Virtual and Augmented Medical Imaging Environments: Enabling Technology for Minimally Invasive Cardiac Interventional Guidance

Virtual and augmented reality environments have been adopted in medicine as a means to enhance the clinician's view of the anatomy and facilitate the performance of minimally invasive procedures. Their value is truly appreciated during interventions where the surgeon cannot directly visualize the targets to be treated, such as during cardiac procedures performed on the beating heart. These environments must accurately represent the real surgical field and require seamless integration of pre- and intra-operative imaging, surgical tracking, and visualization technology in a common framework centered around the patient. This review begins with an overview of minimally invasive cardiac interventions, describes the architecture of a typical surgical guidance platform including imaging, tracking, registration and visualization, highlights both clinical and engineering accuracy limitations in cardiac image guidance, and discusses the translation of the work from the laboratory into the operating room together with typically encountered challenges.

[1]  Terry M. Peters,et al.  Validation of four-dimensional ultrasound for targeting in minimally-invasive beating-heart surgery , 2009, Medical Imaging.

[2]  G. Schuler,et al.  Dyna-CT during minimally invasive off-pump transapical aortic valve implantation. , 2009, The Annals of thoracic surgery.

[3]  O. Dossel,et al.  Segmentation of 4D Cardiac Images: Investigation on Statistical Shape Models , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[4]  Jing Ren,et al.  Dynamic 2D Ultrasound and 3D CT Image Registration of the Beating Heart , 2009, IEEE Transactions on Medical Imaging.

[5]  Nassir Navab,et al.  Visualization and GPU-accelerated simulation of medical ultrasound from CT images , 2009, Comput. Methods Programs Biomed..

[6]  L. Thurfjell,et al.  Image registration: an essential tool for nuclear medicine , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[7]  Jannick P. Rolland,et al.  Augmented Reality for Teaching Endotracheal Intubation: MR Imaging to Create Anatomically Correct Models , 2003, AMIA.

[8]  Wolfgang Birkfellner,et al.  Development of the Varioscope AR. A see-through HMD for computer-aided surgery , 2000, Proceedings IEEE and ACM International Symposium on Augmented Reality (ISAR 2000).

[9]  Bernd Hamm,et al.  Triage of patients with suspected coronary artery disease using multislice computed tomography. , 2007, Academic radiology.

[10]  S. Steele,et al.  The changing face of the general surgeon: national and local trends in resident operative experience. , 2010, American journal of surgery.

[11]  R D Bucholz,et al.  Variables affecting the accuracy of stereotactic localization using computerized tomography. , 1993, Journal of neurosurgery.

[12]  Masahide Kaneko,et al.  Toward the New Era of Visual Communication (Special Issue on Next Generation Visual Telecommunication and Broadcasting) , 1993 .

[13]  Peter Kellman,et al.  Real‐time accelerated interactive MRI with adaptive TSENSE and UNFOLD , 2003, Magnetic resonance in medicine.

[14]  Dieter Schmalstieg,et al.  Liver Surgery Planning Using Virtual Reality , 2006, IEEE Computer Graphics and Applications.

[15]  Jay B. West,et al.  Predicting error in rigid-body point-based registration , 1998, IEEE Transactions on Medical Imaging.

[16]  W R Hendee The information perspective of radiology. , 1992, AJR. American journal of roentgenology.

[17]  Paul J. Metzger Adding reality to the virtual , 1993, Proceedings of IEEE Virtual Reality Annual International Symposium.

[18]  Maria Drangova,et al.  Subject-specific models for image-guided cardiac surgery , 2008, Physics in medicine and biology.

[19]  A Fenster,et al.  Three-dimensional ultrasound imaging of the vasculature. , 1998, Ultrasonics.

[20]  Fabian Nietlispach,et al.  Transapical transcatheter aortic valve implantation: follow-up to 3 years. , 2010, The Journal of thoracic and cardiovascular surgery.

[21]  Christina E. Clarkson,et al.  Applications of magnetic resonance imaging for cardiac stem cell therapy. , 2004, Journal of interventional cardiology.

[22]  Robert D. Howe,et al.  Fixing the Beating Heart: Ultrasound Guidance for Robotic Intracardiac Surgery , 2009, FIMH.

[23]  Fabian Baumann,et al.  Intraoperative magnetic resonance imaging-guided transsphenoidal surgery for giant pituitary adenomas , 2009, Neurosurgical Review.

[24]  Nassir Navab,et al.  Magneto-Optical Tracking of Flexible Laparoscopic Ultrasound: Model-Based Online Detection and Correction of Magnetic Tracking Errors , 2009, IEEE Transactions on Medical Imaging.

[25]  Volkmar Falk,et al.  Transapical aortic valve implantation in 100 consecutive patients: comparison to propensity-matched conventional aortic valve replacement. , 2010, European heart journal.

[26]  Jeroen J. Bax,et al.  P on-Invasive Visualization of the Cardiac enous System in Coronary Artery Disease atients Using 64-Slice Computed Tomography , 2006 .

