Central adiposity in children born small and large for gestational age.

OBJECTIVE To evaluate body composition differences between children that were born small (SGA) or large for gestational age (LGA) compared with their counterparts born adequate for gestational age (AGA). METHODS Body composition was assessed in 124 healthy Caucasian children (50% girls) aged 6-10, classified according to their birth weight for gestational age as AGA, SGA and LGA. Fat mass (FM), percentage of FM, lean mass (LM), bone mineral content (BMC) and bone mineral density were measured by dual-energy X-ray absorptiometry (DXA) in the whole body and at different body regions. RESULTS LM (adjusted for age and sex) and total BMC (adjusted for age, sex and weight) were both significantly higher in LGA children and lower in SGA when compared with those born AGA. After adjustments for height, LM and BMC differences between groups were not significant. In SGA children, truncal (P<0.05) and abdominal fatness (P<0.01) were higher when compared with both AGA and LGA children, after adjustments for age, sex and height. There were no differences in the percentage of total and central FM between children born LGA and AGA. CONCLUSIONS During childhood, children born SGA had higher central adiposity regardless of their body size. Children born LGA seem to have a higher body size but with harmonic body composition and adequate body fat distribution. Small size for gestational age at birth could programme excess abdominal fat deposition in children, which is a major factor for the clustering of cardiovascular disease risk factors defining the metabolic syndrome.

[1]  F. Chiarelli,et al.  Insulin Resistance and Oxidative Stress in Children Born Small and Large for Gestational Age , 2009, Pediatrics.

[2]  M. Sjöström,et al.  Early Life Programming of Abdominal Adiposity in Adolescents: The HELENA Study , 2009, Diabetes Care.

[3]  J. Wells,et al.  Associations between birth weight and later body composition: evidence from the 4-component model. , 2008, The American journal of clinical nutrition.

[4]  Kent L Thornburg,et al.  Effect of in Utero and Early-life Conditions on Adult Health and Disease Epidemiol Ogic a Nd Clinic a L Observations , 2022 .

[5]  L. Moreno,et al.  Small Birth Weight and Later Body Composition and Fat Distribution in Adolescents: The AVENA Study , 2008, Obesity.

[6]  F. Rasmussen,et al.  Associations of birthweight and infant growth with body composition at age 15--the COMPASS study. , 2008, Paediatric and perinatal epidemiology.

[7]  B. Heude,et al.  Postnatal weight and height growth velocities at different ages between birth and 5 y and body composition in adolescent boys and girls. , 2008, The American journal of clinical nutrition.

[8]  J. Wells,et al.  Infant growth and later body composition: evidence from the 4-component model. , 2008, The American journal of clinical nutrition.

[9]  N. Bouhours-Nouet,et al.  High Birth Weight and Early Postnatal Weight Gain Protect Obese Children and Adolescents From Truncal Adiposity and Insulin Resistance , 2008, Diabetes Care.

[10]  A. Dulloo.  Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance. , 2008, Best practice & research. Clinical endocrinology & metabolism.

[11]  B. Horta,et al.  Peso ao nascer e sndrome metablica em adultos: meta-anlise , 2008 .

[12]  M. Elia,et al.  Fetal programming of body dimensions and percentage body fat measured in prepubertal children with a 4-component model of body composition, dual-energy X-ray absorptiometry, deuterium dilution, densitometry, and skinfold thicknesses. , 2007, The American journal of clinical nutrition.

[13]  Li Liang,et al.  Metabolic syndrome in obese children born large for gestational age , 2007, Indian journal of pediatrics.

[14]  J. Wells,et al.  Programming of body composition by early growth and nutrition , 2007, Proceedings of the Nutrition Society.

[15]  J. Sorkin,et al.  Birth Weight Is Inversely Associated With Central Adipose Tissue in Healthy Children and Adolescents , 2007, Obesity.

[16]  J. Eriksson,et al.  Birth size, adult body composition and muscle strength in later life , 2007, International Journal of Obesity.

[17]  T. Cole,et al.  Promotion of Faster Weight Gain in Infants Born Small for Gestational Age: Is There an Adverse Effect on Later Blood Pressure? , 2006, Circulation.

[18]  M. Lentze,et al.  Rapid growth among term children whose birth weight was appropriate for gestational age has a longer lasting effect on body fat percentage than on body mass index. , 2006, The American journal of clinical nutrition.

[19]  M. Patti,et al.  Reductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight , 2006, Diabetologia.

[20]  P. Poulsen,et al.  Metabolic Aspects of Insulin Resistance in Individuals Born Small for Gestational Age , 2006, Hormone Research in Paediatrics.

[21]  P. Czernichow,et al.  Small for Gestational Age and the Metabolic Syndrome: Which Mechanism Is Suggested by Epidemiological and Clinical Studies? , 2006, Hormone Research in Paediatrics.

[22]  D. Dunger,et al.  Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm Weight Development Study (SWEDES). , 2006, The American journal of clinical nutrition.

[23]  J. Wells,et al.  Fetal, infant and childhood growth: relationships with body composition in Brazilian boys aged 9 years , 2005, International Journal of Obesity.

[24]  Clive Osmond,et al.  Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohort. , 2005, The American journal of clinical nutrition.

[25]  P. Taylor,et al.  Experimental models of developmental programming: consequences of exposure to an energy rich diet during development , 2005, The Journal of physiology.

[26]  I. Rogers,et al.  The influence of birthweight and intrauterine environment on adiposity and fat distribution in later life , 2003, International Journal of Obesity.

[27]  S. Heymsfield,et al.  Are dual-energy X-ray absorptiometry regional estimates associated with visceral adipose tissue mass? , 2002, International Journal of Obesity.

[28]  C. Summerbell,et al.  Childhood predictors of adult obesity: a systematic review. , 1999, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[29]  A. Hattersley,et al.  The fetal insulin hypothesis: an alternative explanation of the association of low bir thweight with diabetes and vascular disease , 1999, The Lancet.

[30]  M. Overpeck,et al.  Muscularity and Fatness of Infants and Young Children Born Small- or Large-for-Gestational-Age , 1998, Pediatrics.

[31]  L. Lubchenco,et al.  Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks. , 1966, Pediatrics.

[32]  J. Neu.  Visceral Adiposity without Overweight in Children Born Small for Gestational Age , 2009 .

[33]  B. Horta,et al.  [Birth weight and metabolic syndrome in adults: meta-analysis]. , 2008, Revista de saude publica.

[34]  L. Moreno,et al.  Early programming of body composition and fat distribution in adolescents. , 2006, The Journal of nutrition.

[35]  G. Mcneill,et al.  Usefulness of anthropometry and DXA in predicting intra-abdominal fat in obese men and women. , 2000, Obesity research.

[36]  S. Featherstone,et al.  Association between postnatal catch›up growth and obesity in childhood: prospective cohort study , 2000 .