Optimal Cognitive Distance and Absorptive Capacity

The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4 T cell immune responses by identifying compounds that block the interaction of CD4 and MHC, class II, gene products and a method of treatment which comprises administering such an identified compound. The compounds that inhibit undesired human CD4 T cell immune responses can be used to treat disease such as multiple sclerosis and to prevent graft rejection and graft versus host disease. More specifically, the application concerns compounds having molecular weights between about 1400 and 400 that mimic three portions of the human CD4 lymphocyte cell surface antigen. The portions are residues 29-35, the C-C' loop of the D1 domain; residues 317-323, the C-C' loop of the D4 domain; and residues 346-353, the CDR3 or FG ridge of the D4 domain of the CD4 molecule. Specific examples of such compounds include cyclic peptides and peptidomimetic.

[1]  Toby E. Stuart,et al.  Local search and the evolution of technological capabilities , 2007 .

[2]  Howard Thomas,et al.  Strategic Discovery: Competing in New Arenas , 1997 .

[3]  J. Hagedoorn,et al.  The effect of strategic technology alliances on company performance. , 1994 .

[4]  Bart Nooteboom,et al.  Empirical Tests of Optimal Cognitive Distance , 2004 .

[5]  R. Gulati.  Social Structure and Alliance Formation Patterns: A Longitudinal Analysis , 1995 .

[6]  Daniel A. Levinthal,et al.  ABSORPTIVE CAPACITY: A NEW PERSPECTIVE ON LEARNING AND INNOVATION , 1990 .

[7]  George J. Stigler,et al.  The Organization of Industry , 1969 .

[8]  Bart Nooteboom,et al.  Inter-firm alliances: Analysis and design , 1999 .

[9]  Koenraad Debackere,et al.  Knowledge Sharing Mechanisms in Industrial Research , 2006 .

[10]  Lee Fleming,et al.  Special Issue on Design and Development: Recombinant Uncertainty in Technological Search , 2001, Manag. Sci..

[11]  Harry G. Barkema,et al.  Working abroad, working with others: How firms learn to operate international joint ventures , 1997 .

[12]  Curba Morris Lampert,et al.  Entrepreneurship in the large corporation: a longitudinal study of how established firms create breakthrough inventions , 2001 .

[13]  Rosemarie H. Ziedonis,et al.  The patent paradox revisited: an empirical study of patenting in the U , 2001 .

[14]  Bart Nooteboom,et al.  Tilburg University Empirical Tests of Optimal Cognitive Distance Wuyts , 2005 .

[15]  F. Narin,et al.  Patents as indicators of corporate technological strength , 1987 .

[16]  N. Venkatraman,et al.  Knowledge relatedness and the performance of multibusiness firms , 2005 .

[17]  Daniel A. Levinthal,et al.  The myopia of learning , 1993 .

[18]  Lori Rosenkopf,et al.  Overcoming Local Search Through Alliances and Mobility , 2003, Manag. Sci..

[19]  G. Ahuja.  Collaboration Networks, Structural Holes, and Innovation: A Longitudinal Study , 1998 .

[20]  Edwin R. Otto.  Innovation: The Attacker's Advantage , 1986 .

[21]  B. Uzzi,et al.  Social Structure and Competition in Interfirm Networks: The Paradox of Embeddedness , 1997 .

[22]  P. Ring,et al.  Developmental Processes of Cooperative Interorganizational Relationships , 1994 .

[23]  Alessandro Nuvolari,et al.  Collective invention during the British , 2004 .

[24]  D. Teece,et al.  DYNAMIC CAPABILITIES AND STRATEGIC MANAGEMENT , 1997 .

[25]  Nick von Tunzelmann,et al.  Patents and productivity: (The University of Chicago Press, 1984) pp. 512, [UK pound]15.25. (paperback edition, 1987.) , 1989 .

[26]  A. P. Man,et al.  Transitory Alliances: An Instrument for Surviving Turbulent Industries? , 2003 .

[27]  Lori Rosenkopf.  BEYOND LOCAL SEARCH : BOUNDARY-SPANNING , EXPLORATION AND IMPACT IN THE OPTICAL DISC INDUSTRY Running Head : “ Beyond Local Search ” , 2000 .

[28]  R. Katila,et al.  Technological acquisitions and the innovation performance of acquiring firms: a longitudinal study , 2001 .

[29]  R. Gulati,et al.  Where Do Interorganizational Networks Come From?1 , 1999, American Journal of Sociology.

[30]  Will Mitchell,et al.  The influence of local search and performance heuristics on new design introduction in a new product market , 1998 .

[31]  E. L. Cox,et al.  Guest editors\' introduction to the special issue: why is there a resource-based view? Toward a theory of competitive heterogeneity , 2003 .

[32]  M. Porter.  Competition in Global Industries , 1986 .

[33]  K. Weick.  The social psychology of organizing , 1969 .

[34]  J. Johanson,et al.  The Internationalization Process of the Firm—A Model of Knowledge Development and Increasing Foreign Market Commitments , 1977 .

[35]  Constance E. Helfat,et al.  Evolutionary trajectories in petroleum firm R&D , 1994 .

[36]  J. March.  Exploration and exploitation in organizational learning , 1991, STUDI ORGANIZZATIVI.