[27]  Shuo Li,et al.  Level Set Image Segmentation with a Statistical Overlap Constraint , 2009, IPMI.

[28]  K. Cleary,et al.  Image-guided interventions: technology review and clinical applications. , 2010, Annual review of biomedical engineering.

[29]  Heinrich Niemann,et al.  An AR system with intuitive user interface for manipulation and visualization of 3D medical data. , 2004, Studies in health technology and informatics.

[30]  D I Hoult,et al.  The engineering of an interventional MRI with a movable 1.5 Tesla magnet , 2001, Journal of magnetic resonance imaging : JMRI.

[31]  Wiro J Niessen,et al.  Quantitative Evaluation of Three Calibration Methods for 3-D Freehand Ultrasound , 2006, IEEE Transactions on Medical Imaging.

[32]  Douglas L. Jones,et al.  Mapping of Cardiac Electrophysiology Onto a Dynamic Patient-Specific Heart Model , 2009, IEEE Transactions on Medical Imaging.

[33]  Igor Klem,et al.  mproved Detection of Coronary rtery Disease by Stress Perfusion ardiovascular Magnetic Resonance With he Use of Delayed Enhancement Infarction Imaging , 2006 .

[34]  Elliot R. McVeigh,et al.  Magnetic Resonance Fluoroscopy Allows Targeted Delivery of Mesenchymal Stem Cells to Infarct Borders in Swine , 2003, Circulation.

[35]  Michael Mack,et al.  Minimally Invasive Cardiac Surgery , 2006, Surgical endoscopy.

[36]  Andrew D. Wiles,et al.  Accuracy assessment protocols for elektromagnetic tracking systems , 2003, CARS.

[37]  J. Shuhaiber,et al.  Augmented reality in surgery. , 2004, Archives of surgery.

[38]  S. Botden,et al.  What is going on in augmented reality simulation in laparoscopic surgery? , 2008, Surgical Endoscopy.

[39]  T. Peters Image-guided surgery: From X-rays to Virtual Reality , 2001, Computer methods in biomechanics and biomedical engineering.

[40]  T. Peters,et al.  On Enhancing Planning and Navigation of Beating-Heart Mitral Valve Surgery Using Pre-operative Cardiac Models , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[41]  A. Cuschieri,et al.  Task performance in endoscopic surgery is influenced by location of the image display. , 1998, Annals of surgery.

[42]  F. Sauer Image Registration: Enabling Technology for Image Guided Surgery and Therapy , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[43]  Olivier Ecabert,et al.  Automatic Intra-operative Generation of Geometric Left Atrium/Pulmonary Vein Models from Rotational X-Ray Angiography , 2008, MICCAI.

[44]  R H Taylor,et al.  System for robotically assisted percutaneous procedures with computed tomography guidance. , 2001, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[45]  Terry M. Peters,et al.  Estimating heart shift and morphological changes during minimally invasive cardiac interventions , 2010, Medical Imaging.

[46]  Terry M. Peters,et al.  Towards Subject-Specific Models of the Dynamic Heart for Image-Guided Mitral Valve Surgery , 2007, MICCAI.

[47]  Steve B Jiang,et al.  Implementation and evaluation of various demons deformable image registration algorithms on a GPU. , 2010, Physics in medicine and biology.

[48]  A Fenster,et al.  In vitro simulation and quantification of temporal jitter artifacts in ECG-gated dynamic three-dimensional echocardiography. , 2001, Ultrasound in medicine & biology.

[49]  Maria Drangova,et al.  Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony. , 2006, Journal of the American College of Cardiology.

[50]  Guang-Zhong Yang,et al.  pq-space Based Non-Photorealistic Rendering for Augmented Reality , 2007, MICCAI.

[51]  Viant Wj The development of an evaluation framework for the quantitative assessment of computer-assisted surgery and augmented reality accuracy performance. , 2001 .

[52]  Simon R. Arridge,et al.  An Atlas-Based Segmentation Propagation Framework Using Locally Affine Registration - Application to Automatic Whole Heart Segmentation , 2008, MICCAI.

[53]  Volkmar Falk,et al.  Transapical aortic valve implantation: step by step. , 2009, The Annals of thoracic surgery.

[54]  Douglas L. Jones,et al.  Mitral valve implantation using off-pump closed beating intracardiac surgery: a feasibility study. , 2007, Interactive cardiovascular and thoracic surgery.

[55]  Daniel Rueckert,et al.  Construction of a Statistical Model for Cardiac Motion Analysis Using Nonrigid Image Registration , 2003, IPMI.

[56]  L. Axel,et al.  MR imaging of motion with spatial modulation of magnetization. , 1989, Radiology.

[57]  R. Kikinis,et al.  Superconducting open-configuration MR imaging system for image-guided therapy. , 1995, Radiology.

[58]  Steen Moeller,et al.  SWIFT detection of SPIO‐labeled stem cells grafted in the myocardium , 2010, Magnetic resonance in medicine.

