An electrochemical sensor based on molecularly imprinted polypyrrole/graphene quantum dots composite for detection of bisphenol A in water samples

Abstract Bisphenol A (BPA) is an important endocrine disrupter in environments, for which sensitive and selective detection methods are highly necessary to carry out its recognition and quantification. Here a novel electrochemical sensor was developed based on molecularly imprinted polypyrrole/graphene quantum dots (MIPPy/GQDs) composite for the detection of bisphenol A (BPA) in water samples. A MIPPy/GQDs composite layer was prepared by the electropolymerization of pyrrole on a glassy carbon electrode with BPA as a template. The MIPPy/GQDs composite could specifically recognize BPA in aqueous solutions, which resulted in the decrease of peak currents of K 3 [Fe(CN) 6 ] at the MIPPy/GQDs) modified electrode in cyclic voltammetry (CV) and differential pulse voltammetry (DPV). There was a linear relationship between BPA concentrations ranging from 0.1 μM to 50 μM and the response value ( ΔI DPV ) in DPV, with a limit of detection of 0.04 μM (S/N = 3). The sensor was applied for the detection of BPA in tap and sea water samples, with recoveries of 94.5% and 93.7%, respectively. The proposed method provides a powerful tool for rapid and sensitive detection of BPA in environmental samples.

[1]  M. Shamsipur,et al.  Dispersive liquid-liquid microextraction combined with high-performance liquid chromatography-UV detection as a very simple, rapid and sensitive method for the determination of bisphenol A in water samples. , 2009, Journal of chromatography. A.

[2]  A. Ballesteros-Gómez,et al.  Single-step extraction and cleanup of bisphenol A in soft drinks by hemimicellar magnetic solid phase extraction prior to liquid chromatography/tandem mass spectrometry. , 2013, Analytica chimica acta.

[3]  Jing Zhao,et al.  Graphene quantum dots-based platform for the fabrication of electrochemical biosensors , 2011 .

[4]  Samuel P. Caudill,et al.  Urinary Concentrations of Bisphenol A and 4-Nonylphenol in a Human Reference Population , 2004, Environmental health perspectives.

[5]  É. Gaudreau,et al.  Determination of bisphenol A, triclosan and their metabolites in human urine using isotope-dilution liquid chromatography-tandem mass spectrometry. , 2014, Journal of chromatography. A.

[6]  Fangzhuan Liu,et al.  Preparation of polypyrrole/graphene nanosheets composites with enhanced thermoelectric properties , 2014 .

[7]  K. Choi,et al.  Direct synthesis of graphene quantum dots from multilayer graphene flakes through grinding assisted co-solvent ultrasonication for all-printed resistive switching arrays , 2016 .

[8]  Wei Qin,et al.  Potentiometric sensor for determination of neutral bisphenol A using a molecularly imprinted polymer as a receptor , 2013, Analytical and Bioanalytical Chemistry.

[9]  B. Le Bizec,et al.  Development and validation of a specific and sensitive gas chromatography tandem mass spectrometry method for the determination of bisphenol A residues in a large set of food items. , 2014, Journal of chromatography. A.

[10]  Youngkwan Lee,et al.  Highly sensitive and selective determination of bisphenol-A using peptide-modified gold electrode. , 2014, Biosensors & bioelectronics.

[11]  S. Rubio,et al.  Determination of urinary bisphenol A by coacervative microextraction and liquid chromatography-fluorescence detection. , 2008, Analytica chimica acta.

[12]  A. Özcan.  Synergistic Effect of Lithium Perchlorate and Sodium Hydroxide in the Preparation of Electrochemically Treated Pencil Graphite Electrodes for Selective and Sensitive Bisphenol A Detection in Water Samples , 2014 .

[13]  Lili Zhu,et al.  Electrochemical sensor based on magnetic molecularly imprinted nanoparticles at surfactant modified magnetic electrode for determination of bisphenol A. , 2014, Biosensors & bioelectronics.

[14]  He Li,et al.  Electrochemical bisphenol A sensor based on core–shell multiwalled carbon nanotubes/graphene oxide nanoribbons , 2015 .

