Front‐line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma

The conventional treatment of brain metastases not amenable to surgery is most often radiotherapy. Until now, pharmacologic issues related to the blood brain barrier (BBB) prevented a wide evaluation of chemotherapy. The authors previously reported that the combination of cisplatin (P) and etoposide (E) had strikingly high activity in patients with brain metastases from breast carcinoma. The purpose of this study was to assess, in a larger prospective study, the front‐line activity of that combination against brain metastases from breast carcinoma (BC), nonsmall cell lung carcinoma (NSCLC), and malignant melanoma (MM) in patients previously untreated with radiotherapy.

[1]  J. Wolchok,et al.  Systemic chemotherapy. , 2000, Clinics in plastic surgery.

[2]  F. Lohr,et al.  Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[3]  L. Crinò,et al.  Chemotherapy with cisplatin and teniposide for cerebral metastases in non-small cell lung cancer. , 1998, Lung cancer.

[4]  U. Nestle,et al.  Dose/effect relationships for brain metastases , 1998, Journal of Cancer Research and Clinical Oncology.

[5]  C. Nieder,et al.  Tumor-related prognostic factors for remission of brain metastases after radiotherapy. , 1997, International journal of radiation oncology, biology, physics.

[6]  L Gaspar,et al.  Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. , 1997, International journal of radiation oncology, biology, physics.

[7]  A. Santini,et al.  Response of brain metastases from lung cancer to systemic chemotherapy with carboplatin and etoposide. , 1996, Oncology.

[8]  J. Dunn,et al.  Final results of the Royal College of Radiologists' trial comparing two different radiotherapy schedules in the treatment of cerebral metastases. , 1996, Clinical oncology (Royal College of Radiologists (Great Britain)).

[9]  G. Cocconi,et al.  Cisplatin and VP16 in Metastatic Breast Carcinoma as a Third-Line Chemotherapy: A Randomized Study Comparing Low versus High Doses of Cisplatin , 1995, Tumori.

[10]  L. Crinò,et al.  Chemotherapy of advanced non-small-cell lung cancer: a comparison of three active regimens. A randomized trial of the Italian Oncology Group for Clinical Research (G.O.I.R.C.). , 1995, Annals of oncology : official journal of the European Society for Medical Oncology.

[11]  G. Giaccone,et al.  Teniposide for brain metastases of small-cell lung cancer: a phase II study. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[12]  D. Ball,et al.  Treatment of brain metastases from primary lung cancer. , 1995, International journal of radiation oncology, biology, physics.

[13]  L. Crinò.  Chemotherapy in advanced non-small-cell lung cancer. The experience of Italian Cooperative Groups. , 1995, Annals of oncology : official journal of the European Society for Medical Oncology.

[14]  Craig R. Nichols.  Management of Central Nervous System Metastases in Patients with Disseminated Germ Cell Tumours , 1994 .

[15]  L. Crinò,et al.  Cisplatin (CDDP)-etoposide VS DCCP-mitomycin-vindesine VS CDDP-mitomycin-iphosphamide in advanced non small cell lung cancer (NSCLC). A prospective randomized trial of the Italian oncology group for clinical research. (GOIRC) , 1993 .

[16]  O. Dalesio,et al.  Response of brain metastases from breast cancer to systemic chemotherapy , 1992, Cancer.

[17]  C. Boni,et al.  Cisplatin and etoposide as first-line chemotherapy for metastatic breast carcinoma: a prospective randomized trial of the Italian Oncology Group for Clinical Research. , 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  C. Pona,et al.  Lung Cancer with a Single Brain Metastasis: Therapeutic Options , 1990, Tumori.

[19]  C. Boni,et al.  Combination therapy with platinum and etoposide of brain metastases from breast carcinoma. , 1990, Cancer investigation.

[20]  N. Greig.  Brain Tumors and the Blood-Tumor Barrier , 1989 .

[21]  E. Neuwelt,et al.  Implications of the Blood-Brain Barrier and Its Manipulation , 1989, Springer US.

[22]  Goldie Jh,et al.  Interaction of etoposide and cisplatin in an in vitro tumor model. , 1987 .

[23]  J H Goldie,et al.  Interaction of etoposide and cisplatin in an in vitro tumor model. , 1987, Cancer treatment reports.

[24]  W. Lane,et al.  Chemotherapy induces regression of brain metastases in breast carcinoma , 1986, Cancer.

[25]  R. F. Ryan,et al.  Cutaneous melanoma : clinical management and treatment results worldwide , 1986 .

[26]  N. Greig,et al.  Chemotherapy of brain metastases: current status. , 1984, Cancer treatment reviews.

[27]  R. Caprioli,et al.  Human central nervous system distribution of cis-diamminedichloroplatinum and use as a radiosensitizer in malignant brain tumors. , 1982, Cancer research.

[28]  R. Gelber,et al.  Equivalence of radiation schedules for the palliative treatment of brain metastases in patients with favorable prognosis , 1981, Cancer.

[29]  A. Miller,et al.  Reporting results of cancer treatment , 1981, Cancer.

[30]  R. Benjamin,et al.  Penetration of N-(phosphonacetyl)-L-aspartate into human central nervous system and intracerebral tumor. , 1980, Cancer research.

[31]  W. Shapiro.  Chemotherapy of Metastatic Central Nervous System Carcinoma , 1980 .

[32]  G. Hortobagyi,et al.  The natural history of breast cancer patients with brain metastases , 1979, Cancer.

[33]  Posner Jb.  Management of central nervous system metastases. , 1977, Seminars in oncology.

[34]  J. Posner.  Management of central nervous system metastases. , 1977, Seminars in oncology.

[35]  E. Boldrey,et al.  Single-agent chemotherapy of brain tumors. A five-year review. , 1976, Archives of neurology.

[36]  T E Walsh,et al.  Reporting results. , 1969, Archives of otolaryngology.

[37]  B. W. Lichtenstein,et al.  Neoplasms in the nervous system. , 1949 .

[38]  A. Satterfield,et al.  TREATMENT , 1924, California and western medicine.