Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis.

[1]  Edward T Naureckas,et al.  Non-cystic fibrosis bronchiectasis. , 2013, American journal of respiratory and critical care medicine.

[2]  A. Hill,et al.  Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis. , 2012, American journal of respiratory and critical care medicine.

[3]  N. Karalus,et al.  Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial , 2012, The Lancet.

[4]  Kyle Bittinger,et al.  Topographical continuity of bacterial populations in the healthy human respiratory tract. , 2011, American journal of respiratory and critical care medicine.

[5]  A. Churg,et al.  AZD9668: Pharmacological Characterization of a Novel Oral Inhibitor of Neutrophil Elastase , 2011, Journal of Pharmacology and Experimental Therapeutics.

[6]  A. Bush,et al.  The Th17 pathway in cystic fibrosis lung disease. , 2011, American journal of respiratory and critical care medicine.

[7]  G. Grondin,et al.  Infection of Polarized Airway Epithelial Cells by Normal and Small-Colony Variant Strains of Staphylococcus aureus Is Increased in Cells with Abnormal Cystic Fibrosis Transmembrane Conductance Regulator Function and Is Influenced by NF-κB , 2011, Infection and Immunity.

[8]  S. Holland,et al.  Trends in bronchiectasis among medicare beneficiaries in the United States, 2000 to 2007. , 2011, Chest.

[9]  G. Fleming,et al.  Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis: A review and meta-analysis. , 2011, Glycobiology.

[10]  T. S. Wilkinson,et al.  A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis. , 2011, American journal of respiratory and critical care medicine.

[11]  R. Stockley,et al.  Vitamin D-binding protein contributes to COPD by activation of alveolar macrophages , 2011, Thorax.

[12]  A. Akram,et al.  Statins in community acquired pneumonia: Evidence from experimental and clinical studies. , 2010, Respiratory medicine.

[13]  D Bilton,et al.  British Thoracic Society guideline for non-CF bronchiectasis , 2010, Thorax.

[14]  B. Fevang,et al.  Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors. , 2010, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[15]  G. O’Toole,et al.  Pseudomonas aeruginosa Evasion of Phagocytosis Is Mediated by Loss of Swimming Motility and Is Independent of Flagellum Expression , 2010, Infection and Immunity.

[16]  Arthur S Slutsky,et al.  Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs. , 2009, American journal of respiratory and critical care medicine.

[17]  C. Di Serio,et al.  Pseudomonas aeruginosa microevolution during cystic fibrosis lung infection establishes clones with adapted virulence. , 2009, American journal of respiratory and critical care medicine.

[18]  J. Davies,et al.  Bugs, biofilms, and resistance in cystic fibrosis. , 2009, Respiratory care.

[19]  D. Hansell,et al.  Mortality in bronchiectasis: a long-term study assessing the factors influencing survival , 2009, European Respiratory Journal.

[20]  K. Malcolm,et al.  Neutrophil enhancement of Pseudomonas aeruginosa biofilm development: human F-actin and DNA as targets for therapy , 2009, Journal of medical microbiology.

[21]  E. Kerwin,et al.  A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. , 2009, American journal of respiratory and critical care medicine.

[22]  A. Chang,et al.  Inhaled steroids for bronchiectasis. , 2009, The Cochrane database of systematic reviews.

[23]  M. Matsushita,et al.  Stable bronchiectasis is associated with low serum L‐ficolin concentrations , 2009, The clinical respiratory journal.

[24]  J. Kolls,et al.  Th17 cytokines and mucosal immunity , 2008, Immunological reviews.

[25]  J. Elborn,et al.  Neutrophils in cystic fibrosis , 2008, Thorax.

[26]  E. Chilvers,et al.  Advances in neutrophil biology: clinical implications. , 2008, Chest.

[27]  S. Hodge,et al.  Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease. , 2008, American journal of respiratory and critical care medicine.

[28]  D. Altmann,et al.  Human leucocyte antigen class II association in idiopathic bronchiectasis, a disease of chronic lung infection, implicates a role for adaptive immunity , 2008, Clinical and experimental immunology.

[29]  J. Lordan,et al.  Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[30]  J. Soriano,et al.  Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis. , 2007, Chest.

[31]  Michael J. Allingham,et al.  RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration , 2007, The Journal of cell biology.

[32]  J. Elborn,et al.  The effect of treatment of cystic fibrosis pulmonary exacerbations on airways and systemic inflammation , 2007, Pediatric pulmonology.

[33]  S. Rennard,et al.  The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. , 2007, American journal of respiratory and critical care medicine.

[34]  M. Greenstone,et al.  Prolonged antibiotics for purulent bronchiectasis in children and adults. , 2007, The Cochrane database of systematic reviews.

[35]  L. Notarangelo,et al.  Genetic Causes of Bronchiectasis: Primary Immune Deficiencies and the Lung , 2007, Respiration.

