论文信息 - Immunofluorescence of epithelial skin tumors. I. Patterns of intercellular substance

Immunofluorescence of epithelial skin tumors. I. Patterns of intercellular substance

Epidermal tumors were studied for production of intercellular substance (ICS) present in normal epidermis. Antibody to ICS found in pemphigus serum was used and detected by immunofluorescent technique. ICS was absent in squamous cell carcinoma, and its absence was related to degree of neoplasia. Individual cell keratinization was related to ICS. Basal cell carcinomas had no ICS, similar to sweat gland tumors. Seborrheic keratosis and keratoacanthoma produced normal amounts of ICS. It appears possible to classify tumors by this technique and probably relate intercellular substance to tumor behavior.

R. Winkelmann | R. Jordon | J. de Moragas

[1] E. Beutner,et al. The immunopathology of pemphigus and bullous pemphigoid. , 1989, The Journal of investigative dermatology.

[2] E. Beutner,et al. The Immunopathology of Pemphigus and Bullous Pemphigoid**From the Department of Microbiology, SUNY at Buffalo School of Medicine, Buffalo, New York, Mayo Graduate School of Medicine, Rochester, Minn., and the Department of Dermatology, Warsaw Medical School, Warsaw, Poland. , 1968 .

[3] E. Beutner,et al. Quantitative studies of immunofluorescent staining. Relationships of characteristics of unabsorbed antihuman IgG conjugates to their specific and non-specific staining properties in an indirect test for antinuclear factors. , 1968, Bulletin of the World Health Organization.

[4] E. Holborow,et al. Quantitative studies of immunofluorescent staining. I. Analyses of mixed immunofluorescence. , 1967, Immunology.

[5] J. D. Marshall,et al. Superiority of Fluorescein Isothiocyanate (Riggs) for Fluorescent-Antibody Technic with a Modification of its Application , 1958, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.