[59]  D. Dvir,et al.  Percutaneous aortic valve implantation in patients with coronary artery disease: review of therapeutic strategies. , 2009, The Journal of invasive cardiology.

[60]  Stephan G. Nekolla,et al.  PET and MRI in cardiac imaging: from validation studies to integrated applications , 2009, European Journal of Nuclear Medicine and Molecular Imaging.

[61]  Qi Zhang,et al.  Dynamic real-time 4D cardiac MDCT image display using GPU-accelerated volume rendering , 2009, Comput. Medical Imaging Graph..

[62]  Douglas L. Jones,et al.  An augmented reality environment for image-guidance of off-pump mitral valve implantation , 2007, SPIE Medical Imaging.

[63]  Terry M. Peters,et al.  Evaluation of Model-Enhanced Ultrasound-Assisted Interventional Guidance in a Cardiac Phantom , 2010, IEEE Transactions on Biomedical Engineering.

[64]  L. V. von Segesser,et al.  Transapical aortic valve implantation without angiography: proof of concept. , 2010, The Annals of thoracic surgery.

[65]  Frank J Rybicki,et al.  Three dimensional computed tomographic imaging in planning the surgical approach for redo cardiac surgery after coronary revascularization. , 2005, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[66]  C. Kalbaugh,et al.  Effects of increased vascular surgical specialization on general surgery trainees, practicing surgeons, and the provision of vascular surgical care. , 2009, Journal of the American College of Surgeons.

[67]  D. Cantor Pioneers and early years. A history of British radiology , 1988, Medicina e historia.

[68]  R Fahrig,et al.  Three-dimensional computed tomographic reconstruction using a C-arm mounted XRII: image-based correction of gantry motion nonidealities. , 2000, Medical physics.

[69]  J P Rolland,et al.  Towards a novel augmented-reality tool to visualize dynamic 3-D anatomy. , 1997, Studies in health technology and informatics.

[70]  Terry M. Peters,et al.  A High Resolution Dynamic Heart Model Based on Averaged MRI Data , 2003, MICCAI.

[71]  O. Burgert,et al.  Towards a new image guidance system for assisting transapical minimally invasive aortic valve implantation , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[72]  Ralph J Damiano Robotics in cardiac surgery: the Emperor's new clothes. , 2007, The Journal of thoracic and cardiovascular surgery.

[73]  Eliot Winer,et al.  A framework for interactive visualization of digital medical images. , 2008, Journal of laparoendoscopic & advanced surgical techniques. Part A.

[74]  K. Rhode,et al.  Echocardiography to magnetic resonance image registration for use in image-guided cardiac catheterization procedures. , 2009, Physics in medicine and biology.

[75]  M. Castellà,et al.  Thoracoscopic pulmonary vein isolation in patients with atrial fibrillation and failed percutaneous ablation. , 2010, The Journal of thoracic and cardiovascular surgery.

[76]  M S Eljamel,et al.  Accuracy, efficacy, and clinical applications of the Radionics Operating Arm System. , 1997, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[77]  W. Eric L. Grimson,et al.  Experimentation with a transcranial magnetic stimulation system for functional brain mapping , 1998, Medical Image Anal..

[78]  Terry M. Peters,et al.  Validation of dynamic heart models obtained using non-linear registration for virtual reality training, planning, and guidance of minimally invasive cardiac surgeries , 2004, Medical Image Anal..

[79]  Hideyuki Sakurai,et al.  CT-fluoroscopy guided interstitial brachytherapy with image-based treatment planning for unresectable locally recurrent rectal carcinoma. , 2004, Brachytherapy.

[80]  Maurice Anidjar,et al.  Hybrid augmented reality simulator: preliminary construct validation of laparoscopic smoothness in a urology residency program. , 2008, The Journal of urology.

[81]  Dimitris N. Metaxas,et al.  Open science - combining open data and open source software: Medical image analysis with the Insight Toolkit , 2005, Medical Image Anal..

[82]  Douglas L. Jones,et al.  Inside the beating heart: an in vivo feasibility study on fusing pre- and intra-operative imaging for minimally invasive therapy , 2009, International Journal of Computer Assisted Radiology and Surgery.

[83]  Peter Anderson,et al.  Method for estimating dynamic EM tracking accuracy of surgical navigation tools , 2006, SPIE Medical Imaging.

[84]  Frank Sauer,et al.  Registration of high-resolution 3D atrial images with electroanatomical cardiac mapping: evaluation of registration methodology , 2005, SPIE Medical Imaging.

[85]  S. Schmerber,et al.  Accuracy evaluation of a CAS system: laboratory protocol and results with 6D localizers, and clinical experiences in otorhinolaryngology. , 2001, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[86]  Ben Blachnitzky,et al.  Augmented reality , 2012, 2012 IEEE Hot Chips 24 Symposium (HCS).

[87]  Mireille Garreau,et al.  A Hybrid Tissue-Level Model of the Left Ventricle: Application to the Analysis of the Regional Cardiac Function in Heart Failure , 2009, FIMH.

