et al.  Pulmonary alveolar proteinosis: clinical aspects and current concepts on pathogenesis , 2000, Thorax.

[99]  L. Attisano,et al.  Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function. , 1999, Journal of immunology.

[100]  邦彦 小尾口 Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia , 1999 .

[101]  C. Epstein,et al.  Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[102]  Andrew C. Li,et al.  Differential Utilization of Ras Signaling Pathways by Macrophage Colony-Stimulating Factor (CSF) and Granulocyte-Macrophage CSF Receptors during Macrophage Differentiation , 1998, Molecular and Cellular Biology.

[103]  M. Baccarini,et al.  Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway , 1996, Molecular and cellular biology.

[104]  L. Teppo,et al.  Pulmonary alveolar proteinosis. , 1966, Annales chirurgiae et gynaecologiae Fenniae.