Complete Genome Sequence of a J Subgroup Avian Leukosis Virus Isolated from Local Commercial Broilers

ABSTRACT Subgroup J avian leukosis virus (ALV-J) isolate GDKP1202 was isolated from a 50-day-old local yellow commercial broiler in the Guangdong province of China in 2012. Here we report the complete genomic sequence of the GDKP1202 isolate, which caused high mortality, serious growth suppression, thymic atrophy, and liver enlargement in commercial broilers. A novel potential binding site (5′-GGCACCTCC-3′) for c-myb was identified in the GDKP1202 genome. These findings will provide additional insights into the molecular characteristics in the genomes and pathogenicity of ALV-J.

[1]  L. N. Payne,et al.  The long view: 40 years of avian leukosis research , 2012, Avian pathology : journal of the W.V.P.A.

[2]  Xiaomei Wang,et al.  Molecular Epidemiology of Avian Leukosis Virus Subgroup J in Layer Flocks in China , 2011, Journal of Clinical Microbiology.

[3]  Xiaomei Wang,et al.  Novel sequences of subgroup J avian leukosis viruses associated with hemangioma in Chinese layer hens , 2011, Virology Journal.

[4]  Z. Cui,et al.  Simultaneous endemic infections with subgroup J avian leukosis virus and reticuloendotheliosis virus in commercial and local breeds of chickens , 2009, Avian pathology : journal of the W.V.P.A.

[5]  Cui Zhi-zhong.  Clone and Sequencing of gp37 of Subgroup J Avian Leukosis Viruses in China , 2003 .

[6]  T. Nagase,et al.  c-Myb Repression of c- erbB-2 Transcription by Direct Binding to the c- erbB-2 Promoter (*) , 1995, The Journal of Biological Chemistry.

[7]  J. Bai,et al.  HPRS-103 (exogenous avian leukosis virus, subgroup J) has an env gene related to those of endogenous elements EAV-0 and E51 and an E element found previously only in sarcoma viruses , 1995, Journal of virology.

[8]  A. Ruddell.  Transcription regulatory elements of the avian retroviral long terminal repeat. , 1995, Virology.

[9]  B. Calabretta,et al.  Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene , 1991, Molecular and cellular biology.

[10]  T. Nagase,et al.  Binding of the c-myb proto-oncogene product to the simian virus 40 enhancer stimulates transcription. , 1990, The Journal of biological chemistry.