An efficient one‐pot solvent‐free synthesis of 2,3‐dihydroquinazoline‐4(1H)‐ones via Al/Al2O3 nanoparticles

An efficient one-pot, solvent-free method is reported for the synthesis of 2-phenyl-2,3-dihydroquinazoline-4(1H)-one as well as its o-Cl, o-OMe, m-Br, m-NO2, p-OH, p-NO2, p-CN, p-PhCH2O, p-Cl, p-F, p-Br, p-Me, and o,m-dichloro derivatives, using our “as-prepared” arc discharge fabricated Al/Al2O3 nanoparticles. Compared with our previous report and other known methods, this route gives higher yields with shorter reaction times, whereas its green catalyst appears recyclable at least four times-with minor decrease in its catalytic activity, under mild conditions. J. Heterocyclic Chem., (2010).

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