Neuropharmacological Modeling, Pharmacogenomics and Ion Channel Modulation

Ion channels are both the primary cause of excitability disorders (e.g., epilepsy; myotonia; cardiac arrhythmia) and the principle target of many pharmaceutical compounds. Because ion channels both respond to and regulate the cellular response to stimuli, they are the dominant molecules governing excitability of neurons and networks. Computational models of drug effects and genetic mutations reveal the mechanisms underlying channel function, allowing prediction to be validated in silico and generating new hypotheses that can be tested via biological experimentation.

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