CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat
暂无分享,去创建一个
[1] Anne W. Schmidt,et al. The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels. , 1992, European journal of pharmacology.
[2] R. Melzack,et al. The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[3] Y. Koninck,et al. Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[4] Anne W. Schmidt,et al. Rapid communicationThe substance P receptor antagonist CP-96,345 interacts with Ca2+ channels , 1992 .
[5] M. Salter,et al. Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin , 1991, Neuroscience.
[6] K. McCarson,et al. Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat , 1991, Brain Research.
[7] J. Henry,et al. Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P , 1991, Neuroscience Letters.
[8] J. Henry,et al. NMDA receptor antagonist blocks the facilitation of the tail flick reflex in the rat induced by intrathecal administration of substance P and by noxious cutaneous stimulation , 1991, Neuroscience Letters.
[9] R. Quirion,et al. Effects of dorsal rhizotomy on neurokinin receptor sub-types in the rat spinal cord: a quantitative autoradiographic study , 1991, Brain Research.
[10] A. Larson,et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model , 1991, Pain.
[11] A. Ganong,et al. Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist. , 1991, Science.
[12] J. Lowe,et al. A potent nonpeptide antagonist of the substance P (NK1) receptor. , 1991, Science.
[13] T. Yamamoto,et al. Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction. , 1991, Life sciences.
[14] T. Yaksh,et al. Intrathecal somatostatin, somatostatin analogs, substance P analog and dynorphin A cause comparable neurotoxicity in rats , 1990, Neuroscience.
[15] B. D. Goldstein,et al. Changes of substance P-like immunoreactivity in the dorsal horn are associated with the ‘phasic’ behavioral response to a formalin stimulus , 1990, Brain Research.
[16] R. Melzack,et al. Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection , 1990, Brain Research.
[17] C. Woolf,et al. Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[18] R. Inoki,et al. Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord. , 1990, The Journal of pharmacology and experimental therapeutics.
[19] R. Quirion,et al. Quantitative autoradiographic distribution of multiple neurokinin binding sites in rat spinal cord , 1990, Brain Research.
[20] H. Takagi,et al. Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ , 1989, Neuroscience.
[21] R. Inoki,et al. Modified formalin test: characteristic biphasic pain response , 1989, Pain.
[22] J. Henry,et al. Facilitation of the tail-flick reflex by noxious cutaneous stimulation in the rat: antagonism by a substance P analogue , 1988, Brain Research.
[23] M. Salter,et al. Tachykinins enhance the depression of spinal nociceptive neurons caused by cutaneously applied vibration in the cat , 1988, Neuroscience.
[24] J. Rochford,et al. Lack of effect of adrenal denervation on analgesia elicited by continous and intermittent cold water swim in the rat , 1988, Brain Research.
[25] M. Salter,et al. Purine-induced depression of dorsal horn neurons in the cat spinal cord: Enhancement by tachykinins , 1987, Neuroscience.
[26] V. Go,et al. Release of substance P from the cat spinal cord. , 1987, The Journal of physiology.
[27] Kjell Hole,et al. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain , 1987, Pain.
[28] U. Ungerstedt,et al. In vivo release of substance P in cat dorsal horn studied with microdialysis , 1987, Neuroscience Letters.
[29] S. Gauthier,et al. Distribution of label after intrathecal administration of 125I-substance P in the rat , 1987, Peptides.
[30] I. Hendry,et al. Noxious heating of the skin releases immunoreactive substance P in the substantia gelatinosa of the cat: A study with antibody microprobes , 1987, Brain Research.
[31] J. Henry,et al. Substance P given intrathecally at the spinal T9 level increases arterial pressure and heart rate in the rat. , 1987, Journal of the autonomic nervous system.
[32] E. Perl,et al. Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. , 1986, Science.
[33] J. Henry,et al. Comparison of the effects of substance P, neurokinin A, physalaemin and eledoisin in facilitating a nociceptive reflex in the rat , 1986, Brain Research.
[34] S. Gauthier,et al. Substance P given intrathecally at the spinal T9 level increases adrenal output of adrenaline and noradrenaline in the rat , 1985, Neuroscience.
[35] E. Escher,et al. Characterization of spinal actions of four substance P analogues. , 1985, European journal of pharmacology.
[36] J. Henry,et al. Substance p anatogue blocks sp-induced facilitation of a spinal nociceptive reflex , 1984, Brain Research Bulletin.
[37] R. Melzack,et al. Unilateral analgesia produced by intraventricular morphine , 1984, Brain Research.
[38] R. Melzack,et al. Effects of peripheral antisympathetic treatments in the tail-flick, formalin and autotomy tests , 1984, Pain.
[39] T. O'donohue,et al. Autoradiographic distribution of substance P receptors in rat central nervous system , 1983, Nature.
[40] J. Henry,et al. Endorphins mediate overshoot of substance P-induced facilitation of a spinal nociceptive reflex. , 1983, Canadian journal of physiology and pharmacology.
[41] J. Henry,et al. Substance P reduces tail-flick latency: Implications for chronic pain syndromes , 1982, Pain.
[42] A. Cuello,et al. Depletion of substance P-containing axons in substantia gelatinosa of patients with diminished pain sensitivity , 1982, Nature.
[43] M. Piercey,et al. Sensory and motor functions of spinal cord substance P. , 1981, Science.
[44] J. Henry,et al. Design for an inexpensive unit for measuring tail flick latencies. , 1981, Journal of pharmacological methods.
[45] T. Jessell,et al. Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo , 1980, Nature.
[46] B. Sessle,et al. Effects of substance P on nociceptive and non-nociceptive trigeminal brain stem neurons , 1980, PAIN.
[47] E. Perl,et al. Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers , 1979, The Journal of comparative neurology.
[48] Elizabeth Theriault,et al. Capsaicin-evoked release of substance P from primary sensory neurons , 1979, Brain Research.
[49] I. Kanazawa,et al. The distribution of substance P immunoreactive fibers in the rat central nervous system , 1978, The Journal of comparative neurology.
[50] D. Dubuisson,et al. The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats , 1977, Pain.
[51] I. Kanazawa,et al. Substance P: localization in synaptic vesicles in rat central nervous system , 1977, Journal of neurochemistry.
[52] L. Iversen,et al. Opiate analgesics inhibit substance P release from rat trigeminal nucleus , 1977, Nature.
[53] Robert Elde,et al. Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P , 1977 .
[54] J. Henry,et al. Effects of substance P on functionally identified units in cat spinal cord , 1976, Brain Research.
[55] T. Hökfelt,et al. Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons , 1975, Brain Research.
[56] G. Nilsson,et al. Substance p: localization in the central nervous system and in some primary sensory neurons , 1975, Science.
[57] K. Krnjević,et al. Substance P and spinal neurones. , 1975, Canadian journal of physiology and pharmacology.
[58] Tomoyuki Takahashi,et al. Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root section , 1975, Brain Research.
[59] H. E. Torebjörk,et al. Afferent C units responding to mechanical, thermal and chemical stimuli in human non-glabrous skin. , 1974, Acta physiologica Scandinavica.
[60] J. L. Myers. Fundamentals of Experimental Design , 1972 .