DTPA therapy of 241Am from a simulated wound site.

The results of an investigation to determine the effect of daily injections over a period of 10 weeks of Zn-DTPA on the distribution of $sup 241$Am from a simulated wound site on the carpal pad of beagles are reported. It is shown that daily injections of Zn-DTPA hastened the disappearance of $sup 241$Am from the simulated wound site, prevented almost completely the translocation from the depot to the liver and skeleton, and reduced significantly the total body $sup 241$Am content through increased excretion. Dividing the daily total administration of Zn-DTPA into five equal fractions given at about 5- hr intervals seemed to increase somewhat the effectiveness of this chelating agent relative to the administration of the same daily total given in a single injection each day. (UK)