Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseases.

[1]  T. Long,et al.  Citri Reticulatae Semen extract promotes healthy aging and neuroprotection via autophagy induction in Caenorhabditis elegans. , 2022, The journals of gerontology. Series A, Biological sciences and medical sciences.

[2]  Jingchun Zhou,et al.  Holistic quality evaluation of Hibisci Mutabilis Folium by integrating UPLC-QTOF-MS/MS chemical profiling and UPLC-TQ-MS/MS quantification approaches. , 2022, Journal of pharmaceutical and biomedical analysis.

[3]  T. Long,et al.  Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in C. elegans and Cellular Models of Parkinson's Disease , 2022, Oxidative medicine and cellular longevity.

[4]  T. Long,et al.  Chlorogenic acid delays the progression of Parkinson's disease via autophagy induction in Caenorhabditis elegans , 2021, Nutritional neuroscience.

[5]  J. Quiles,et al.  Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer's beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans. , 2021, Food chemistry.

[6]  Cai-xia Zang,et al.  Gardenia jasminoides J.Ellis extract GJ-4 alleviated cognitive deficits of APP/PS1 transgenic mice. , 2021, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[7]  B. Law,et al.  High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS , 2021, Acta pharmaceutica Sinica. B.

[8]  Dongfeng Chen,et al.  Antioxidant product analysis of Folium Hibisci Mutabilis , 2021, Journal of Saudi Chemical Society.

[9]  Junxia Xie,et al.  Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson’s Disease , 2021, Frontiers in Pharmacology.

[10]  Regina Lamendella,et al.  Effects of FUdR on gene expression in the C. elegans bacterial diet OP50 , 2021, BMC Research Notes.

[11]  V. Wong,et al.  Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson’s disease , 2021, Signal Transduction and Targeted Therapy.

[12]  B. Law,et al.  Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases , 2020, Ageing Research Reviews.

[13]  H. Yi,et al.  N‐butanol extract of Hedyotis diffusa protects transgenic Caenorhabditis elegans from Aβ‐induced toxicity , 2020, Phytotherapy research : PTR.

[14]  Q. Mei,et al.  Lychee seed polyphenol protects the blood–brain barrier through inhibiting Aβ(25–35)‐induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1‐mediated autophagy in bEnd.3 cells and APP/PS1 mice , 2020, Phytotherapy research : PTR.

[15]  K. Blomgren,et al.  Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases. , 2020, Journal of neurochemistry.

[16]  D. Rubinsztein,et al.  Autophagy induction as a therapeutic strategy for neurodegenerative diseases. , 2019, Journal of molecular biology.

[17]  A. Sahebkar,et al.  Neuroprotective effects of curcumin through autophagy modulation , 2019, IUBMB life.

[18]  Omid Bavi,et al.  Recent advances in the design and applications of amyloid-β peptide aggregation inhibitors for Alzheimer’s disease therapy , 2019, Biophysical Reviews.

[19]  M. Ashrafizadeh,et al.  Autophagy as a molecular target of quercetin underlying its protective effects in human diseases , 2019, Archives of physiology and biochemistry.

[20]  Komal Panchal,et al.  Mitochondrial dynamics, a key executioner in neurodegenerative diseases. , 2019, Mitochondrion.

[21]  Wei-Jen Tang,et al.  Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy , 2019, Nature Communications.

[22]  Zhizhou Zhang,et al.  Age-dependent effects of floxuridine (FUdR) on senescent pathology and mortality in the nematode Caenorhabditis elegans. , 2019, Biochemical and biophysical research communications.

[23]  Biswadeep Das,et al.  Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies , 2019, Life sciences.

[24]  D. Holtzman,et al.  Intercellular Spread of Protein Aggregates in Neurodegenerative Disease. , 2018, Annual review of cell and developmental biology.

[25]  C. Soto,et al.  Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases , 2018, Nature Neuroscience.

[26]  R. Legouis,et al.  Approaches for Studying Autophagy in Caenorhabditis elegans , 2017, Cells.

[27]  Kee-Hong Kim,et al.  Piceatannol extends the lifespan of Caenorhabditis elegans via DAF‐16 , 2017, BioFactors.

[28]  S. Zou,et al.  Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans Model of Alzheimer's Disease. , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[29]  L. Ye,et al.  p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation , 2016, Cellular & Molecular Biology Letters.

[30]  Jeong-Hoon Hahm,et al.  C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation , 2015, Nature Communications.

[31]  D. Wan,et al.  Determination of rutin and isoquercetin contents in Hibisci mutabilis Folium in different collection periods by HPLC. , 2015, Journal of chromatographic science.

[32]  Junying Yuan,et al.  Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach , 2015, Molecules and cells.

[33]  Rui Liu,et al.  Network Pharmacology Bridges Traditional Application and Modern Development of Traditional Chinese Medicine , 2015 .

[34]  M. Hansen,et al.  Guidelines for monitoring autophagy in Caenorhabditis elegans , 2015, Autophagy.

[35]  Nektarios Tavernarakis,et al.  Autophagy in the physiology and pathology of the central nervous system , 2014, Cell Death and Differentiation.

[36]  S. Lipton,et al.  Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease , 2014, Molecular Neurodegeneration.

[37]  G. Silverman,et al.  C. elegans in high-throughput drug discovery. , 2014, Advanced drug delivery reviews.

[38]  A. Antebi,et al.  Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life , 2014, Cell.

[39]  D. Kim,et al.  4-Hydroxybenzoic acid-mediated lifespan extension in Caenorhabditis elegans , 2014 .

[40]  M. Sandri,et al.  Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies , 2013, Journal of Cell Science.

[41]  Miriam Rodriguez,et al.  Worms under stress: C. elegans stress response and its relevance to complex human disease and aging. , 2013, Trends in genetics : TIG.

[42]  Wei-dong Hu,et al.  Application and interpretation of current autophagy inhibitors and activators , 2013, Acta Pharmacologica Sinica.

[43]  A. Lang.  Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future , 2010, Nature Medicine.

[44]  D. Howells,et al.  Can Animal Models of Disease Reliably Inform Human Studies? , 2010, PLoS medicine.

[45]  E. Masliah,et al.  Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases , 2009, The Journal of Neuroscience.

[46]  A. A. Farooqui,et al.  Aging: An important factor for the pathogenesis of neurodegenerative diseases , 2009, Mechanisms of Ageing and Development.

[47]  Brian Spencer,et al.  The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. , 2008, The Journal of clinical investigation.

[48]  Nihal Ahmad,et al.  Dose translation from animal to human studies revisited , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  C. Ross,et al.  Protein aggregation and neurodegenerative disease , 2004, Nature Medicine.

[50]  Niaz Ahmed,et al.  Neuroprotection in Cerebral Ischaemia: Facts and Fancies – The Need for New Approaches , 2003, Cerebrovascular Diseases.

[51]  Jesper Givskov Sørensen,et al.  The evolutionary and ecological role of heat shock proteins , 2003 .

[52]  Stuart K. Kim,et al.  Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer’s disease model , 2003, Neurobiology of Aging.

[53]  H. T. Chan,et al.  A Review on the Phytochemistry and Pharmacology of two Hibiscus Species with Spectacular Flower Colour Change : H . tiliaceus and H . mutabilis , 2016 .

[54]  Alain Bousquet-Mélou,et al.  Species differences in pharmacokinetics and pharmacodynamics. , 2010, Handbook of experimental pharmacology.

[55]  Claudio Soto,et al.  Unfolding the role of protein misfolding in neurodegenerative diseases , 2003, Nature Reviews Neuroscience.