[36]  R. Wilson,et al.  The effect of Pseudomonas aeruginosa on pulmonary function in patients with bronchiectasis , 2006, European Respiratory Journal.

[37]  P. McCray,et al.  Haemophilus influenzae forms biofilms on airway epithelia: implications in cystic fibrosis. , 2006, American journal of respiratory and critical care medicine.

[38]  C. Scheiermann,et al.  Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils , 2006, The Journal of experimental medicine.

[39]  P. Hutchinson,et al.  Assessing immune function in adult bronchiectasis , 2006, Clinical and experimental immunology.

[40]  J. Trowsdale,et al.  HLA-C and killer cell immunoglobulin-like receptor genes in idiopathic bronchiectasis. , 2006, American journal of respiratory and critical care medicine.

[41]  B. Fevang,et al.  Common variable immunodeficiency and the complement system; low mannose‐binding lectin levels are associated with bronchiectasis , 2005, Clinical and experimental immunology.

[42]  E. Andrès,et al.  Clinical and immunological aspects of HLA class I deficiency. , 2005, QJM : monthly journal of the Association of Physicians.

[43]  C. Haslett,et al.  Regulation of neutrophil apoptosis and removal of apoptotic cells. , 2005, Current drug targets. Inflammation and allergy.

[44]  F. Luscinskas,et al.  ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. , 2005, Blood.

[45]  M. Kosorok,et al.  Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis. , 2005, JAMA.

[46]  D. Look,et al.  Modulation of airway inflammation and bacterial clearance by epithelial cell ICAM-1. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[47]  M. Tabrizi,et al.  Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study. , 2004, Chest.

[48]  M. Mishima,et al.  Bronchial dilatation in asthma: relation to clinical and sputum indices. , 2004, Chest.

[49]  M. Ennis,et al.  Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis , 2004, Thorax.

[50]  J. Elborn,et al.  Bronchiectasis in secondary care: a comprehensive profile of a neglected disease. , 2003, European journal of internal medicine.

[51]  P. Davis,et al.  State of the Art: Why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection? , 2003, Respiratory research.

[52]  S. Molin,et al.  Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants , 2003, Molecular microbiology.

[53]  P. Hutchinson,et al.  Adaptive immunity to nontypeable Haemophilus influenzae. , 2003, American journal of respiratory and critical care medicine.

[54]  A Stead,et al.  Humoral immunity and bronchiectasis , 2002, Clinical and experimental immunology.

[55]  K. Brown,et al.  Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. , 2002, The Journal of clinical investigation.

[56]  R. Proctor,et al.  Characteristics of Staphylococcus aureus, isolated from airways of cystic fibrosis patients, and their small colony variants. , 2002, FEMS immunology and medical microbiology.

[57]  R. Rodríguez-Roisín,et al.  Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors , 2002, Thorax.

[58]  C. Agustí,et al.  Bronchial inflammation and colonization in patients with clinically stable bronchiectasis. , 2001, American journal of respiratory and critical care medicine.

[59]  G. Ooi,et al.  Macrophages, neutrophils and tumour necrosis factor-alpha expression in bronchiectatic airways in vivo. , 2001, Respiratory medicine.

[60]  S. Cramton,et al.  Anaerobic Conditions Induce Expression of Polysaccharide Intercellular Adhesin in Staphylococcus aureus and Staphylococcus epidermidis , 2001, Infection and Immunity.

[61]  M. Ip,et al.  Neutrophil-mediated degradation of lung proteoglycans: stimulation by tumor necrosis factor-alpha in sputum of patients with bronchiectasis. , 2000, American journal of respiratory and critical care medicine.

[62]  Matthew R. Parsek,et al.  Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms , 2000, Nature.

[63]  G. Tipoe,et al.  Up-regulation of circulating adhesion molecules in bronchiectasis. , 2000, The European respiratory journal.

[64]  M. Keogan,et al.  An investigation into causative factors in patients with bronchiectasis. , 2000, American journal of respiratory and critical care medicine.

[65]  R. Stockley,et al.  Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis. , 2000, The American journal of medicine.

[66]  A. Oliver,et al.  High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. , 2000, Science.

[67]  R. Stockley,et al.  Validation of assays for inflammatory mediators in sputum. , 2000, The European respiratory journal.

[68]  G. Ooi,et al.  Sputum elastase in steady-state bronchiectasis. , 2000, Chest.

[69]  R. Wilson,et al.  Determinants of chronic infection with Staphylococcus aureus in patients with bronchiectasis. , 1999, The European respiratory journal.

[70]  C. Haslett.  Granulocyte apoptosis and its role in the resolution and control of lung inflammation. , 1999, American journal of respiratory and critical care medicine.

[71]  M. Schwartz,et al.  Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. , 1999, The Journal of clinical investigation.

