A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors

Paul A Clemons | Andrea Califano | Daniel Kaemmerer | Shereen Ezzat | Ülo Langel | Arul M Chinnaiyan | Kay Washington | Lisa Bodei | Bertram Wiedenmann | Stuart Schreiber | Charles Karan | Mariano J Alvarez | Mark Kidd | Irvin Modlin | Andrea Frilling | Adina Grunn | Diane Reidy-Lagunes | Beatrice S Knudsen | Andrew L Kung | Roberto Bergamaschi | P. Clemons | A. Chinnaiyan | S. Schreiber | D. Metz | H. Kim | K. Washington | Laura H. Tang | A. Califano | A. Grunn | A. Rustgi | A. Sepulveda | S. Ezzat | M. Alvarez | R. Bergamaschi | I. Modlin | V. Livolsi | G. Rieckhof | A. Kung | B. Wiedenmann | S. Serra | Kyoung-Mee Kim | B. Knudsen | Xiaopu Yuan | Afshin Ghavami | Jeeyun Lee | L. Kunju | Ü. Langel | D. Jaeger | P. Subramaniam | Ronald B. Realubit | Charles Karan | M. Kim | H. Remotti | M. Kidd | J. Milsom | Jakob Regberg | C. Shi | F. D. Dela Cruz | Daniel Diolaiti | R. Roses | L. Bodei | Chanjuan Shi | Jeeyun Lee | Mahalaxmi Aburi | E. Komissarova | Elizabeth Hagan | D. Dhall | Douglas A. Fraker | D. Kaemmerer | Zhong Li | Hai Li | R. Pfragner | Allison R. Rainey | M. Barberis | Tony Detre | A. Frilling | M. Hommann | E. Leahy | Y. Park | D. Reidy-Lagunes | Massimo Barberis | Helen Remotti | David C Metz | Dirk Jaeger | Robert Roses | Laura H Tang | Deepti Dhall | Xiaopu Yuan | Jeffrey W Milsom | Lakshmi P Kunju | Hai Li | Mahalaxmi Aburi | Daniel Diolaiti | Antonia R Sepulveda | Elena V Komissarova | Afshin Ghavami | Filemon S Dela Cruz | Roswitha Pfragner | Gabrielle Rieckhof | Stefano Serra | Prem S Subramaniam | Elizabeth A Hagan | Douglas A Fraker | Kyoung M Kim | Hee C Kim | Zhong Li | Virginia LiVolsi | Allison R Rainey | Ronald B Realubit | Jakob Regberg | Anil Rustgi | Tony Detre | Merten Hommann | Michelle K Kim | Emer Leahy | Young S Park | Elizabeth A. Hagan | D. Fraker | D. Reidy‐Lagunes

[1]  R. Young,et al.  Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. , 2018, Cancer discovery.

[2]  Mariano J. Alvarez,et al.  An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis. , 2017, Cell reports.

[3]  Mariano J. Alvarez,et al.  The recurrent architecture of tumour initiation, progression and drug sensitivity , 2016, Nature Reviews Cancer.

[4]  I. Tannock,et al.  Limits to Personalized Cancer Medicine. , 2016, The New England journal of medicine.

[5]  S. Severi,et al.  A Delphic consensus assessment: imaging and biomarkers in gastroenteropancreatic neuroendocrine tumor disease management , 2016, Endocrine connections.

[6]  P. Engstrom,et al.  Molecular profiling of neuroendocrine malignancies to identify prognostic and therapeutic markers: a Fox Chase Cancer Center Pilot Study , 2016, British Journal of Cancer.

[7]  Mariano J. Alvarez,et al.  Network-based inference of protein activity helps functionalize the genetic landscape of cancer , 2016, Nature Genetics.

[8]  Andrea Califano,et al.  Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. , 2016, Cancer research.

[9]  Andrea Califano,et al.  Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models. , 2015, Cell reports.

[10]  A. Califano,et al.  Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers. , 2015, Genes & development.

[11]  S. Hensley,et al.  Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift during the 2014-2015 Influenza Season. , 2015, Cell reports.

[12]  S. Friend,et al.  Impact of centralization on aCGH-based genomic profiles for precision medicine in oncology. , 2015, Annals of Oncology.

[13]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[14]  W. Hahn,et al.  Prospective enterprise-level molecular genotyping of a cohort of cancer patients. , 2014, The Journal of molecular diagnostics : JMD.

[15]  Samantha A. Morris,et al.  CellNet: Network Biology Applied to Stem Cell Engineering , 2014, Cell.

[16]  Mariano J. Alvarez,et al.  Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. , 2014, Cancer cell.

[17]  Andrea Califano,et al.  Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. , 2013, Cancer cell.

[18]  Trevor J Pugh,et al.  Somatic mutation of CDKN1B in small intestine neuroendocrine tumors , 2013, Nature Genetics.

[19]  Joshua C. Gilbert,et al.  An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules , 2013, Cell.

[20]  Michael B Atkins,et al.  Which drug, and when, for patients with BRAF-mutant melanoma? , 2013, The Lancet. Oncology.

[21]  R. Salazar,et al.  Gastroenteropancreatic neuroendocrine tumors: diagnosis and treatment , 2013, Annals of gastroenterology.

[22]  Adam A. Margolin,et al.  The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.

[23]  J. Rosai.  The origin of neuroendocrine tumors and the neural crest saga , 2011, Modern Pathology.

[24]  Michael A. Choti,et al.  DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors , 2011, Science.

[25]  C. I. Smith,et al.  PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation , 2011, Nucleic acids research.

[26]  Benito Munoz,et al.  Towards patient-based cancer therapeutics , 2010, Nature Biotechnology.

[27]  Mariano J. Alvarez,et al.  A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers , 2010, Molecular systems biology.

[28]  Wei Keat Lim,et al.  The transcriptional network for mesenchymal transformation of brain tumors , 2009, Nature.

[29]  Andrea Califano,et al.  Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells. , 2008, Blood.

[30]  B. A. Hocevar,et al.  Progression and treatment of HER2-positive breast cancer , 2010, Cancer Chemotherapy and Pharmacology.

[31]  R. Dalla‐Favera,et al.  Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma , 2009, Nature.

[32]  E. Ingolič,et al.  Establishment and characterization of three novel cell lines - P-STS, L-STS, H-STS - derived from a human metastatic midgut carcinoid. , 2009, Anticancer research.

[33]  Ji Luo,et al.  Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction , 2009, Cell.

[34]  Cole Trapnell,et al.  Ultrafast and memory-efficient alignment of short DNA sequences to the human genome , 2009, Genome Biology.

[35]  H. Nagawa,et al.  Prognosis and risk factors of metastasis in colorectal carcinoids: results of a nationwide registry over 15 years , 2007, Gut.

[36]  J. Collins,et al.  Large-Scale Mapping and Validation of Escherichia coli Transcriptional Regulation from a Compendium of Expression Profiles , 2007, PLoS biology.

[37]  Chris Wiggins,et al.  ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context , 2004, BMC Bioinformatics.

[38]  B. Eriksson,et al.  Endocrine tumours of the pancreas. , 2005, Best practice & research. Clinical gastroenterology.

[39]  Adam A. Margolin,et al.  Reverse engineering of regulatory networks in human B cells , 2005, Nature Genetics.

[40]  Jean YH Yang,et al.  Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.

[41]  I. Weinstein.  Addiction to Oncogenes--the Achilles Heal of Cancer , 2002, Science.

[42]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[43]  E. Ingolič,et al.  Establishment of a continuous cell line from a human carcinoid of the small intestine (KRJ-I). , 1996, International journal of oncology.