Longitudinal Studies on the Rate of Decline in Renal Function with Age

Serial creatinine clearances (5 to 14 studies) were obtained for 446 normal volunteers in the Baltimore Longitudinal Study of Aging followed between 1958 and 1981. When those subjects with possible renal or urinary tract disease and subjects on diuretics and antihypertensives were removed from the study, leaving a group of 254 “normal” subjects, the mean decrease in creatinine clearance was 0.75 ml/min/year. The slopes of the creatinine clearance vs. time fell into a normal (Gaussian) distribution around this mean. One third of all subjects followed had no absolute decrease in renal function (positive slope of creatinine clearance vs. time) and there was a small group of patients who showed a statistically significant increase (P < 0.05) in creatinine clearance with age.

[1]  B. Brenner,et al.  Hemodynamically mediated glomerular injury and the progressive nature of kidney disease. , 1983, Kidney international.

[2]  Brenner Bm.  Hemodynamically mediated glomerular injury and the progressive nature of kidney disease. , 1983 .

[3]  Mogensen Ce.  Renal function changes in diabetes. , 1976 .

[4]  A. Ljungqvist.  STRUCTURE OF THE ARTERIOLE-GLOMERULAR UNITS IN DIFFERENT ZONES OF THE KIDNEY. MICRO-ANGIOGRAPHIC AND HISTOLOGIC EVIDENCE OF AN EXTRAGLOMERULAR MEDULLARY CIRCULATION. , 1964, Nephron.

[5]  D. Ogden.  Donor and recipient function 2 to 4 years after renal homotransplantation , 1968 .

[6]  N. Shock,et al.  Age differences in the succinoxidase activity of homogenates and mitochondria from the livers and kidneys of rats. , 1960, Journal of gerontology.

[7]  D. B. MacCallum.  The bearing of degenerating glomeruli on the problem of the vascular supply of the mammalian kidney , 1939 .

[8]  A. H. Norris,et al.  Activities and attitudes of participants in the Baltimore longitudinal study. , 1966, Journal of gerontology.

[9]  D. Ogden.  Donor and recipient function 2 to 4 years after renal homotransplantation. A paired study of 28 cases. , 1967, Annals of internal medicine.

[10]  C. B. Kahn,et al.  Kidney Size in Diabetes Mellitus , 1974, Diabetes.

[11]  R. Burich.  Effects of age on renal function and enzyme activity in male C57BL/6 mice. , 1975, Journal of gerontology.

[12]  N. Sawabu,et al.  Intrarenal vascular changes with age and disease. , 1972, Kidney international.

[13]  A. H. Norris,et al.  The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. , 1976, Journal of gerontology.

[14]  L. Hayflick.  The cell biology of human aging. , 1976, Scientific American.

[15]  R. Hare,et al.  Endogenous Creatinine in Serum and Urine.∗ † , 1950, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[16]  R. Rieselbach,et al.  Factors influencing the increase in glomerular filtration rate in the remaining kidney of transplant donors. , 1973, The American journal of medicine.

[17]  A. Dontas,et al.  The effect of bacteriuria on renal functional patterns in old age. , 1968, Clinical science.

[18]  A. Alving,et al.  CHANGES WITH AGE IN THE RENAL FUNCTION IN ADULT MEN , 1938 .

[19]  P. Wilson,et al.  Enzyme patterns in young and old mouse kidneys. , 1971, Gerontologia.

[20]  W. Couser,et al.  The immunopathology of the aging rat kidney. , 1976, Journal of gerontology.

[21]  A. Raizner,et al.  Functional defects in the aging kidney. , 1972, Annals of internal medicine.

[22]  S. Wolfson,et al.  EPIDEMIOLOGY OF BACTERIURIA IN A PREDOMINANTLY GERIATRIC MALE POPULATION , 1965, The American journal of the medical sciences.

[23]  J. K. Healy.  Clinical assessment of glomerular filtration rate by different forms of creatinine clearance and a modified urinary phenolsulphonphthalein excretion test. , 1968, The American journal of medicine.

[24]  N. Shock,et al.  Association between blood pressure and the rate of decline in renal function with age. , 1984, Kidney international.

[25]  S. Klahr,et al.  Role of dietary factors in the progression of chronic renal disease. , 1983, Kidney international.

[26]  F. Shimizu,et al.  On the age-associated presence of immunoglobulin and complement in the renal glomeruli of mice. , 1977, Contributions to nephrology.

[27]  D F DAVIES,et al.  Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. , 1950, The Journal of clinical investigation.

[28]  C. Mogensen.  Renal function changes in diabetes. , 1976, Diabetes.

[29]  B. Brenner,et al.  Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. , 1982, The New England journal of medicine.