Tool-use learning induces BDNF expression in a selective portion of monkey anterior parietal cortex.

Learning but not execution of tool-use induced expression of brain-derived neurotrophic factor (BDNF). The expression was highest in the anterior bank of the intraparietal sulcus, especially in the region posteriorly adjacent to the somatosensory shoulder and forearm region in area 3b, suggesting that BDNF plays a role in altering the body image of the hand to include the repeatedly used tool as its extension.

[1]  A. Iriki,et al.  Tool-use learning selectively induces expression of brain-derived neurotrophic factor, its receptor trkB, and neurotrophin 3 in the intraparietal multisensorycortex of monkeys. , 2002, Brain research. Cognitive brain research.

[2]  A. Iriki,et al.  Acquisition and development of monkey tool-use: behavioral and kinematic analyses. , 2000, Canadian journal of physiology and pharmacology.

[3]  D. Pandya,et al.  Converging visual and somatic sensory cortical input to the intraparietal sulcus of the rhesus monkey , 1980, Brain Research.

[4]  S. Obayashi,et al.  Subjective image of invisible hand coded by monkey intraparietal neurons , 2000, Neuroreport.

[5]  Mu-ming Poo,et al.  Neurotrophins as synaptic modulators , 2001, Nature Reviews Neuroscience.

[6]  A. Yamashita,et al.  Expression of GAP-43 and SCG10 mRNAs in Lateral Geniculate Nucleus of Normal and Monocularly Deprived Macaque Monkeys , 2000, The Journal of Neuroscience.

[7]  H. Onoe,et al.  Functional Brain Mapping of Monkey Tool Use , 2001, NeuroImage.

[8]  M. Tanaka,et al.  Coding of modified body schema during tool use by macaque postcentral neurones. , 1996, Neuroreport.

[9]  Leslie G. Ungerleider,et al.  Organization of visual inputs to the inferior temporal and posterior parietal cortex in macaques , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[10]  J. Moll,et al.  Functional MRI correlates of real and imagined tool-use pantomimes , 2000, Neurology.

[11]  M. Goodale,et al.  Active manual control of object views facilitates visual recognition , 1999, Current Biology.

[12]  Y. Iwamura.  Hierarchical somatosensory processing , 1998, Current Opinion in Neurobiology.

[13]  Y Miyashita,et al.  Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito‐temporo‐hippocampal pathway in adult macaque monkeys , 1999, The Journal of comparative neurology.

[14]  Atsushi Iriki,et al.  Self-images in the video monitor coded by monkey intraparietal neurons , 2001, Neuroscience Research.

[15]  S. Aglioti,et al.  The body in the brain: neural bases of corporeal awareness , 1997, Trends in Neurosciences.