Use of vimentin immunocytochemical staining for evaluation of atypical cells in voided urine samples

Cytomorphology of exfoliated atypical reactive/repair renal tubular cells (RRTC) can resemble atypical urothelial cells thus suggesting a differential diagnostic question of urothelial neoplasia in urinary cytology. Vimentin expression has been shown in RRTC and used for differentiation from atypical urothelial cells.

[1]  C. VandenBussche,et al.  Benign‐appearing urothelial tissue fragments in noninstrumented voided urine specimens are associated with low rates of urothelial neoplasia , 2015, Cancer cytopathology.

[2]  C. VandenBussche,et al.  Atypical urothelial tissue fragments in noninstrumented voided urine specimens are associated with low but significantly higher rates of urothelial neoplasia than benign‐appearing urothelial tissue fragments , 2015, Cancer cytopathology.

[3]  H. Miyake,et al.  Expression profile of epithelial-mesenchymal transition markers in non-muscle-invasive urothelial carcinoma of the bladder: correlation with intravesical recurrence following transurethral resection. , 2015, Urologic oncology.

[4]  Chunxi Wang,et al.  Expression of HMGA2 in bladder cancer and its association with epithelial‐to‐mesenchymal transition , 2014, Cell proliferation.

[5]  Kwan-Kyu Park,et al.  The differential expression of TGF-β1, ILK and wnt signaling inducing epithelial to mesenchymal transition in human renal fibrogenesis: an immunohistochemical study. , 2013, International journal of clinical and experimental pathology.

[6]  C. VandenBussche,et al.  The Johns Hopkins Hospital template for urologic cytology samples , 2013, Cancer cytopathology.

[7]  Yair Lotan,et al.  ICUD-EAU International Consultation on Bladder Cancer 2012: Screening, diagnosis, and molecular markers. , 2013, European urology.

[8]  R. Haba,et al.  Expression of vimentin and high‐molecular‐weight cytokeratin (clone 34ßE12) in differentiating reactive renal tubular cells from low‐grade urothelial carcinoma cells in voided urine , 2011, Cytopathology : official journal of the British Society for Clinical Cytology.

[9]  L. Bubendorf Multiprobe Fluorescence in situ Hybridization (UroVysion) for the Detection of Urothelial Carcinoma – FISHing for the Right Catch , 2011, Acta Cytologica.

[10]  R. Haba,et al.  Can cytological features differentiate reactive renal tubular cells from low‐grade urothelial carcinoma cells? , 2010, Cytopathology : official journal of the British Society for Clinical Cytology.

[11]  Leopold G. Koss,et al.  Kosss diagnostic cytology and its histopathologic bases , 2017 .

[12]  G. Nguyen,et al.  Repair renal tubular cells: A potential false‐positive diagnosis in urine cytology , 2004, Diagnostic cytopathology.

[13]  S. Wilczynski,et al.  The accuracy of urinary cytology in daily practice , 1999, Cancer.

[14]  D. Gupta,et al.  Calculus artifact. A challenge in urinary cytology. , 1999, Acta cytologica.

[15]  J. Ward,et al.  Vimentin metaplasia in renal cortical tubules of preneoplastic, neoplastic, aging, and regenerative lesions of rats and humans. , 1992, The American journal of pathology.

[16]  R. Moll,et al.  Expression of intermediate filament proteins in fetal and adult human kidney: modulations of intermediate filament patterns during development and in damaged tissue. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[17]  U. Helmchen,et al.  Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. , 1987, The American journal of pathology.