[15]  Qiang Wang,et al.  Aptamer-functionalized nanoporous gold film for high-performance direct electrochemical detection of bisphenol A in human serum. , 2015, Analytica chimica acta.

[16]  S. Bose,et al.  In-situ synthesis and characterization of electrically conductive polypyrrole/graphene nanocomposites , 2010 .

[17]  Jiadong Huang,et al.  Electrochemical sensor for bisphenol A detection based on molecularly imprinted polymers and gold nanoparticles , 2011 .

[18]  Yanbin Li,et al.  An electrochemical aptasensor based on gold nanoparticles dotted graphene modified glassy carbon electrode for label-free detection of bisphenol A in milk samples. , 2014, Food chemistry.

[19]  X. Quan,et al.  Preparation and evaluation of molecularly imprinted solid-phase microextraction fibers for selective extraction of bisphenol A in complex samples. , 2009, Journal of chromatography. A.

[20]  Rigoberto C. Advincula,et al.  Electropolymerized Molecularly Imprinted Polymer Film: EIS Sensing of Bisphenol A , 2011 .

[21]  Peihong Deng,et al.  Acetylene black paste electrode modified with a molecularly imprinted chitosan film for the detection of bisphenol A , 2013, Microchimica Acta.

[22]  Mi-Sook Won,et al.  Label‐Free Detection of Bisphenol A Using a Potentiometric Immunosensor , 2008 .

[23]  Bai Yang,et al.  Surface Chemistry Routes to Modulate the Photoluminescence of Graphene Quantum Dots: From Fluorescence Mechanism to Up‐Conversion Bioimaging Applications , 2012 .

[24]  Zhenghe Xu,et al.  Electrochemical detection of bisphenol A mediated by [Ru(bpy)(3)](2+) on an ITO electrode. , 2010, Journal of hazardous materials.

[25]  Bai Yang,et al.  Graphene quantum dots with controllable surface oxidation, tunable fluorescence and up-conversion emission , 2012 .

[26]  R. Carabias-Martínez,et al.  Use of a bisphenol-A imprinted polymer as a selective sorbent for the determination of phenols and phenoxyacids in honey by liquid chromatography with diode array and tandem mass spectrometric detection. , 2009, Analytica chimica acta.

[27]  Robert B Wallace,et al.  Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. , 2008, JAMA.

[28]  Guohua Zhao,et al.  A Novel Photoelectrochemical Sensor for Bisphenol A with High Sensitivity and Selectivity Based on Surface Molecularly Imprinted Polypyrrole Modified TiO2 Nanotubes , 2013 .

[29]  Kyung-Hwa Yoo,et al.  Aptamer-modified anodized aluminum oxide-based capacitive sensor for the detection of bisphenol A , 2011 .

[30]  M. Roushani,et al.  Novel electrochemical sensor based on graphene quantum dots/riboflavin nanocomposite for the detection of persulfate , 2014 .

[31]  Muhammad J A Shiddiky,et al.  An impedimetric immunosensor for the label-free detection of bisphenol A. , 2007, Biosensors & bioelectronics.

[32]  Md Azahar Ali,et al.  Self assembled DC sputtered nanostructured rutile TiO₂ platform for bisphenol A detection. , 2015, Biosensors & bioelectronics.

[33]  Zhongping Zhang,et al.  Surface molecular self-assembly for organophosphate pesticide imprinting in electropolymerized poly(p-aminothiophenol) membranes on a gold nanoparticle modified glassy carbon electrode. , 2010, Analytical chemistry.

[34]  Haiying Yu,et al.  Electrochemical determination of bisphenol A with a glassy carbon electrode modified with gold nanodendrites , 2015, Microchimica Acta.

[35]  Da Chen,et al.  Graphene oxide: preparation, functionalization, and electrochemical applications. , 2012, Chemical reviews.

[36]  R. Ito,et al.  Liquid phase microextraction with in situ derivatization for measurement of bisphenol A in river water sample by gas chromatography-mass spectrometry. , 2006, Journal of chromatography. A.