P045. The MelGene database: A field synopsis of genetic association studies in cutaneous melanoma

Results: Overall, 26 different MC1R gene polymorphisms were detected, two of which were novel (V165I and V188I). MC1R gene polymorphisms were present in 76.5% (153/200) of melanoma patients compared to 58.0% (116/200) of control persons, yielding an odds ratio (OR) of 2.36 [95% confidence interval (CI): 1.56– 3.63, P < 0.001] for melanoma in MC1R gene polymorphisms carriers. A gene dosage effect was noted, with enhanced melanoma risk being observed in persons carrying multiple polymorphisms (OR for one polymorphism: 1.98; 95% CI: 1.26–3.11, P = 0.003, and OR for Z 2 polymorphisms: 3.98; 95% CI: 2.14–7.38, P < 0.001). In stratified analysis, melanoma risk was stronger in or limited to persons with more protective phenotypes, such as those who had dark hair color (OR = 4.48; 95% CI: 1.84–10.91, P < 0.001), skin photo-type III or IV (OR = 3.56; 95% CI: 1.60–7.93, P = 0.001) or who did not freckle (OR = 3.31; 95% CI: 1.54–7.12, P = 0.002).