[88]  Michael Figl,et al.  Image guidance for robotic minimally invasive coronary artery bypass , 2010, Comput. Medical Imaging Graph..

[89]  P. J. De Feyter,et al.  Percutaneous coronary intervention for chronic total occlusions: value of preprocedural multislice CT guidance , 2007 .

[90]  Takeo Kanade,et al.  An Image Overlay System for Medical Data Visualization , 1998, MICCAI.

[91]  H Bergmann,et al.  Positioning of dental implants using computer-aided navigation and an optical tracking system: case report and presentation of a new method. , 1999, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[92]  K. Cleary,et al.  Navigation with electromagnetic tracking for interventional radiology procedures: a feasibility study. , 2005, Journal of vascular and interventional radiology : JVIR.

[93]  Robert Rohling,et al.  Automatic registration of 3-D ultrasound images , 1998, Sixth International Conference on Computer Vision (IEEE Cat. No.98CH36271).

[94]  Fumio Kishino,et al.  Investigation of Errors in Perception of Stereoscopically Presented Virtual Object Locations in Real Display Space , 1994 .

[95]  Jeroen J. Bax,et al.  Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients. , 2006, European heart journal.

[96]  Nassir Navab,et al.  Depth Perception - A Major Issue in Medical AR: Evaluation Study by Twenty Surgeons , 2006, MICCAI.

[97]  Discovery of the first human stereotactic instrument. , 1983, Applied neurophysiology.

[98]  Richard A. Robb,et al.  Visualization in Image-Guided Interventions , 2008 .

[99]  Volkmar Falk,et al.  The Cardica C-Port System: clinical and angiographic evaluation of a new device for automated, compliant distal anastomoses in coronary artery bypass grafting surgery--a multicenter prospective clinical trial. , 2005, The Journal of thoracic and cardiovascular surgery.

[100]  Abbas Samani,et al.  Towards a biomechanics-based technique for assessing myocardial contractility: an inverse problem approach , 2008, Computer methods in biomechanics and biomedical engineering.

[101]  Ziv Yaniv,et al.  Needle-Based Interventions With the Image-Guided Surgery Toolkit (IGSTK): From Phantoms to Clinical Trials , 2010, IEEE Transactions on Biomedical Engineering.

[102]  Alejandro F. Frangi,et al.  Automatic construction of multiple-object three-dimensional statistical shape models: application to cardiac modeling , 2002, IEEE Transactions on Medical Imaging.

[103]  Olga Bondarenko,et al.  Standardizing the definition of hyperenhancement in the quantitative assessment of infarct size and myocardial viability using delayed contrast-enhanced CMR. , 2005, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[104]  Masato Otsuka,et al.  Utility of multislice computed tomography as a strategic tool for complex percutaneous coronary intervention , 2008, The International Journal of Cardiovascular Imaging.

[105]  Terry M. Peters,et al.  A Statistical Model for Point-Based Target Registration Error With Anisotropic Fiducial Localizer Error , 2008, IEEE Transactions on Medical Imaging.

[106]  W J Viant The development of an evaluation framework for the quantitative assessment of computer-assisted surgery and augmented reality accuracy performance. , 2001, Studies in health technology and informatics.

[107]  Rajni V. Patel,et al.  Optimizing port placement for robot‐assisted minimally invasive cardiac surgery , 2007, The international journal of medical robotics + computer assisted surgery : MRCAS.

[108]  J. Wong,et al.  Flat-panel cone-beam computed tomography for image-guided radiation therapy. , 2002, International journal of radiation oncology, biology, physics.

[109]  Kawal S. Rhode,et al.  Rapid Image Registration of Three-Dimensional Transesophageal Echocardiography and X-ray Fluoroscopy for the Guidance of Cardiac Interventions , 2010, IPCAI.

[110]  S.A.M. Baert,et al.  Three-dimensional guide-wire reconstruction from biplane image sequences for integrated display in 3-D vasculature , 2003, IEEE Transactions on Medical Imaging.

[111]  Eduardo E. Lovo,et al.  A NOVEL, INEXPENSIVE METHOD OF IMAGE COREGISTRATION FOR APPLICATIONS IN IMAGE‐GUIDED SURGERY USING AUGMENTED REALITY , 2007, Neurosurgery.

[112]  C. Pelizzari,et al.  Accurate Three‐Dimensional Registration of CT, PET, and/or MR Images of the Brain , 1989, Journal of computer assisted tomography.

[113]  Wolfgang Birkfellner,et al.  Computer-enhanced stereoscopic vision in a head-mounted operating binocular. , 2003, Physics in medicine and biology.

[114]  Ken Masamune,et al.  Three-Dimensional Slice Image Overlay System with Accurate Depth Perception for Surgery , 2000, MICCAI.

[115]  Z. Yaniv Rigid Registration , 2007 .

[116]  W Lauriola,et al.  3D angiography in the evaluation of intracranial aneurysms before and after treatment. Initial experience. , 2005, La Radiologia medica.

