The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation
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J. Kutok | D. Fruman | S. Mallya | J. P. DiNitto | Erin E Brophy | Erin E. Brophy | D. Winkler | Karen McGovern | Leandra V. Jackson | Honyin Chiu | A. Mai | Phuongthao Nguyen | Sharmila Mallya | L. Jackson
[1] P. Hawkins,et al. PI3K signalling in inflammation. , 2015, Biochimica et biophysica acta.
[2] Xiaolin Hao,et al. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. , 2015, Journal of medicinal chemistry.
[3] D. Fruman,et al. mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition , 2014, Proceedings of the National Academy of Sciences.
[4] C. Rommel,et al. PI3K and cancer: lessons, challenges and opportunities , 2014, Nature Reviews Drug Discovery.
[5] Bonnie Tillotson,et al. PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. , 2013, Chemistry & biology.
[6] Nada Jabado,et al. Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage , 2013, Science.
[7] J. B. Oliveira,et al. Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency , 2013, Nature Immunology.
[8] T. Rao,et al. PI3Kγ kinase activity is required for optimal T-cell activation and differentiation , 2013, European journal of immunology.
[9] Mengrou Lu,et al. Selective Inhibition of Phosphoinositide 3-Kinase p110α Preserves Lymphocyte Function* , 2012, The Journal of Biological Chemistry.
[10] D. Whittington,et al. Discovery and in vivo evaluation of dual PI3Kβ/δ inhibitors. , 2012, Journal of medicinal chemistry.
[11] M. Gold,et al. Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies , 2012, Front. Immun..
[12] D. Fruman,et al. Akt and mTOR in B Cell Activation and Differentiation , 2012, Front. Immun..
[13] C. Rommel,et al. PI3Kδ inhibitors in cancer: rationale and serendipity merge in the clinic. , 2011, Cancer discovery.
[14] E. Hirsch,et al. Phosphoinositide 3‐kinase p110γ in immunity , 2011, IUBMB life.
[15] J. Alferink,et al. The catalytic PI3K isoforms p110γ and p110δ contribute to B cell development and maintenance, transformation, and proliferation , 2010, Journal of leukocyte biology.
[16] Jason S. Mitchell,et al. The p110γ isoform of phosphatidylinositol 3‐kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites , 2008, Journal of leukocyte biology.
[17] S. Jameson,et al. Selective Regulation of CD8 Effector T Cell Migration by the p110γ Isoform of Phosphatidylinositol 3-Kinase1 , 2008, The Journal of Immunology.
[18] K. Calame,et al. Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. , 2006, Immunity.
[19] C. Rommel,et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. , 2006, Journal of medicinal chemistry.
[20] K. Okkenhaug,et al. Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. , 2006, Blood.
[21] K. Okkenhaug,et al. Cutting Edge: Differential Roles for Phosphoinositide 3-Kinases, p110γ and p110δ, in Lymphocyte Chemotaxis and Homing1 , 2004, The Journal of Immunology.
[22] K. Okkenhaug,et al. Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice , 2002, Science.
[23] W L Stanford,et al. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. , 2000, Science.
[24] F. Alt,et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. , 1999, Science.
[25] M. Gold,et al. Phosphoinositide 3-Kinase p110 Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses , 2009 .
[26] K. Okkenhaug,et al. Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. , 2004, Journal of immunology.