CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat

[1]  Anne W. Schmidt,et al.  The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels. , 1992, European journal of pharmacology.

[2]  R. Melzack,et al.  The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[3]  Y. Koninck,et al.  Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Anne W. Schmidt,et al.  Rapid communicationThe substance P receptor antagonist CP-96,345 interacts with Ca2+ channels , 1992 .

[5]  M. Salter,et al.  Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin , 1991, Neuroscience.

[6]  K. McCarson,et al.  Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat , 1991, Brain Research.

[7]  J. Henry,et al.  Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P , 1991, Neuroscience Letters.

[8]  J. Henry,et al.  NMDA receptor antagonist blocks the facilitation of the tail flick reflex in the rat induced by intrathecal administration of substance P and by noxious cutaneous stimulation , 1991, Neuroscience Letters.

[9]  R. Quirion,et al.  Effects of dorsal rhizotomy on neurokinin receptor sub-types in the rat spinal cord: a quantitative autoradiographic study , 1991, Brain Research.

[10]  A. Larson,et al.  Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model , 1991, Pain.

[11]  A. Ganong,et al.  Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist. , 1991, Science.

[12]  J. Lowe,et al.  A potent nonpeptide antagonist of the substance P (NK1) receptor. , 1991, Science.

[13]  T. Yamamoto,et al.  Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction. , 1991, Life sciences.

[14]  T. Yaksh,et al.  Intrathecal somatostatin, somatostatin analogs, substance P analog and dynorphin A cause comparable neurotoxicity in rats , 1990, Neuroscience.

[15]  B. D. Goldstein,et al.  Changes of substance P-like immunoreactivity in the dorsal horn are associated with the ‘phasic’ behavioral response to a formalin stimulus , 1990, Brain Research.

[16]  R. Melzack,et al.  Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection , 1990, Brain Research.

[17]  C. Woolf,et al.  Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[18]  R. Inoki,et al.  Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord. , 1990, The Journal of pharmacology and experimental therapeutics.

[19]  R. Quirion,et al.  Quantitative autoradiographic distribution of multiple neurokinin binding sites in rat spinal cord , 1990, Brain Research.

[20]  H. Takagi,et al.  Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ , 1989, Neuroscience.

[21]  R. Inoki,et al.  Modified formalin test: characteristic biphasic pain response , 1989, Pain.

[22]  J. Henry,et al.  Facilitation of the tail-flick reflex by noxious cutaneous stimulation in the rat: antagonism by a substance P analogue , 1988, Brain Research.

[23]  M. Salter,et al.  Tachykinins enhance the depression of spinal nociceptive neurons caused by cutaneously applied vibration in the cat , 1988, Neuroscience.

[24]  J. Rochford,et al.  Lack of effect of adrenal denervation on analgesia elicited by continous and intermittent cold water swim in the rat , 1988, Brain Research.

[25]  M. Salter,et al.  Purine-induced depression of dorsal horn neurons in the cat spinal cord: Enhancement by tachykinins , 1987, Neuroscience.

[26]  V. Go,et al.  Release of substance P from the cat spinal cord. , 1987, The Journal of physiology.

[27]  Kjell Hole,et al.  The formalin test in mice: dissociation between inflammatory and non-inflammatory pain , 1987, Pain.

[28]  U. Ungerstedt,et al.  In vivo release of substance P in cat dorsal horn studied with microdialysis , 1987, Neuroscience Letters.

[29]  S. Gauthier,et al.  Distribution of label after intrathecal administration of 125I-substance P in the rat , 1987, Peptides.

[30]  I. Hendry,et al.  Noxious heating of the skin releases immunoreactive substance P in the substantia gelatinosa of the cat: A study with antibody microprobes , 1987, Brain Research.

[31]  J. Henry,et al.  Substance P given intrathecally at the spinal T9 level increases arterial pressure and heart rate in the rat. , 1987, Journal of the autonomic nervous system.

[32]  E. Perl,et al.  Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. , 1986, Science.

[33]  J. Henry,et al.  Comparison of the effects of substance P, neurokinin A, physalaemin and eledoisin in facilitating a nociceptive reflex in the rat , 1986, Brain Research.

[34]  S. Gauthier,et al.  Substance P given intrathecally at the spinal T9 level increases adrenal output of adrenaline and noradrenaline in the rat , 1985, Neuroscience.

[35]  E. Escher,et al.  Characterization of spinal actions of four substance P analogues. , 1985, European journal of pharmacology.

[36]  J. Henry,et al.  Substance p anatogue blocks sp-induced facilitation of a spinal nociceptive reflex , 1984, Brain Research Bulletin.

[37]  R. Melzack,et al.  Unilateral analgesia produced by intraventricular morphine , 1984, Brain Research.

[38]  R. Melzack,et al.  Effects of peripheral antisympathetic treatments in the tail-flick, formalin and autotomy tests , 1984, Pain.

[39]  T. O'donohue,et al.  Autoradiographic distribution of substance P receptors in rat central nervous system , 1983, Nature.

[40]  J. Henry,et al.  Endorphins mediate overshoot of substance P-induced facilitation of a spinal nociceptive reflex. , 1983, Canadian journal of physiology and pharmacology.

[41]  J. Henry,et al.  Substance P reduces tail-flick latency: Implications for chronic pain syndromes , 1982, Pain.

[42]  A. Cuello,et al.  Depletion of substance P-containing axons in substantia gelatinosa of patients with diminished pain sensitivity , 1982, Nature.

[43]  M. Piercey,et al.  Sensory and motor functions of spinal cord substance P. , 1981, Science.

[44]  J. Henry,et al.  Design for an inexpensive unit for measuring tail flick latencies. , 1981, Journal of pharmacological methods.

[45]  T. Jessell,et al.  Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo , 1980, Nature.

[46]  B. Sessle,et al.  Effects of substance P on nociceptive and non-nociceptive trigeminal brain stem neurons , 1980, PAIN.

[47]  E. Perl,et al.  Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers , 1979, The Journal of comparative neurology.

[48]  Elizabeth Theriault,et al.  Capsaicin-evoked release of substance P from primary sensory neurons , 1979, Brain Research.

[49]  I. Kanazawa,et al.  The distribution of substance P immunoreactive fibers in the rat central nervous system , 1978, The Journal of comparative neurology.

[50]  D. Dubuisson,et al.  The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats , 1977, Pain.

[51]  I. Kanazawa,et al.  Substance P: localization in synaptic vesicles in rat central nervous system , 1977, Journal of neurochemistry.

[52]  L. Iversen,et al.  Opiate analgesics inhibit substance P release from rat trigeminal nucleus , 1977, Nature.

[53]  Robert Elde,et al.  Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P , 1977 .

[54]  J. Henry,et al.  Effects of substance P on functionally identified units in cat spinal cord , 1976, Brain Research.

[55]  T. Hökfelt,et al.  Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons , 1975, Brain Research.

[56]  G. Nilsson,et al.  Substance p: localization in the central nervous system and in some primary sensory neurons , 1975, Science.

[57]  K. Krnjević,et al.  Substance P and spinal neurones. , 1975, Canadian journal of physiology and pharmacology.

[58]  Tomoyuki Takahashi,et al.  Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root section , 1975, Brain Research.

[59]  H. E. Torebjörk,et al.  Afferent C units responding to mechanical, thermal and chemical stimuli in human non-glabrous skin. , 1974, Acta physiologica Scandinavica.

[60]  J. L. Myers Fundamentals of Experimental Design , 1972 .