A Retrospective, Long‐term Follow‐up of the Clinical Outcomes and Cost‐effectiveness of Single‐anesthetic Multiple Total Joint Procedures in Hemophilic Arthropathy

Although total joint replacement (TJR) procedures are efficacious, perioperative high‐dose factors replacement therapy (FRT) to avoid catastrophic bleeding represents a significant hurdle, particularly for patients with multiple joint affection. Double simultaneous bilateral TJRs were reported as safe and cost‐effective. However, little is known about multiple TJRs. The feasibility and effects remain debatable. Surgeons need to weigh the high cost of FRT against safety. Accordingly, we aimed to evaluate the clinical outcomes and cost‐effectiveness of single‐anesthetic multiple‐joint procedures of lower limbs in end‐stage hemophilic arthropathy.

[1]  Yi Liu,et al.  Total knee arthroplasty exhibits satisfactory long-term clinical efficacy in the treatment of hemophilia patients with stiff knees , 2023, Frontiers in Surgery.

[2]  V. Jiménez‐Yuste,et al.  Complications and Implant Survival of Total Knee Arthroplasty in People with Hemophilia , 2022, Journal of clinical medicine.

[3]  G. Kinikli,et al.  Postoperative bleeding adversely affects total knee arthroplasty outcomes in hemophilia. , 2022, The Knee.

[4]  R. Cuesta-Barriuso,et al.  Hemophilic Arthropathy: Barriers to Early Diagnosis and Management , 2022, Journal of blood medicine.

[5]  Jing-Jie Zhang,et al.  Total knee arthroplasty in patients with haemophilic arthropathy is effective and safe according to the outcomes at a mid-term follow-up , 2022, Journal of Orthopaedics and Traumatology.

[6]  Muhammet Kalkışım,et al.  The mid-term clinical outcomes of total knee arthroplasty in the management of end-stage hemophilic arthropathy , 2022, Acta orthopaedica et traumatologica turcica.

[7]  S. Wen,et al.  Acute surgical site infection after total knee arthroplasty in patients with rheumatoid arthritis versus osteoarthritis , 2021, Scientific Reports.

[8]  F. Peyvandi,et al.  Hemophilic arthropathy: Current knowledge and future perspectives , 2021, Journal of thrombosis and haemostasis : JTH.

[9]  Sang-Hak Lee,et al.  Mid-to Long-Term Survival of Total Knee Arthroplasty in Hemophilic Arthropathy , 2020, Journal of clinical medicine.

[10]  C. Cruz-Montecinos,et al.  Knee haemophilic arthropathy care in Chile: Midterm outcomes and complications after total knee arthroplasty , 2020, Haemophilia : the official journal of the World Federation of Hemophilia.

[11]  X. Weng,et al.  Hemophilic arthropathy in a patient with multi-joint replacement , 2018, Medicine.

[12]  I. Cho,et al.  Infection and revision rates following primary total knee arthroplasty in patients with rheumatoid arthritis versus osteoarthritis: a meta-analysis , 2017, Knee Surgery, Sports Traumatology, Arthroscopy.

[13]  B. Haghpanah,et al.  Simultaneous bilateral total knee arthroplasty in patients with haemophilia: a safe and cost‐effective procedure? , 2016, Haemophilia : the official journal of the World Federation of Hemophilia.

[14]  X. Weng,et al.  Perioperative Period of a Hemophilia‐related Osteoarthropathy Therapeutic Regimen and Analysis of Complications , 2016, Orthopaedic surgery.

[15]  A. Lienhart,et al.  Seventy‐two total knee arthroplasties performed in patients with haemophilia using continuous infusion , 2013, Vox sanguinis.

[16]  J. Mahlangu,et al.  Guidelines for the management of hemophilia , 2013, Haemophilia : the official journal of the World Federation of Hemophilia.

[17]  A. Forsyth,et al.  Total Knee Arthroplasty in Hemophiliacs: Gains in Range of Motion Realized beyond Twelve Months Postoperatively , 2012, Clinics in orthopedic surgery.

[18]  S. Fucentese,et al.  Haemophilic knee arthropathy: long-term outcome after total knee replacement , 2012, Knee Surgery, Sports Traumatology, Arthroscopy.

[19]  S. Liew,et al.  Clinical outcomes and patient satisfaction following total joint replacement in haemophilia – 23‐year experience in knees, hips and elbows , 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

[20]  P. Mannucci,et al.  Factors influencing the long‐term outcome of primary total knee replacement in haemophiliacs: a review of 116 procedures at a single institution , 2009, British journal of haematology.

[21]  E. Rodríguez‐Merchán.  Ankle surgery in haemophilia with special emphasis on arthroscopic debridement , 2008, Haemophilia : the official journal of the World Federation of Hemophilia.

[22]  A. Harris,et al.  Hemophilic Arthropathy. , 2017, Orthopedics.

[23]  G. Tjønnfjord,et al.  Haemophilic arthropathy: long-term outcomes in 107 primary total knee arthroplasties. , 2014, The Knee.

[24]  J. Luck,et al.  Long-term results of primary total knee replacement in patients with hemophilia. , 2005, The Journal of bone and joint surgery. American volume.

[25]  F. Loth.  [Hemophilic arthropathy]. , 1962, Chirurgia narzadow ruchu i ortopedia polska.