Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

[1]  D. Koev,et al.  [Insulin receptor function in subjects with above-normal body weight]. , 1990, Vutreshni bolesti.

[2]  M. Kasuga,et al.  Requirement for receptor-intrinsic tyrosine kinase activities during ligand-induced membrane ruffling of KB cells. Essential sites of src-related growth factor receptor kinases. , 1988, The Journal of biological chemistry.

[3]  D. Lebwohl,et al.  Synthesis, purification, and characterization of the cytoplasmic domain of the human insulin receptor using a baculovirus expression system. , 1988, The Journal of biological chemistry.

[4]  C. Kahn,et al.  Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. , 1988, The Journal of biological chemistry.

[5]  C. Kahn,et al.  A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. , 1988, The Journal of biological chemistry.

[6]  J. Avruch,et al.  Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells. , 1988, The Journal of biological chemistry.

[7]  O. Rosen,et al.  Reevaluation of the evidence that an antibody to the insulin receptor is insulinmimetic without activating the protein tyrosine kinase activity of the receptor. , 1987, The Journal of biological chemistry.

[8]  T. Dull,et al.  A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis. , 1987, The Journal of biological chemistry.

[9]  M. White,et al.  Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity , 1987, Cell.

[10]  O. Rosen.  After insulin binds. , 1987, Science.

[11]  W. Rutter,et al.  Heterologous transmembrane signaling by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J. Avruch,et al.  Identification of insulin receptor tyrosine residues autophosphorylated in vitro. , 1987, The Journal of biological chemistry.

[13]  A. Ullrich,et al.  Characterization of an endogenous substrate of the insulin receptor in cultured cells. , 1987, The Journal of biological chemistry.

[14]  M. Kasuga,et al.  Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell. , 1987, The Journal of biological chemistry.

[15]  D. Accili,et al.  Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Kahn Cr,et al.  Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity , 1987 .

[17]  M. Lane,et al.  Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3T3-L1 adipocytes. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[18]  A. Ullrich,et al.  Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin. , 1987, The Journal of biological chemistry.

[19]  W. Rutter,et al.  Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[20]  M. Kasuga,et al.  Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells. , 1987, The Journal of biological chemistry.

[21]  C. Kahn,et al.  Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity. , 1987, Biochemistry.

[22]  M. F. White,et al.  Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[23]  C Collins,et al.  Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. , 1986, The EMBO journal.

[24]  A. Ullrich,et al.  Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors , 1986, Nature.

[25]  M. Shibuya,et al.  Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule , 1986, Molecular and cellular biology.

[26]  O. Rosen,et al.  Phosphorylation of synthetic insulin receptor peptides by the insulin receptor kinase and evidence that the preferred sequence containing Tyr-1150 is phosphorylated in vivo. , 1986, The Journal of biological chemistry.

[27]  W. Rutter,et al.  Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose , 1986, Cell.

[28]  L. G. Davis,et al.  Basic methods in molecular biology , 1986 .

[29]  C. Kahn,et al.  7 The Insulin Receptor and Tyrosine Phosphorylation , 1986 .

[30]  Jonathan A. Cooper,et al.  6 Viral Oncogenes and Tyrosine Phosphorylation , 1986 .

[31]  J. Avruch,et al.  Kinetic properties of the insulin receptor tyrosine protein kinase: activation through an insulin-stimulated tyrosine-specific, intramolecular autophosphorylation. , 1986, Archives of biochemistry and biophysics.

[32]  O. Rosen,et al.  An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[33]  W. Rutter,et al.  Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[34]  C. Kahn,et al.  Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells , 1985, Nature.

[35]  J. Shafer,et al.  Purification of the catalytically active phosphorylated form of insulin receptor kinase by affinity chromatography with O-phosphotyrosyl-binding antibodies. , 1985, Archives of biochemistry and biophysics.

[36]  C. Kahn,et al.  Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro. , 1985, The Journal of biological chemistry.

[37]  K. Jarnagin,et al.  The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling , 1985, Cell.

[38]  P. H. Seeburg,et al.  Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes , 1985, Nature.

[39]  C. Kahn,et al.  Phosphorylation of the insulin receptor in cultured hepatoma cells and a solubilized system. , 1985, Methods in enzymology.

[40]  C. Kahn,et al.  Insulin receptor regulation and desensitization in rat hepatoma cells. The loss of the oligomeric forms of the receptor correlates with the change in receptor affinity. , 1984, The Journal of biological chemistry.

[41]  D. Melton,et al.  Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. , 1984, Nucleic acids research.

[42]  Susan S. Taylor,et al.  Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites , 1984, Nature.

[43]  P. Seeburg,et al.  Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells , 1984, Nature.

[44]  C. Kahn,et al.  Insulin Receptor Regulation and Desensitization in Rat Hepatoma Cells: Concomitant Changes in Receptor Number and in Binding Affinity , 1984, Diabetes.

[45]  M. Czech,et al.  Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity. , 1984, The Journal of biological chemistry.

[46]  C. Kahn,et al.  Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells. , 1984, The Journal of biological chemistry.

[47]  C. Kahn,et al.  Analysis of insulin action using differentiated and dedifferentiated hepatoma cells. , 1983, Endocrinology.

[48]  H. Christensen,et al.  Simultaneous regulation of amino acid influx and efflux by system A in the hepatoma cell HTC. Ouabain simulates the starvation-induced derepression of system A amino acid transport. , 1983, The Journal of biological chemistry.

[49]  M. Cobb,et al.  Phosphorylation activates the insulin receptor tyrosine protein kinase. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[50]  M. Kilberg,et al.  The regulation of neutral amino acid transport in mammalian cells. , 1983, Biochimica et biophysica acta.

[51]  V. Dall’Asta,et al.  The cluster-tray method for rapid measurement of solute fluxes in adherent cultured cells. , 1981, Analytical biochemistry.

[52]  C. Hutchison,et al.  Defined transversion mutations at a specific position in DNA using synthetic oligodeoxyribonucleotides as mutagens. , 1979, Nucleic acids research.

[53]  F. Sanger,et al.  DNA sequencing with chain-terminating inhibitors. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[54]  M. Lane,et al.  Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3 T 3L 1 adipocytes ( insulin receptor / tyrosine kinase / phosphotyrosine / phenylarsine oxide / dithiol ) , 2022 .