[117]  W. Daniel,et al.  Port-Access coronary artery bypass grafting with the use of cardiopulmonary bypass and cardioplegic arrest. , 1998, The Annals of thoracic surgery.

[118]  R. Kikinis,et al.  Development and implementation of intraoperative magnetic resonance imaging and its neurosurgical applications. , 1997, Neurosurgery.

[119]  Edmunds Lh,et al.  Why cardiopulmonary bypass makes patients sick: strategies to control the blood-synthetic surface interface. , 1995 .

[120]  R. Gibbons,et al.  Prognostic significance of ischemic electrocardiographic changes during vasodilator stress testing in patients with normal SPECT images , 2003, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[121]  Hervé Delingette,et al.  Personalised Electromechanical Model of the Heart for the Prediction of the Acute Effects of Cardiac Resynchronisation Therapy , 2009, FIMH.

[122]  G H Barnett,et al.  Use of a frameless, armless stereotactic wand for brain tumor localization with two-dimensional and three-dimensional neuroimaging. , 1993, Neurosurgery.

[123]  Max A. Viergever,et al.  Image guidance of endovascular interventions on a clinical MR scanner , 1998, IEEE Transactions on Medical Imaging.

[124]  Robert D. Howe,et al.  GPU Based Real-Time Instrument Tracking with Three Dimensional Ultrasound , 2006, MICCAI.

[125]  Olga Bondarenko,et al.  Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction. , 2003, Journal of the American College of Cardiology.

[126]  Jeroen J. Bax,et al.  Effect of Posterolateral Scar Tissue on Clinical and Echocardiographic Improvement After Cardiac Resynchronization Therapy , 2006, Circulation.

[127]  Maria Drangova,et al.  Fused whole-heart coronary and myocardial scar imaging using 3-T CMR. Implications for planning of cardiac resynchronization therapy and coronary revascularization. , 2010, JACC. Cardiovascular imaging.

[128]  Robert D. Howe,et al.  Ultrasound Servoing of Catheters for Beating Heart Valve Repair , 2010, IPCAI.

[129]  R A Robb,et al.  3-D visualization in biomedical applications. , 1999, Annual review of biomedical engineering.

[130]  Thomas Neumann,et al.  Pulmonary Vein Antrum Isolation and Terminal Part of the P Wave , 2010, Pacing and clinical electrophysiology : PACE.

[131]  D. Long,et al.  Frameless stereotaxic integration of CT imaging data: accuracy and initial applications. , 1993, Radiology.

[132]  L. Auer,et al.  Practical application of intraoperative ultrasound imaging , 2005, Acta Neurochirurgica.

[133]  M. Garreau,et al.  MSCT labelling for pre-operative planning in cardiac resynchronization therapy. , 2005, Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society.

[134]  J. Engvall,et al.  Semi-automatic quantification of myocardial infarction from delayed contrast enhanced magnetic resonance imaging , 2005, Scandinavian cardiovascular journal : SCJ.

[135]  Robin O Cleveland,et al.  Three-dimensional echocardiography-guided beating-heart surgery without cardiopulmonary bypass: a feasibility study. , 2004, Journal of Thoracic and Cardiovascular Surgery.

[136]  O. Simonetti,et al.  The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. , 2000, The New England journal of medicine.

[137]  Helmar Bergmann,et al.  Design and application of an assessment protocol for electromagnetic tracking systems. , 2005, Medical physics.

[138]  Ekkehard Euler,et al.  Hybrid Navigation Interface for Orthopedic and Trauma Surgery , 2006, MICCAI.

[139]  R. Lederman,et al.  MRI‐guided myocardial cell therapy , 2005, International journal of cardiovascular interventions.

[140]  A. Moss,et al.  Imaging Modalities , 1982, IEEE Transactions on Medical Imaging.

[141]  C. Nimsky,et al.  Intraoperative magnetic resonance imaging with the magnetom open scanner: concepts, neurosurgical indications, and procedures: a preliminary report. , 1998, Neurosurgery.

[142]  B. Wilson,et al.  Volume CT with a flat-panel detector on a mobile, isocentric C-arm: pre-clinical investigation in guidance of minimally invasive surgery. , 2005, Medical physics.

[143]  V A Subramanian,et al.  Minimally invasive direct coronary artery bypass grafting: two-year clinical experience. , 1997, The Annals of thoracic surgery.

[144]  Fumio Kishino,et al.  Augmented reality: a class of displays on the reality-virtuality continuum , 1995, Other Conferences.

[145]  C. Kramer,et al.  MRI for the diagnosis of myocardial ischemia and viability , 2003, Current opinion in cardiology.

[146]  Paul J. Besl,et al.  A Method for Registration of 3-D Shapes , 1992, IEEE Trans. Pattern Anal. Mach. Intell..

[147]  Henning Rud Andersen History of Percutaneous Aortic Valve Prosthesis , 2009, Herz.

