Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences.

BACKGROUND Procaine activates limbic structures in animals. In humans, acute intravenous administration of procaine yields emotional and psychosensory experiences and temporal lobe fast activity. We studied procaine's acute effects on cerebral blood flow (CBF) in relationship to clinical responses. METHODS Cerebral blood flow was assessed by positron emission tomography with oxygen-15-labeled water in 32 healthy volunteers. Data were analyzed with statistical parametric mapping and magnetic resonance imaging-directed regions of interest. RESULTS Procaine increased global CBF and, to a greater extent, anterior paralimbic CBF. Subjects with intense procaine-induced fear compared with those with euphoria had greater increases in left amygdalar CBF. Absolute and normalized left amygdalar CBF changes tended to correlate positively with fear and negatively with euphoria intensity. Procaine-induced visual hallucinations appeared associated with greater global and occipital CBF increases. Absolute occipital CBF increases appeared to correlate positively with visual hallucination intensity. CONCLUSIONS Procaine increased anterior paralimbic CBF, and different clinical responses appeared to be associated with different patterns of CBF changes.

[1]  A. Shekhar,et al.  Anxiolytic effects of chlordiazepoxide blocked by injection of GABAA and benzodiazepine receptor antagonists in the region of the anterior basolateral amygdala of rats , 1995, Biological Psychiatry.

[2]  N. Alpert,et al.  A positron emission tomographic study of simple phobic symptom provocation. , 1995, Archives of general psychiatry.

[3]  R. Adamec,et al.  The effect of kindling of different nuclei in the left and right amygdala on anxiety in the rat , 1994, Physiology & Behavior.

[4]  J. Changeux,et al.  Allosteric modulations of the nicotinic acetylcholine receptor , 1993, Trends in Neurosciences.

[5]  L. Abood,et al.  Affinity ligands and related agents for brain muscarinic and nicotinic cholinergic receptors. , 1993, Biochemical Pharmacology.

[6]  D. DeHaven-Hudkins,et al.  Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography. , 1993, Journal of medicinal chemistry.

[7]  Linda J. Porrino,et al.  Cortical Mechanisms of Reinforcement , 1993 .

[8]  B. Vogt,et al.  Connections of the Monkey Cingulate Cortex , 1993 .

[9]  Brent A. Vogt,et al.  Structural Organization of Cingulate Cortex: Areas, Neurons, and Somatodendritic Transmitter Receptors , 1993 .

[10]  O. Devinsky,et al.  The Contributions of Cingulate Cortex to Human Behavior , 1993 .

[11]  C. Olson,et al.  Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. , 1992, Cerebral cortex.

[12]  J. Mazziotta,et al.  Rapid Automated Algorithm for Aligning and Reslicing PET Images , 1992, Journal of computer assisted tomography.

[13]  Changiz Geula,et al.  Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: A choline acetyltransferase study , 1992, The Journal of comparative neurology.

[14]  H. C. Moises,et al.  Muscarinic responses of rat basolateral amygdaloid neurons recorded in vitro. , 1992, The Journal of physiology.

[15]  L. Hersh,et al.  The basal forebrain cholinergic system: efferent and afferent connectivity and long‐term effects of lesions , 1991, Acta psychiatrica Scandinavica. Supplementum.

[16]  Karl J. Friston,et al.  Comparing Functional (PET) Images: The Assessment of Significant Change , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[17]  A. Wilson,et al.  In vivo biodistribution of two [18F]-labelled muscarinic cholinergic receptor ligands: 2-[18F]- and 4-[18F]-fluorodexetimide. , 1991, Life sciences.

[18]  Karl J. Friston,et al.  The Relationship between Global and Local Changes in PET Scans , 1990, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[19]  J M Links,et al.  Cocaine-induced reduction of glucose utilization in human brain. A study using positron emission tomography and [fluorine 18]-fluorodeoxyglucose. , 1990, Archives of general psychiatry.

[20]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[21]  Karl J. Friston,et al.  Localisation in PET Images: Direct Fitting of the Intercommissural (AC—PC) Line , 1989, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  I. Takayanagi,et al.  Interaction of 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride, ryanodine and procaine with muscarinic cholinergic M2 receptor sites in smooth muscle. , 1989, The Journal of pharmacology and experimental therapeutics.

[23]  C. Geula,et al.  Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase , 1988, The Journal of comparative neurology.

[24]  R. T. Jackson,et al.  Effects of Lidocaine and Procaine on Canine Nasal Blood Vessels , 1988, The Annals of otology, rhinology, and laryngology.

[25]  D. Cain,et al.  Retardation of amygdala kindling by antagonism of NMD-aspartate and muscarinic cholinergic receptors: Evidence for the summation of excitatory mechanisms in kindling , 1988, Experimental Neurology.

[26]  R. Adamec,et al.  The effects of procaine HCL on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits , 1987, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[27]  M. Mesulam.  Lidocaine toxicity and the limbic system. , 1987, The American journal of psychiatry.

[28]  R. Coppola,et al.  Intravenous procaine as a probe of limbic system activity in psychiatric patients and normal controls , 1987, Biological Psychiatry.

[29]  P. Worley,et al.  Site of anticonvulsant action on sodium channels: autoradiographic and electrophysiological studies in rat brain. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[30]  D. Cain,et al.  Effects of treatment with scopolamine and naloxone, singly and in combination, on amygdala kindling , 1987, Experimental Neurology.

