genome. Experiments performed to determine relationships between these parameters in various nutrient media are described and interpreted. After discussing steady states, attention is focused upon the very interesting work on variation of synthesis rates when bacteria are transferred from a minimal to an enriched medium. Measurement of the rates for various classes of macromolecules reveals that RNA synthesis increases immediately upon shifting to an enriched medium, while there is a lag period in the increase of protein and DNA synthesis. The implications of this observation are discussed in detail and its ramifications are elucidated with reference to additional experiments which suggest mechanisms for the control of RNA and DNA synthesis. In the closing chapter, regulation of DNA synthesis and physicochemical properties of the bacterial nucleus bearing upon the problem of control are treated. The latter discussion is particularly relevant to the problem of relationships between in zvvo and in vitro experiments. Following an extensive list of references is an appendix consisting of reprints of four original papers. This monograph is recommended to one who would acquaint himself with the most recent work and thinking in the area. The only reservation held by this reviewer is in regard to the inclusion of a lengthy appendix of four reprints from journals available in any well-stocked library. This bibliography fulfills, certainly with respect to the entity, sarcoidosis, a significant need in view of the immense literature that has been written concerning it. It is most complete and the method of subdivision of the bibliography in terms of those specific aspects related to sarcoidosis is done in a very logical manner. This type of work is indeed of value as a time saver for all interested in undertaking literature review. This volume presents the complete proceedings of a conference held in April 1965, attended by some 60 continental experts on the mitochondrion. Modern analysis of mitochondria began roughly 20 years ago. After techniques for isolating these organelles from tissues became available, the mitochondria were found to contain enzymes for the tricarboxylic acid cycle, for oxidation of fatty acids, and for the complex process of "oxidative phosphorylation." Ten years or so later, the electron microscopists were able to visualize the inner details of mitochondrial structure. With these 137