[148]  Richard A. Robb,et al.  New algorithm for efficient polygon decimation for virtual reality applications in medicine , 1997, Medical Imaging.

[149]  F. Langlotz,et al.  Clinical evaluation of a system for precision enhancement in spine surgery. , 1995, Clinical biomechanics.

[150]  Terry M. Peters,et al.  Predicting Target Vessel Location for Improved Planning of Robot-Assisted CABG Procedures , 2010, MICCAI.

[151]  Volker Rasche,et al.  Intra-operative Volume Imaging of the Left Atrium and Pulmonary Veins with Rotational X-Ray Angiography , 2006, MICCAI.

[152]  Ergin Atalar,et al.  Multiple field of view MR fluoroscopy , 2002, Magnetic resonance in medicine.

[153]  Ming Li,et al.  Real‐time interactive MRI‐guided cardiac surgery: Aortic valve replacement using a direct apical approach , 2006, Magnetic resonance in medicine.

[154]  Thomas P. Caudell Introduction to augmented and virtual reality , 1995, Other Conferences.

[155]  D. Hill,et al.  Augmentation of reality using an operating microscope for otolaryngology and neurosurgical guidance. , 1995, Journal of image guided surgery.

[156]  Wiro J. Niessen Model-Based Image Segmentation for Image-Guided Interventions , 2008 .

[157]  Wolfgang Birkfellner,et al.  A head-mounted operating binocular for augmented reality visualization in medicine - design and initial evaluation , 2002, IEEE Transactions on Medical Imaging.

[158]  Olivier Ecabert,et al.  Automatic Model-Based Segmentation of the Heart in CT Images , 2008, IEEE Transactions on Medical Imaging.

[159]  Antonio Abbate,et al.  The future of new aortic valve replacement approaches. , 2010, Future cardiology.

[160]  D. Stoianovici,et al.  Robotically driven interventions: a method of using CT fluoroscopy without radiation exposure to the physician. , 2002, Radiology.

[161]  P. Milgram,et al.  A Taxonomy of Mixed Reality Visual Displays , 1994 .

[162]  Max A. Viergever,et al.  Adaptive local multi-atlas segmentation: Application to the heart and the caudate nucleus , 2010, Medical Image Anal..

[163]  Aaron Fenster,et al.  A Pulsating Coronary Vessel Phantom for Two- and Three-Dimensional Intravascular Ultrasound Studies , 2001, MICCAI.

[164]  P. D. del Nido,et al.  Robotic-assisted closure of atrial septal defect under real-time three-dimensional echo guide: in vitro study. , 2007, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[165]  Jeremy N Ruskin,et al.  The coronary venous anatomy: a segmental approach to aid cardiac resynchronization therapy. , 2005, Journal of the American College of Cardiology.

[166]  Joy C. Peacock,et al.  Robotic techniques improve quality of life in patients undergoing atrial septal defect repair. , 2004, The Annals of thoracic surgery.

[167]  Terry M. Peters,et al.  Integration of trans-esophageal echocardiography with magnetic tracking technology for cardiac interventions , 2010, Medical Imaging.

[168]  M.P. Fronheiser,et al.  3-D ultrasound guidance of surgical robotics using catheter transducers: Feasibility study , 2008, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[169]  J. Anon,et al.  Computer‐aided endoscopic sinus surgery , 1998, The Laryngoscope.

[170]  S. Dymarkowski,et al.  Delayed contrast–enhanced MRI: use in myocardial viability assessment and other cardiac pathology , 2005, European radiology.

[171]  K. Cleary,et al.  Image-guided interventions : technology and applications , 2008 .

[172]  Douglas L. Jones,et al.  2D Ultrasound Augmented by Virtual Tools for Guidance of Interventional Procedures , 2007, MMVR.

[173]  E. McVeigh Measuring mechanical function in the failing heart. , 2006, Journal of electrocardiology.

[174]  Olivier Ecabert,et al.  Automatic Segmentation of Rotational X-Ray Images for Anatomic Intra-Procedural Surface Generation in Atrial Fibrillation Ablation Procedures , 2010, IEEE Transactions on Medical Imaging.

[175]  Hervé Delingette,et al.  Simulation of cardiac pathologies using an electromechanical biventricular model and XMR interventional imaging , 2005, Medical Image Anal..

[176]  E P Wilkinson,et al.  Comparative tracking error analysis of five different optical tracking systems. , 2000, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[177]  E.M. Friets,et al.  Curvature-based nonfiducial registration for the frameless stereotactic operating microscope , 1995, IEEE Transactions on Biomedical Engineering.

[178]  M. Mack,et al.  Present role of thoracoscopy in the diagnosis and treatment of diseases of the chest. , 1992, The Annals of thoracic surgery.

[179]  H. O. Farouque,et al.  Advances in percutaneous treatment for adult valvular heart disease , 2009, Internal medicine journal.

[180]  T. Mihaljevic,et al.  Transapical aortic valve implantation: an animal feasibility study. , 2006, The Annals of thoracic surgery.