[31]  S. Saravay,et al.  "Doom anxiety" and delirium in lidocaine toxicity. , 1987, American Journal of Psychiatry.

[32]  M. E. Corcoran,et al.  Antagonism of central but not peripheral cholinergic receptors retards amygdala kindling in rats , 1987, Experimental Neurology.

[33]  D. Scott.  Toxic effects of local anaesthetic agents on the central nervous system. , 1986, British journal of anaesthesia.

[34]  M. E. Lewis,et al.  Correlation of [3H]diazepam binding density with anxiolytic locus in the amygdaloid complex of the rat , 1985, Brain Research.

[35]  R A Koeppe,et al.  Performance Comparison of Parameter Estimation Techniques for the Quantitation of Local Cerebral Blood Flow by Dynamic Positron Computed Tomography , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[36]  R. Post,et al.  Transient Sensory, Cognitive and Affective Phenomena in Affective Illness , 1985, British Journal of Psychiatry.

[37]  D. Ingvar,et al.  Metabolic and behavioral consequences of lidocaine-kindled seizures , 1984, Brain Research.

[38]  M. Nakazawa,et al.  Effects of procaine on the isolated dog coronary artery. , 1984, Archives internationales de pharmacodynamie et de therapie.

[39]  B. Larsson,et al.  Local anaesthetics and tinnitus. Proposed peripheral mechanism of action of lidocaine. , 1984, ORL; journal for oto-rhino-laryngology and its related specialties.

[40]  L. Duckert,et al.  Treatment of tinnitus with intravenous lidocaine: A double-blind randomized trial , 1983, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[41]  D. Cain.  Bidirectional transfer of electrical and carbachol kindling , 1983, Brain Research.

[42]  P. Gloor,et al.  The role of the limbic system in experiential phenomena of temporal lobe epilepsy , 1982, Annals of neurology.

[43]  W. Burnham,et al.  Power spectral analysis of EEG drug response in the kindled rat brain. , 1981, Electroencephalography and clinical neurophysiology.

[44]  D. Greenblatt,et al.  Neuropsychiatric sequelae of pharmacotherapy of cardiac arrhythmias and hypertension. , 1981, Journal of clinical psychopharmacology.

[45]  B. Altura,et al.  PERIVASCULAR ACTION OF THE LOCAL ANAESTHETIC, LIDOCAINE, ON PIAL TERMINAL ARTERIOLES: DIRECT OBSERVATIONS ON THE MICROCIRCULATION , 1981, British Journal of Pharmacology.

[46]  J. Franco,et al.  Constriction of human umbilical artery induced by local anesthetics. , 1981, Gynecologic and obstetric investigation.

[47]  T. Babb,et al.  Procaine-induced seizures in epileptic monkeys with bilateral hippocampal foci. , 1979, Electroencephalography and clinical neurophysiology.

[48]  R. Racine,et al.  The effect of procaine hydrochloride and diazepam, separately or in combination, on cortico-generalized kindled seizures. , 1979, Electroencephalography and clinical neurophysiology.

[49]  J. Endicott,et al.  A diagnostic interview: the schedule for affective disorders and schizophrenia. , 1978, Archives of general psychiatry.

[50]  E. Halgren,et al.  Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala. , 1978, Brain : a journal of neurology.

[51]  J. V. Van Buren,et al.  Functional representation on the medial aspect of the frontal lobes in man. , 1976, Journal of neurosurgery.

[52]  R. Racine,et al.  Effects of procaine hydrochloride, diazepam, and diphenylhydantoin on seizure development in cortical and subcortical structures in rats. , 1975, Electroencephalography and clinical neurophysiology.

[53]  B. Altura,et al.  Effects of local anesthetics, antihistamines, and glucocorticoids on peripheral blood flow and vascular smooth muscle. , 1974 .

[54]  W. Keatinge,et al.  EFFECTS OF PROCAINE AND LIGNOCAINE ON ELECTRICAL AND MECHANICAL ACTIVITY OF SMOOTH MUSCLE OF SHEEP CAROTID ARTERIES , 1974, British journal of pharmacology.

[55]  R. Racine,et al.  Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat. , 1973, Experimental neurology.

[56]  J. Talairach,et al.  The cingulate gyrus and human behaviour. , 1973, Electroencephalography and clinical neurophysiology.

[57]  M. Gutnick,et al.  Local Anesthetic Drug‐Induced Seizures in Rhesus Monkeys , 1970, Anesthesia and analgesia.

[58]  G. V. Goddard.  Analysis of avoidance conditioning following cholinergic stimulation of amygdala in rats. , 1969, Journal of comparative and physiological psychology.

[59]  S. Saravay,et al.  Auditory elementary hallucinations in alcohol withdrawal psychosis. , 1967, Archives of General Psychiatry.

[60]  D. Prince,et al.  Effects of lidocaine on the central nervous system. , 1967, Anesthesiology.

[61]  Michiyo Yamasaki,et al.  Blocking of Cortical Inhibitory Synapses by Intravenous Lidocaine , 1966, Nature.

[62]  W. Lewin,et al.  Effects of anterior cingulate stimulation in conscious human subjects. , 1960, Journal of neurophysiology.

[63]  Zipf Hf.  General effects of local anesthetics , 1957 .

[64]  P. Scheinberg,et al.  Studies of cerebral circulatory functions following intravenous administration of procaine hydrochloride. , 1952, A.M.A. archives of neurology and psychiatry.

[65]  J. W. Papez.  A PROPOSED MECHANISM OF EMOTION , 1937 .