An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms

A functional polymorphism in the regulatory region of the serotonin transporter gene has been reported to be associated with anxiety-related personality traits.1 We attempted to replicate this finding in an association study involving 759 Caucasians selected from the general Australian population. We found no associations with personality traits (including neuroticism, negative affect and behavioral inhibition), anxiety and depressive symptoms, or alcohol misuse.

[1]  S. Nanko,et al.  Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder , 1997, Molecular Psychiatry.

[2]  K. Lesch,et al.  Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region , 1996, Science.

[3]  R. Murray,et al.  A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. , 1996, Molecular psychiatry.

[4]  B. Rodgers.  Behaviour and personality in childhood as predictors of adult psychiatric disorder. , 1990, Journal of child psychology and psychiatry, and allied disciplines.

[5]  R. Ebstein,et al.  No association between the serotonin transporter gene regulatory region polymorphism and the Tridimensional Personality Questionnaire (TPQ) temperament of harm avoidance , 1997, Molecular Psychiatry.

[6]  C. Carver,et al.  Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS/BAS Scales , 1994 .

[7]  F. Poustka,et al.  Serotonin transporter gene-linked polymorphic region: allele distributions in relationship to body weight and in anorexia nervosa. , 1997, Life sciences.

[8]  M. Nöthen,et al.  Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder. , 1997, Psychiatric genetics.

[9]  G. Kirov,et al.  Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease , 1997, Neuroreport.

[10]  K. Lesch,et al.  Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence. , 1997, Alcoholism, clinical and experimental research.

[11]  O. Aasland,et al.  Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. , 1993, Addiction.

[12]  S. Kanba,et al.  Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in the Japanese. , 1997, American journal of medical genetics.

[13]  T. Arinami,et al.  An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population , 1997, Psychiatry and clinical neurosciences.

[14]  D. Ball,et al.  The serotonin transporter gene and peer‐rated neuroticism , 1997, Neuroreport.

[15]  C. Robert Cloninger.  A systematic method for clinical description and classification of personality variants. A proposal. , 1987, Archives of general psychiatry.

[16]  Kyle Kercher,et al.  Assessing Subjective Well-Being in the Old-Old , 1992 .

[17]  P. Duncan-Jones,et al.  Detecting anxiety and depression in general medical settings. , 1988, BMJ.

[18]  S. Higuchi,et al.  Serotonin transporter gene regulatory region polymorphism and panic disorder , 1997, Molecular Psychiatry.

[19]  A. Bedford,et al.  A new personal disturbance scale (DSSI/sAD). , 1976, The British journal of social and clinical psychology.

[20]  P Riederer,et al.  Allelic Variation of Human Serotonin Transporter Gene Expression , 1996, Journal of neurochemistry.