[181]  G. Hounsfield Computerized transverse axial scanning (tomography): Part I. Description of system. 1973. , 1973, The British journal of radiology.

[182]  Daniel Rueckert,et al.  Construction of a 4D Statistical Atlas of the Cardiac Anatomy and Its Use in Classification , 2005, MICCAI.

[183]  Daniel Rueckert,et al.  Atlas-Based Segmentation and Tracking of 3D Cardiac MR Images Using Non-rigid Registration , 2002, MICCAI.

[184]  N. Navab,et al.  Advanced Medical Displays: A Literature Review of Augmented Reality , 2008, Journal of Display Technology.

[185]  Makoto Hashizume,et al.  Intraoperative Magnetic Tracker Calibration Using a Magneto-Optic Hybrid Tracker for 3-D Ultrasound-Based Navigation in Laparoscopic Surgery , 2008, IEEE Transactions on Medical Imaging.

[186]  T. Peters Image-guidance for surgical procedures , 2006, Physics in medicine and biology.

[187]  H Bergmann,et al.  Systematic distortions in magnetic position digitizers. , 1998, Medical physics.

[188]  Terry M. Peters,et al.  Object identification accuracy under ultrasound enhanced virtual reality for minimally invasive cardiac surgery , 2008, SPIE Medical Imaging.

[189]  Raúl San José Estépar,et al.  Natural Orifice Transluminal Endoscopic Surgery (NOTES): An Opportunity for Augmented Reality Guidance , 2007, MMVR.

[190]  Andrew D. Wiles,et al.  Virtual reality-enhanced ultrasound guidance: A novel technique for intracardiac interventions , 2008, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[191]  Derek R. Magee,et al.  An augmented reality simulator for ultrasound guided needle placement training , 2007, Medical & Biological Engineering & Computing.

[192]  Ali Serdar Gözen,et al.  Augmented reality: a new tool to improve surgical accuracy during laparoscopic partial nephrectomy? Preliminary in vitro and in vivo results. , 2009, European urology.

[193]  Nassir Navab,et al.  The Virtual Mirror: A New Interaction Paradigm for Augmented Reality Environments , 2009, IEEE Transactions on Medical Imaging.

[194]  Qi Zhang,et al.  A two-level transfer function based method for heart display with vascular tissue and scar enhancement , 2009, 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro.

[195]  M. Penicka,et al.  Myocardial viability and cardiac dyssynchrony as strong predictors of perioperative mortality in high-risk patients with ischemic cardiomyopathy having coronary artery bypass surgery. , 2009, The Journal of thoracic and cardiovascular surgery.

[196]  Peter P. Liu,et al.  Early detection of myocardial dysfunction and heart failure , 2010, Nature Reviews Cardiology.

[197]  R A Robb,et al.  An integrated system for real-time image guided cardiac catheter ablation. , 2006, Studies in health technology and informatics.

[198]  W. Chitwood,et al.  Robotic mitral valve surgery: a United States multicenter trial. , 2005, The Journal of thoracic and cardiovascular surgery.

[199]  Andrew D. Wiles,et al.  Accuracy assessment and interpretation for optical tracking systems , 2004, Medical Imaging: Image-Guided Procedures.

[200]  K. Cleary,et al.  Image Guided Interventions. , 2020, Biomedizinische Technik. Biomedical engineering.

[201]  R Kikinis,et al.  Magnetic resonance imaging therapy. Intraoperative MR imaging. , 1996, Neurosurgery clinics of North America.

[202]  F. Kishino,et al.  Cooperative work environment using virtual workspace , 1992, CSCW '92.

[203]  Nassir Navab,et al.  Recovery of Surgical Workflow Without Explicit Models , 2006, MICCAI.

[204]  Jing Ren,et al.  Rapid Dynamic Image Registration of the Beating Heart for Diagnosis and Surgical Navigation , 2009, IEEE Transactions on Medical Imaging.

[205]  N. Hata,et al.  An integrated visualization system for surgical planning and guidance using image fusion and an open MR , 2001, Journal of magnetic resonance imaging : JMRI.

[206]  M. Rodriguez-Porcel In Vivo Imaging and Monitoring of Transplanted Stem Cells: Clinical Applications , 2010, Current Cardiology Reports.

[207]  John Whitman,et al.  Autonomous Surgical Robotics Using 3-D Ultrasound Guidance: Feasibility Study , 2007, Ultrasonic imaging.

[208]  Terry M. Peters,et al.  Targeting Accuracy under Model-to-Subject Misalignments in Model-Guided Cardiac Surgery , 2009, MICCAI.

[209]  William J. Schroeder,et al.  Visualizing with VTK: A Tutorial , 2000, IEEE Computer Graphics and Applications.

[210]  T. Peters,et al.  Overview and History of Image-Guided Interventions , 2008 .

[211]  M Billinghurst,et al.  New interface metaphors for complex information space visualization: an ECG monitor object prototype. , 1997, Studies in health technology and informatics.

