Lectin from Dioclea violacea induces autophagy in U87 glioma cells.

[1]  Jinhua Zhang,et al.  mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy , 2019, International journal of molecular sciences.

[2]  K. Nascimento,et al.  ConA-Like Lectins: High Similarity Proteins as Models to Study Structure/Biological Activities Relationships , 2018, International journal of molecular sciences.

[3]  D. Montell,et al.  Unconventional Ways to Live and Die: Cell Death and Survival in Development, Homeostasis, and Disease. , 2018, Annual review of cell and developmental biology.

[4]  E. Baehrecke,et al.  Life, death and autophagy , 2018, Nature Cell Biology.

[5]  D. Rieger,et al.  Anti-glioma properties of DVL, a lectin purified from Dioclea violacea. , 2018, International journal of biological macromolecules.

[6]  K. Nascimento,et al.  Crystal structure of DlyL, a mannose-specific lectin from Dioclea lasiophylla Mart. Ex Benth seeds that display cytotoxic effects against C6 glioma cells. , 2018, International journal of biological macromolecules.

[7]  I. Dikic,et al.  Mechanism and medical implications of mammalian autophagy , 2018, Nature reviews. Molecular cell biology.

[8]  K. Cooper Till Death Do Us Part: The Marriage of Autophagy and Apoptosis , 2018, Oxidative medicine and cellular longevity.

[9]  A. Pause,et al.  mTOR Pathways in Cancer and Autophagy , 2018, Cancers.

[10]  Miaoqing Zhao,et al.  Autophagy flux inhibition, G2/M cell cycle arrest and apoptosis induction by ubenimex in glioma cell lines , 2017, Oncotarget.

[11]  S. Abediankenari,et al.  Acrylamide induces immunotoxicity through reactive oxygen species production and caspase-dependent apoptosis in mice splenocytes via the mitochondria-dependent signaling pathways. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[12]  J. Pearson,et al.  Targeting cellular pathways in glioblastoma multiforme , 2017, Signal Transduction and Targeted Therapy.

[13]  J. Tiralongo,et al.  Cancer stem cell marker glycosylation: Nature, function and significance , 2017, Glycoconjugate Journal.

[14]  K. Raghu,et al.  Morus alba Leaf Lectin (MLL) Sensitizes MCF-7 Cells to Anoikis by Inhibiting Fibronectin Mediated Integrin-FAK Signaling through Ras and Activation of P38 MAPK , 2017, Front. Pharmacol..

[15]  R. Zhan,et al.  Chloroquine, an autophagy inhibitor, potentiates the radiosensitivity of glioma initiating cells by inhibiting autophagy and activating apoptosis , 2016, BMC Neurology.

[16]  Kamau Fahie,et al.  Molecular Functions of Glycoconjugates in Autophagy. , 2016, Journal of molecular biology.

[17]  G. Reifenberger,et al.  The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary , 2016, Acta Neuropathologica.

[18]  S. Sideris,et al.  Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR , 2016, ACS medicinal chemistry letters.

[19]  C. G. Suresh,et al.  Two Chitotriose-Specific Lectins Show Anti-Angiogenesis, Induces Caspase-9-Mediated Apoptosis and Early Arrest of Pancreatic Tumor Cell Cycle , 2016, PloS one.

[20]  M. L. Macedo,et al.  Entomotoxic properties of Dioclea violacea lectin and its effects on digestive enzymes of Anagasta kuehniella (Lepidoptera). , 2015, Journal of insect physiology.

[21]  K. Watabe,et al.  Mechanisms regulating glioma invasion. , 2015, Cancer letters.

[22]  R. Cetin-Atalay,et al.  The PI3K/AKT/mTOR interactive pathway. , 2015, Molecular bioSystems.

[23]  L. Ouyang,et al.  Plant lectins, from ancient sugar‐binding proteins to emerging anti‐cancer drugs in apoptosis and autophagy , 2015, Cell proliferation.

[24]  E. Baehrecke,et al.  Autophagy, cell death, and cancer , 2015, Molecular & cellular oncology.

[25]  B. Annabi,et al.  Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells. , 2014, Cellular signalling.

[26]  T. K. Maiti,et al.  Role of PI3K/Akt/mTOR and MEK/ERK pathway in Concanavalin A induced autophagy in HeLa cells. , 2014, Chemico-biological interactions.

[27]  Hailiang Wang,et al.  Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells , 2013, Molecular and Cellular Biochemistry.

[28]  B. Manning,et al.  Signal integration by mTORC1 coordinates nutrient input with biosynthetic output , 2013, Nature Cell Biology.