[37]  P. Berger,et al.  Social Construction of Reality , 1991, The SAGE International Encyclopedia of Mass Media and Society.

[38]  J. Hagedoorn.  Understanding the rationale of strategic technology partnering: Nterorganizational modes of cooperation and sectoral differences , 1993 .

[39]  Toby E. Stuart.  Network Positions and Propensities to Collaborate: An Investigation of Strategic Alliance Formation in a High-Technology Industry , 1998 .

[40]  J. Johanson,et al.  The Mechanism of Internationalisation , 1990 .

[41]  Gavin J. Wright.  An evolutionary theory of economic change , 1982 .

[42]  B. Nooteboom.  Towards a dynamic theory of transactions , 1992 .

[43]  M. Ho.  Differences between European regional innovation systems in terms of technological and economic characteristics , 2004 .

[44]  W. Powell,et al.  Interorganizational Collaboration and the Locus of Innovation: Networks of Learning in Biotechnology. , 1996 .

[45]  Z. Griliches,et al.  Econometric Models for Count Data with an Application to the Patents-R&D Relationship , 1984 .

[46]  G. Ahuja.  The duality of collaboration : Inducements and opportunities in the formation of interfirm linkages , 2000 .

[47]  Zvi Griliches,et al.  Estimating Distributed Lags in Short Panels with an Application to the Specification of Depreciation Patterns and Capital Stock Constructs , 1982 .

[48]  Jojo Jacob,et al.  Productivity gains, intersectoral linkages, and trade : Indonesian manufacturing, 1980-1996 , 2004 .

[49]  I. Cockburn,et al.  Scale, scope, and spillovers: the determinants of research productivity in drug discovery. , 1996, The Rand journal of economics.

[50]  J. R. Moore,et al.  The theory of the growth of the firm twenty-five years after , 1960 .

[51]  European Productivity Gaps: Is R&D the solution? , 2004 .

[52]  N. Nohria,et al.  Global strategic linkages and industry structure , 1991 .

[53]  B. Wernerfelt,et al.  A Resource-Based View of the Firm , 1984 .

[54]  B. Kogut,et al.  Localization of Knowledge and the Mobility of Engineers in Regional Networks , 1999 .

[55]  Bart Nooteboorn,et al.  Entry, spending and firm size in a stochastic R&D race , 1991 .

[56]  David B. Audretsch,et al.  Innovation in Large and Small Firms: An Empirical Analysis , 1988 .

[57]  Bart Nooteboom,et al.  Co-evolution in innovation systems : the case of pharmaceutical biotechnology , 2004 .

[58]  J. Shaver,et al.  Does international research and development increase patent output? An analysis of Japanese pharmaceutical firms , 2005 .

[59]  J. Barney.  Firm Resources and Sustained Competitive Advantage , 1991 .

[60]  R. Gulati.  Does Familiarity Breed Trust? The Implications of Repeated Ties for Contractual Choice in Alliances , 1995 .

[61]  B. Nooteboom.  Learning and Innovation in Organizations and Economies , 2000 .

[62]  Jeffrey Pfeffer,et al.  Joint Ventures and Interorganizational Interdependence , 1976 .

[63]  I. Cockburn,et al.  Scale, Scope and Spillovers: The Determinants of Research Productivity in the Pharmaceutical Industry , 1993 .

[64]  Mcdp Mathieu Weggeman,et al.  All ye need to know? : aesthetics from a design perspective , 2004 .

[65]  K. Weick.  FROM SENSEMAKING IN ORGANIZATIONS , 2021, The New Economic Sociology.

[66]  M. Porter.  The Competitive Advantage Of Nations , 1990 .

[67]  C. Prahalad,et al.  The Core Competence of the Corporation , 1990 .

[68]  J. Ruiz Moreno.  [Organizational learning]. , 2001, Revista de enfermeria.

[69]  Zvi Griliches,et al.  Issues in Assessing the Contribution of Research and Development to Productivity Growth , 1979 .

[70]  R. Katila,et al.  Where do resources come from? The role of idiosyncratic situations , 2004 .

[71]  Daniel A. Levinthal,et al.  Exploration and Exploitation in Organizational Learning , 2007 .

[72]  G. Hamel.  Competition for competence and interpartner learning within international strategic alliances , 1991 .

[73]  D. Schendel,et al.  Strategic responses to technological threats , 1976 .

[74]  J. Hagedoorn,et al.  Measuring innovative performance: is there an advantage in using multiple indicators? , 2003 .

[75]  J. Hagedoorn,et al.  Learning in Dynamic Inter-Firm Networks: The Efficacy of Multiple Contacts , 2002 .

[76]  Dean M. Behrens,et al.  Redundant governance structures: an analysis of structural and relational embeddedness in the steel and semiconductor industries , 2000 .

[77]  S. Winter,et al.  An evolutionary theory of economic change , 1983 .

[78]  C. Edquist.  Systems of Innovation: Technologies, Institutions and Organizations , 1997 .

[79]  Bart Nooteboom,et al.  Firm Size and Efficiency in R&D Spending , 1995 .

[80]  Toby E. Stuart,et al.  A Role-Based Ecology of Technological Change , 1995, American Journal of Sociology.