[212]  Kaicheng Liang,et al.  Three-dimensional ultrasound guidance of autonomous robotic breast biopsy: feasibility study. , 2010, Ultrasound in medicine & biology.

[213]  P. Kelly,et al.  Computer-assisted stereotactic microsurgery for the treatment of intracranial neoplasms. , 1982, Neurosurgery.

[214]  William E. Lorensen,et al.  Marching cubes: A high resolution 3D surface construction algorithm , 1987, SIGGRAPH.

[215]  P Munger,et al.  Comparison of relative accuracy between a mechanical and an optical position tracker for image-guided neurosurgery. , 1995, Journal of image guided surgery.

[216]  Nicholas Ayache,et al.  Characterization of Post-infarct Scars in a Porcine Model - A Combined Experimental and Theoretical Study , 2009, FIMH.

[217]  Adrian Iftene,et al.  Augmented Reality , 2010, 2010 12th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing.

[218]  Wolfgang Birkfellner,et al.  Calibration of tracking systems in a surgical environment , 1998, IEEE Transactions on Medical Imaging.

[219]  Daniel Rueckert,et al.  Segmentation of 4D Cardiac MR Images Using a Probabilistic Atlas and the EM Algorithm , 2003, MICCAI.

[220]  Ivan Poupyrev,et al.  3D User Interfaces: Theory and Practice , 2004 .

[221]  R C Grimm,et al.  Real‐time interactive magnetic resonance imaging , 1990, Magnetic resonance in medicine.

[222]  L. V. von Segesser,et al.  Feasibility of transapical aortic valve implantation guided by intracardiac ultrasound without angiography. , 2010, The Journal of thoracic and cardiovascular surgery.

[223]  Richard A. Robb,et al.  Developing patient-specific anatomic models for validation of cardiac ablation guidance procedures , 2008, SPIE Medical Imaging.

[224]  W. Boyd,et al.  Hybrid robotic coronary artery surgery and angioplasty in multivessel coronary artery disease. , 2002, The Annals of thoracic surgery.

[225]  Bo Li,et al.  GPU Accelerated Non-rigid Registration for the Evaluation of Cardiac Function , 2008, MICCAI.

[226]  Rui Liao,et al.  Image Guidance of Intracardiac Ultrasound with Fusion of Pre-operative Images , 2007, MICCAI.

[227]  H. Bail,et al.  Advancements in Orthopedic Intervention: Retrograde Drilling and Bone Grafting of Osteochondral Lesions of the Knee Using Magnetic Resonance Imaging Guidance , 2010, CardioVascular and Interventional Radiology.

[228]  D. Hill,et al.  Medical image registration , 2001, Physics in medicine and biology.

[229]  M. Mack,et al.  Minimally invasive and robotic surgery. , 2001, JAMA.

[230]  Pedro J del Nido,et al.  Stereoscopic vision display technology in real-time three-dimensional echocardiography-guided intracardiac beating-heart surgery. , 2008, The Journal of thoracic and cardiovascular surgery.

[231]  Frank Sauer,et al.  A Novel Phantom-Less Spatial and Temporal Ultrasound Calibration Method , 2005, MICCAI.

[232]  Kawal S. Rhode,et al.  A system for real-time XMR guided cardiovascular intervention , 2005, IEEE Transactions on Medical Imaging.

[233]  Cengizhan Ozturk,et al.  Real‐time MRI guided atrial septal puncture and balloon septostomy in swine , 2006, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[234]  Cengizhan Ozturk,et al.  Invasive human magnetic resonance imaging: Feasibility during revascularization in a combined XMR suite , 2005 .

[235]  H Reichenspurner,et al.  Preoperative 3D-reconstructions of ultrafast-CT images for the planning of minimally invasive direct coronary artery bypass operation (MIDCAB). , 1998, The heart surgery forum.

[236]  T. Peters,et al.  Intraoperative ultrasound for guidance and tissue shift correction in image-guided neurosurgery. , 2000, Medical physics.

[237]  A. Gillinov,et al.  Video-assisted bilateral pulmonary vein isolation and left atrial appendage exclusion for atrial fibrillation. , 2005, The Journal of thoracic and cardiovascular surgery.

[238]  Ramin Shahidi,et al.  Validation of medical image processing in image-guided therapy , 2002, IEEE Transactions on Medical Imaging.

[239]  Jonathan M Sorger,et al.  Real-time volume rendered MRI for interventional guidance. , 2002, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[240]  Ziv Yaniv,et al.  The Image-Guided Surgery Toolkit IGSTK: An Open Source C++ Software Toolkit , 2007, Journal of Digital Imaging.

[241]  Lewis D. Griffin,et al.  Zen and the art of medical image registration: correspondence, homology, and quality , 2003, NeuroImage.

[242]  Joel Waldfogel,et al.  Introduction , 2010, Inf. Econ. Policy.

[243]  Jeroen J. Bax,et al.  Non-invasive visualization of the cardiac venous system in coronary artery disease patients using 64-slice computed tomography. , 2006, Journal of the American College of Cardiology.