[29]  G. Rabinovich,et al.  Glycobiology of cell death: when glycans and lectins govern cell fate , 2013, Cell Death and Differentiation.

[30]  G. A. Bezerra,et al.  Crystal structure of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea rostrata lectin. , 2013, The international journal of biochemistry & cell biology.

[31]  Roman Jaksik,et al.  Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer , 2013, Archivum Immunologiae et Therapiae Experimentalis.

[32]  B. Cavada,et al.  Neutrophil-infiltrated paw edema induced by mannose-binding Dioclea violacea lectin , 2013, Pharmacological reports : PR.

[33]  J. Barnholtz-Sloan,et al.  CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. , 2012, Neuro-oncology.

[34]  B. Annabi,et al.  Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells. , 2012, Glycobiology.

[35]  Li-hua Shang,et al.  Luffa echinata Roxb. Induces Human Colon Cancer Cell (HT-29) Death by Triggering the Mitochondrial Apoptosis Pathway , 2012, Molecules.

[36]  E. White Role of autophagy in cancer , 2012 .

[37]  J. Blenis,et al.  The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. , 2011, Trends in biochemical sciences.

[38]  Y. Ikeda,et al.  Clinicopathologic Application of Lectin Histochemistry: Bisecting GlcNAc in Glioblastoma , 2010, Applied immunohistochemistry & molecular morphology : AIMM.

[39]  J. Bao,et al.  Concanavalin A, from an old protein to novel candidate anti-neoplastic drug. , 2010, Current molecular pharmacology.

[40]  D. Rubinsztein,et al.  Regulation of mammalian autophagy in physiology and pathophysiology. , 2010, Physiological reviews.

[41]  J. Bao,et al.  Induction of apoptosis by Concanavalin A and its molecular mechanisms in cancer cells , 2009, Autophagy.

[42]  J. Bao,et al.  Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells. , 2009, Archives of biochemistry and biophysics.

[43]  G. Riggins,et al.  Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells , 2009, Molecular Cancer Therapeutics.

[44]  C. Tasca,et al.  Thyroid hormone increases astrocytic glutamate uptake and protects astrocytes and neurons against glutamate toxicity , 2008, Journal of neuroscience research.

[45]  Yee‐Shin Lin,et al.  Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model , 2007, Hepatology.

[46]  C. Liang,et al.  In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro , 2007, Nature Protocols.

[47]  J. Rich,et al.  New treatment strategies for malignant gliomas , 2006, Expert review of anticancer therapy.

[48]  Anupama Munshi,et al.  Clonogenic cell survival assay. , 2005, Methods in molecular medicine.

[49]  M. Köhn,et al.  Functional Evaluation of Carbohydrate‐Centred Glycoclusters by Enzyme‐Linked Lectin Assay: Ligands for Concanavalin A , 2004, Chembiochem : a European journal of chemical biology.

[50]  B. Cavada,et al.  Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins. , 2001, Current protein & peptide science.

[51]  Takeshi Noda,et al.  LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.

[52]  B. Cavada,et al.  Diocleinae Lectins Are a Group of Proteins with Conserved Binding Sites for the Core Trimannoside of Asparagine-linked Oligosaccharides and Differential Specificities for Complex Carbohydrates* , 1998, The Journal of Biological Chemistry.

[53]  B. Cavada,et al.  Anti-inflammatory effect of glucose—mannose binding lectins isolated from Brazilian beans , 1997, Mediators of inflammation.

[54]  C. McCulloch,et al.  Concanavalin A induced apoptosis in fibroblasts: The role of cell surface carbohydrates in lectin mediated cytotoxicity , 1995, Journal of cellular physiology.

[55]  T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[56]  R. Wolstencroft,et al.  Concanavalin A as an inducer of human lymphocyte mitogenic factor. , 1972, Nature: New biology.

[57]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[58]  K. Nascimento,et al.  ConBr, the Lectin from Canavalia brasiliensis Mart. Seeds: Forty Years of Research. , 2019, Current protein & peptide science.

[59]  Jill S. Barnholtz-Sloan,et al.  CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012 , 2015, Neuro-oncology.

[60]  J. Bao,et al.  Plant lectins: potential antineoplastic drugs from bench to clinic. , 2010, Cancer letters.

[61]  Jiahuai Han,et al.  Activation and signaling of the p38 MAP kinase pathway , 2005, Cell Research.

[62]  H. Oh,et al.  Roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in apoptosis of human monoblastic leukemia U937 cells by lectin-II isolated from Korean mistletoe. , 2001, In vitro & molecular toxicology.

[63]  B. Cavada,et al.  Isolation and partial characterization of a lectin from seeds of Dioclea violacea , 1996 .