A Markov Chain Channel Model for Active Transport Molecular Communication

In molecular communication, small particles such as molecules are used to convey information. These particles are released by a transmitter into a fluidic environment, where they propagate freely (e.g. through diffusion) or through externals means (e.g. different types of active transport) until they arrive at the receiver. Although there are a number of different mathematical models for the diffusion-based molecular communication, active transport molecular communication (ATMC) lacks the necessary theoretical framework. Previous works had to rely almost entirely on full Monte Carlo simulations of these systems. However, full simulations can be time consuming because of the computational complexities involved. In this paper, a Markov channel model has been presented, which could be used to reduce the amount of simulations necessary for studying ATMC without sacrificing accuracy. Moreover, a mathematical formula for calculating the transition probabilities in the Markov chain model is derived to complete our analytical framework. Comparing our proposed models with full simulations, it is shown that these models can be used to calculate parameters such channel capacity accurately in a timely manner.

[1]  N. Farsad,et al.  Modelling and design of polygon-shaped kinesin substrates for molecular communication , 2012, 2012 12th IEEE International Conference on Nanotechnology (IEEE-NANO).

[2]  Ian F. Akyildiz,et al.  Bacteria-based communication in nanonetworks , 2010, Nano Commun. Networks.

[3]  H. T. Mouftah,et al.  On the characterization of binary concentration-encoded molecular communication in nanonetworks , 2010, Nano Commun. Networks.

[4]  Nariman Farsad,et al.  A simple mathematical model for information rate of active transport molecular communication , 2011, 2011 IEEE Conference on Computer Communications Workshops (INFOCOM WKSHPS).

[5]  Takahiro Nitta,et al.  In silico design and testing of guiding tracks for molecular shuttles powered by kinesin motors. , 2010, Lab on a chip.

[6]  Geeta M Patel,et al.  Nanorobot: A versatile tool in nanomedicine , 2006, Journal of drug targeting.

[7]  Cees Dekker,et al.  Motor Proteins at Work for Nanotechnology , 2007, Science.

[8]  Kazuhiro Oiwa,et al.  Molecular Communication: Modeling Noise Effects on Information Rate , 2009, IEEE Transactions on NanoBioscience.

[9]  Aristides A. G. Requicha Nanorobots, NEMS, and nanoassembly , 2003 .

[10]  Kristen L. Helton,et al.  Microfluidic Overview of Global Health Issues Microfluidic Diagnostic Technologies for Global Public Health , 2006 .

[11]  Andrew W. Eckford Timing Information Rates for Active Transport Molecular Communication , 2009, NanoNet.

[12]  Thomas M. Cover,et al.  Elements of Information Theory , 2005 .

[13]  N. Farsad,et al.  On-Chip Molecular Communication: Analysis and Design , 2012, IEEE Transactions on NanoBioscience.

[14]  S. Takeuchi,et al.  Biomolecular-motor-based nano- or microscale particle translocations on DNA microarrays. , 2009, Nano letters.

[15]  Ian F. Akyildiz,et al.  Nanonetworks: A new communication paradigm , 2008, Comput. Networks.

[16]  Thomas M. Cover,et al.  Elements of information theory (2. ed.) , 2006 .

[17]  Massimiliano Pierobon,et al.  Capacity of a Diffusion-Based Molecular Communication System With Channel Memory and Molecular Noise , 2013, IEEE Transactions on Information Theory.

[18]  Suguru Arimoto,et al.  An algorithm for computing the capacity of arbitrary discrete memoryless channels , 1972, IEEE Trans. Inf. Theory.

[19]  Chan-Byoung Chae,et al.  Novel modulation techniques using isomers as messenger molecules for molecular communication via diffusion , 2012, 2012 IEEE International Conference on Communications (ICC).

[20]  N. Farsad,et al.  Microchannel molecular communication with nanoscale carriers: Brownian motion versus active transport , 2010, 10th IEEE International Conference on Nanotechnology.

[21]  Andrew W. Eckford,et al.  Nanoscale Communication with Brownian Motion , 2007, 2007 41st Annual Conference on Information Sciences and Systems.

[22]  Massimiliano Pierobon,et al.  Diffusion-Based Noise Analysis for Molecular Communication in Nanonetworks , 2011, IEEE Transactions on Signal Processing.

[23]  A. Hudspeth,et al.  Movement of microtubules by single kinesin molecules , 1989, Nature.

[24]  Özgür B. Akan,et al.  An information theoretical approach for molecular communication , 2007, 2007 2nd Bio-Inspired Models of Network, Information and Computing Systems.

[25]  Satoshi Hiyama,et al.  Molecular communication: Harnessing biochemical materials to engineer biomimetic communication systems , 2010, Nano Commun. Networks.

[26]  A. Vasilakos,et al.  Molecular Communication and Networking: Opportunities and Challenges , 2012, IEEE Transactions on NanoBioscience.

[27]  Özgür B. Akan,et al.  Deterministic capacity of information flow in molecular nanonetworks , 2010, Nano Commun. Networks.

[28]  Andrew W. Eckford,et al.  A mathematical channel optimization formula for active transport molecular communication , 2012, 2012 IEEE International Conference on Communications (ICC).

[29]  Miqin Zhang,et al.  Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. , 2010, Advanced drug delivery reviews.

[30]  Daniele Miorandi A stochastic model for molecular communications , 2011, Nano Commun. Networks.

[31]  K. Jensen,et al.  Nanotube radio. , 2007, Nano letters.

[32]  S. Takeuchi,et al.  Biomolecular-motor-based autonomous delivery of lipid vesicles as nano- or microscale reactors on a chip. , 2010, Lab on a chip.

[33]  Massimiliano Pierobon,et al.  Noise Analysis in Ligand-Binding Reception for Molecular Communication in Nanonetworks , 2011, IEEE Transactions on Signal Processing.

[34]  Massimiliano Pierobon,et al.  Information capacity of diffusion-based molecular communication in nanonetworks , 2011, 2011 Proceedings IEEE INFOCOM.

[35]  Andrew W. Eckford,et al.  Channel Design and Optimization of Active Transport Molecular Communication , 2011, BIONETICS.

[36]  Jian-Qin Liu,et al.  Design and Analysis of Molecular Relay Channels: An Information Theoretic Approach , 2010, IEEE Transactions on NanoBioscience.

[37]  Andrew W. Eckford,et al.  Information Rates of Active Propagation in Microchannel Molecular Communication , 2010, BIONETICS.

[38]  Richard E. Blahut,et al.  Computation of channel capacity and rate-distortion functions , 1972, IEEE Trans. Inf. Theory.

[39]  Andrew W. Eckford,et al.  Quick system design of vesicle-based active transport molecular communication by using a simple transport model , 2011, Nano Commun. Networks.

[40]  Massimiliano Pierobon,et al.  A physical end-to-end model for molecular communication in nanonetworks , 2010, IEEE Journal on Selected Areas in Communications.

[41]  Takahiro Nitta,et al.  Simulating molecular shuttle movements: towards computer-aided design of nanoscale transport systems. , 2006, Lab on a chip.