Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells

[1]  K. Pumiglia,et al.  Integrin alpha3beta1-dependent activation of FAK/Src regulates Rac1-mediated keratinocyte polarization on laminin-5. , 2007, The Journal of investigative dermatology.

[2]  K. Pumiglia,et al.  Integrin α3β1-Dependent Activation of FAK/Src Regulates Rac1-Mediated Keratinocyte Polarization on Laminin-5 , 2007 .

[3]  L. Otterbein,et al.  N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. , 2006, Journal of medicinal chemistry.

[4]  M. Planas-Silva,et al.  Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer. , 2006, Biochemical and biophysical research communications.

[5]  R. Nicholson,et al.  Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells , 2006, Breast Cancer Research and Treatment.

[6]  E. Avizienyte,et al.  Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. , 2005, Current opinion in cell biology.

[7]  E. Avizienyte,et al.  Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. , 2005, Cancer research.

[8]  Michael D Schaller,et al.  The interplay between Src and integrins in normal and tumor biology , 2004, Oncogene.

[9]  Wenjun Guo,et al.  Integrin signalling during tumour progression , 2004, Nature Reviews Molecular Cell Biology.

[10]  D. Schlaepfer,et al.  Control of motile and invasive cell phenotypes by focal adhesion kinase. , 2004, Biochimica et biophysica acta.

[11]  S. Scully,et al.  Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cells. , 2004, The Biochemical journal.

[12]  M. Schaller,et al.  FAK regulates biological processes important for the pathogenesis of cancer , 2003, Cancer and Metastasis Reviews.

[13]  G. Gallick,et al.  Src family kinases in tumor progression and metastasis , 2003, Cancer and Metastasis Reviews.

[14]  S. K. Shore,et al.  SRC in human carcinogenesis. , 2003, Frontiers in bioscience : a journal and virtual library.

[15]  Takashi Matsumoto,et al.  Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis. , 2003, Cancer research.

[16]  H. Yoshiji,et al.  pp60c-src activation in lung adenocarcinoma. , 2003, European journal of cancer.

[17]  A. Sahin,et al.  Heregulin and HER2 signaling selectively activates c‐Src phosphorylation at tyrosine 215 , 2003, FEBS letters.

[18]  R. Nicholson,et al.  Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. , 2003, Endocrinology.

[19]  E. Avizienyte,et al.  Elevated c-Src is linked to altered cell–matrix adhesion rather than proliferation in KM12C human colorectal cancer cells , 2002, British Journal of Cancer.

[20]  H. Frierson,et al.  Expression of focal adhesion kinase in normal and pathologic human prostate tissues , 2002, The Prostate.

[21]  M. Frame,et al.  Src in cancer: deregulation and consequences for cell behaviour. , 2002, Biochimica et biophysica acta.

[22]  T. Yeatman,et al.  Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells. , 2002, Cancer research.

[23]  W. Marston,et al.  Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia. , 2001, Journal of vascular surgery.

[24]  M. Schaller.  Biochemical signals and biological responses elicited by the focal adhesion kinase. , 2001, Biochimica et biophysica acta.

[25]  J. Parsons,et al.  Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells , 2001, Oncogene.

[26]  Li Zhang,et al.  Ligand Binding to Integrins* , 2000, The Journal of Biological Chemistry.

[27]  E. Parkinson,et al.  Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells , 1999, Oncogene.

[28]  D. Schlaepfer,et al.  Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. , 1999, Journal of cell science.

[29]  R. Bast,et al.  Decreased Src tyrosine kinase activity inhibits malignant human ovarian cancer tumor growth in a nude mouse model. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[30]  G. Rijksen,et al.  Overexpression of c-Src enhances cell-matrix adhesion and cell migration in PDGF-stimulated NIH3T3 fibroblasts. , 1999, Experimental cell research.

[31]  H. Varmus,et al.  Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. , 1997, Genes & development.

[32]  S. Hanks,et al.  Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. , 1996, Biochemical and biophysical research communications.

[33]  T. Hunter,et al.  Signal transduction from the extracellular matrix--a role for the focal adhesion protein-tyrosine kinase FAK. , 1996, Cell structure and function.

[34]  W. Cance,et al.  Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. , 1995, Cancer research.

[35]  H. Varmus,et al.  c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. , 1995, Genes & development.

[36]  S. Hanks,et al.  Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases , 1995, Molecular and cellular biology.

[37]  S. J. Taylor,et al.  Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. , 1994, Molecular biology of the cell.

[38]  J. Parsons,et al.  Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src , 1994, Molecular and cellular biology.

[39]  J. Parsons,et al.  Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK , 1994, Molecular and cellular biology.

[40]  J. Parsons,et al.  Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene , 1989, Molecular and cellular biology.