Quantitation of lidocaine and its deethylated metabolites in plasma and urine by gas chromatography-mass fragmentography.

[1]  W. Trager,et al.  Quantification of lidocaine and several metabolites utilizing chemical-ionization mass spectrometry and stable isotope labeling. , 1977, Journal of pharmaceutical sciences.

[2]  P. Meffin,et al.  Influence of congestive heart failure on blood levels of lidocaine and its active monodeethylated metabolite , 1975, Clinical pharmacology and therapeutics.

[3]  J. Bigger Pharmacologic and clinical control of antiarrhythmic drugs. , 1975, The American journal of medicine.

[4]  A. Atkinson,et al.  Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide , 1975, Clinical pharmacology and therapeutics.

[5]  D. Harrison,et al.  The Clinical Pharmacology of Lidocaine as an Antiarrhythymic Drug , 1974, Circulation.

[6]  L. Prescott,et al.  Gas‐liquid chromatographic estimation of lignocaine, ethylglycylxylidide, glycylxylidide and 4‐hydroxyxylidine in plasma and urine , 1974, The Journal of pharmacy and pharmacology.

[7]  J. Strong,et al.  The convulsant potency of lidocaine and its N-dealkylated metabolites. , 1973, The Journal of pharmacology and experimental therapeutics.

[8]  W. Steinbrunn,et al.  Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans. , 1973, Annals of internal medicine.

[9]  A. Atkinson,et al.  Identification of glycinexylidide in patients treated with intravenous lidocaine , 1973, Clinical pharmacology and therapeutics.

[10]  A. Atkinson,et al.  Simultaneous measurement of plasma concentratons of lidocaine and its deethylated metabolite by mass fragmentography , 1972 .

[11]  R. Boyes,et al.  The tissue distribution, metabolism and excretion of lidocaine in rats, guinea pigs, dogs and man. , 1972, The Journal of pharmacology and experimental therapeutics.

[12]  E. Smith,et al.  The acute antiarrhythmic and toxic effects in mice and dogs of 2-ethylamino-2',6-'acetoxylidine (L-86), a metabolite of lidocaine. , 1971, The Journal of pharmacology and experimental therapeutics.

[13]  K. Melmon,et al.  DISPOSITION KINETICS OF LIDOCAINE IN NORMAL SUBJECTS * , 1971, Annals of the New York Academy of Sciences.

[14]  D. Scott,et al.  Pharmacokinetics of lidocaine in man , 1971, Clinical pharmacology and therapeutics.

[15]  J. Usubiaga,et al.  Mechanism of Convulsions Elicited by Local Anesthetic Agents: I. Local Anesthetic Depression of Electrically‐Induced Seizures in Man , 1970, Anesthesia and analgesia.