Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

[1]  Maryam Rashidi,et al.  RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL , 2015, Nature Communications.

[2]  A. Burlingame,et al.  A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity. , 2015, Immunity.

[3]  Kenta Moriwaki,et al.  RIP3 induces apoptosis independent of pronecrotic kinase activity. , 2014, Molecular cell.

[4]  Jiahuai Han,et al.  RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway , 2014, Nature Immunology.

[5]  S. Akira,et al.  Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux , 2014, The Journal of Immunology.

[6]  J. Rizo,et al.  A plug release mechanism for membrane permeation by MLKL. , 2014, Structure.

[7]  J. Blander,et al.  A long-awaited merger of the pathways mediating host defence and programmed cell death , 2014, Nature Reviews Immunology.

[8]  D. Green,et al.  RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis , 2014, Cell Death and Differentiation.

[9]  D. Vaux,et al.  RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis , 2014, Cell.

[10]  D. Green,et al.  RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3 , 2014, Cell.

[11]  J. Bertin,et al.  RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition , 2014, Proceedings of the National Academy of Sciences.

[12]  L. Komuves,et al.  Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis , 2014, Science.

[13]  Katherine A. Fitzgerald,et al.  Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes , 2014, Cell.

[14]  D. Green,et al.  FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes , 2014, The Journal of Immunology.

[15]  Philip R. Cohen,et al.  IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation , 2013, Proceedings of the National Academy of Sciences.

[16]  E. Alnemri,et al.  Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome , 2013, The Journal of Immunology.

[17]  Toru Okamoto,et al.  The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. , 2013, Immunity.

[18]  J. Bertin,et al.  Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL* , 2013, The Journal of Biological Chemistry.

[19]  G. Núñez,et al.  K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. , 2013, Immunity.

[20]  E. Latz,et al.  Activation and regulation of the inflammasomes , 2013, Nature Reviews Immunology.

[21]  M. Onori,et al.  Coinfection in acute gastroenteritis predicts a more severe clinical course in children , 2013, European Journal of Clinical Microbiology & Infectious Diseases.

[22]  Andrew Kovalenko,et al.  Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. , 2013, Immunity.

[23]  E. Alnemri,et al.  Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation* , 2012, The Journal of Biological Chemistry.

[24]  W. Cevallos,et al.  Synergistic effects between rotavirus and coinfecting pathogens on diarrheal disease: evidence from a community-based study in northwestern Ecuador. , 2012, American journal of epidemiology.

[25]  D. Green,et al.  Survival function of the FADD-CASPASE-8-cFLIP(L) complex. , 2012, Cell reports.

[26]  Holly Anderton,et al.  Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. , 2012, Immunity.

[27]  Xiaodong Wang,et al.  Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase , 2012, Cell.

[28]  William J. Kaiser,et al.  Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways , 2011, Nature Reviews Immunology.

[29]  Yuqiong Liang,et al.  Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3–mediated pathway , 2011, Proceedings of the National Academy of Sciences.

[30]  R. Hakem,et al.  RIP3 mediates the embryonic lethality of caspase-8-deficient mice , 2011, Nature.

[31]  Guy S. Salvesen,et al.  Catalytic activity of the caspase-8-FLIPL complex inhibits RIPK3-dependent necrosis , 2011, Nature.

[32]  A. Aderem,et al.  The NLRP3 Inflammasome Detects Encephalomyocarditis Virus and Vesicular Stomatitis Virus Infection , 2011, Journal of Virology.

[33]  A. Aderem,et al.  Activation of the NLRP3 inflammasome by intracellular poly I:C , 2010, FEBS letters.

[34]  E. Alnemri,et al.  Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes , 2010, Journal of Clinical Immunology.

[35]  S. Akira,et al.  The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors , 2010, Nature Immunology.

[36]  E. Alnemri,et al.  Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1 , 2009, The Journal of Immunology.

[37]  Satoshi O. Suzuki,et al.  Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice , 2009, Nature Cell Biology.

[38]  F. Chan,et al.  Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation , 2009, Cell.

[39]  E. Alnemri,et al.  AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA , 2009, Nature.

[40]  L. O’Neill,et al.  The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress , 2008, Immunological reviews.

[41]  Lois J. Maltais,et al.  The NLR gene family: a standard nomenclature. , 2008, Immunity.

[42]  E. Alnemri,et al.  Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. , 2007, Molecular cell.

[43]  Yide Mei,et al.  Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. , 2007, Cellular signalling.

[44]  E. Alnemri,et al.  The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation , 2007, Cell Death and Differentiation.

[45]  A. Bowie,et al.  The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling , 2007, Nature Reviews Immunology.

[46]  F. Martinon,et al.  Gout-associated uric acid crystals activate the NALP3 inflammasome , 2006, Nature.

[47]  V. Dixit,et al.  Cryopyrin activates the inflammasome in response to toxins and ATP , 2006, Nature.

[48]  S. Akira,et al.  Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 , 2006, Nature.

[49]  V. Dixit,et al.  Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4 , 2004, Molecular and Cellular Biology.

[50]  S. Akira,et al.  Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway , 2003, Science.

[51]  S. Akira,et al.  Unresponsiveness of MyD88-deficient mice to endotoxin. , 1999, Immunity.

[52]  J. Beckmann,et al.  Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. , 1998, Immunity.

[53]  D. Goeddel,et al.  FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. , 1998, Science.

[54]  N. Kabra,et al.  Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1 , 1998, Nature.

[55]  M. Ammendolia,et al.  Superinfection by Listeria monocytogenes of cultured human enterocyte-like cells infected with poliovirus or rotavirus , 1996, Medical Microbiology and Immunology.

[56]  A. Henderson On standard nomenclature. , 1982, Cytogenetics and cell genetics.

[57]  E. Alnemri,et al.  Assembly, purification, and assay of the activity of the ASC pyroptosome. , 2008, Methods in enzymology.