[72]  B. Fischer,et al.  Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. , 1999, American journal of physiology. Lung cellular and molecular physiology.

[73]  Wai Lam,et al.  A pilot study of low-dose erythromycin in bronchiectasis. , 1999, The European respiratory journal.

[74]  K. Yuen,et al.  Inhaled fluticasone reduces sputum inflammatory indices in severe bronchiectasis. , 1998, American journal of respiratory and critical care medicine.

[75]  R. Braun,et al.  Evidence for eosinophil activation in bronchiectasis unrelated to cystic fibrosis and bronchopulmonary aspergillosis: discrepancy between blood eosinophil counts and serum eosinophil cationic protein levels , 1998, Thorax.

[76]  R. Stockley,et al.  IgG subclasses in the serum and sputum from patients with bronchiectasis , 1998, Thorax.

[77]  R. Proctor,et al.  Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosis. , 1998, The Journal of infectious diseases.

[78]  L. Couderc,et al.  Accelerated obstructive pulmonary disease in HIV infected patients with bronchiectasis. , 1998, The European respiratory journal.

[79]  R. Stockley,et al.  The chemotactic activity of sputum from patients with bronchiectasis. , 1998, American journal of respiratory and critical care medicine.

[80]  James M. Wilson,et al.  Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis , 1997, Cell.

[81]  E. Greenberg,et al.  Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid , 1996, Cell.

[82]  M. Nicotra,et al.  Clinical, pathophysiologic, and microbiologic characterization of bronchiectasis in an aging cohort. , 1995, Chest.

[83]  H. Lode,et al.  Cells and Cytokines in Chronic Bronchial Infection , 1994, Annals of the New York Academy of Sciences.

[84]  A. Lindberg,et al.  Haemophilus influenzae resides and multiplies intracellularly in human adenoid tissue as demonstrated by in situ hybridization and bacterial viability assay , 1994, Infection and immunity.

[85]  R. Davies,et al.  Airway epithelial cells and mediators of inflammation. , 1993, Respiratory medicine.

[86]  J. Montserrat,et al.  Sputum sol phase proteins and elastase activity in patients with clinically stable bronchiectasis. , 1992, Thorax.

[87]  R. Schleimer,et al.  Do cytokines play a role in leukocyte recruitment and activation in the lungs? , 1991, The American review of respiratory disease.

[88]  M. Berger,et al.  Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch. , 1990, The Journal of clinical investigation.

[89]  D. Dearborn,et al.  Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas-infected lung in cystic fibrosis. , 1989, The Journal of clinical investigation.

[90]  P. Cole,et al.  The immunological component of the cellular inflammatory infiltrate in bronchiectasis. , 1989, Thorax.

[91]  R. Stockley,et al.  Neutrophil chemotaxis in bronchiectasis: a study of peripheral cells and lung secretions. , 1988, Clinical science.

[92]  R. Robbins,et al.  Complement Activation in Cystic Fibrosis Respiratory Fluids: in Vivo and in Vitro Generation of C5a and Chemotactic Activity , 1986, Pediatric Research.

[93]  J. Gee,et al.  Proteins of the cystic fibrosis respiratory tract. Fragmented immunoglobulin G opsonic antibody causing defective opsonophagocytosis. , 1984, The Journal of clinical investigation.

[94]  R. Stockley,et al.  Elastolytic activity of sputum and its relation to purulence and to lung function in patients with bronchiectasis. , 1984, Thorax.

[95]  J. Maurer.  Trends and Burden of Bronchiectasis-Associated Hospitalizations in the United States, 1993-2006 , 2011 .

[96]  A. Hill,et al.  Non-cystic fibrosis bronchiectasis. , 2009, Clinical medicine.

[97]  M. Raza.  Factors Associated With Lung Function Decline in Adult Patients With Stable Non-Cystic Fibrosis Bronchiectasis , 2009 .

[98]  R. Sepper,et al.  Presence, activities, and molecular forms of cathepsin G, elastase,α1-antitrypsin, andα1-antichymotrypsin in bronchiectasis , 2005, Journal of Clinical Immunology.

[99]  M. Royal,et al.  Lung function in bronchiectasis: the influence of Pseudomonas aeruginosa , 1996 .

[100]  R. Sepper,et al.  Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis. , 1995, Journal of clinical immunology.

[101]  M P Bevilacqua,et al.  Endothelial-leukocyte adhesion molecules. , 1993, Annual review of immunology.

[102]  I. Lauder,et al.  Multivariate analysis of factors affecting pulmonary function in bronchiectasis. , 1993, Respiration; international review of thoracic diseases.

[103]  R. Stockley,et al.  Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium. , 1991, American journal of respiratory cell and molecular biology.

[104]  Coletsos Pj.  Inflammation: a two-edged sword--the model of bronchiectasis. , 1986 .