Lipidized fibrous histiocytoma on the left condyle of the tibia

endopeptidase (NEP) was expressed in the germinative cells of the sebaceous glands in the skin from acne patients. When organ-cultured normal skin specimens were exposed to SP, significant increases in the sizes of the sebaceous glands were observed. These findings suggest that SP may stimulate lipogenesis of the sebaceous glands, which may be followed by proliferation of Propionibacterium acnes; therefore, cutaneous neurogenic factors may contribute to the onset or exacerbation of acne inflammation. Herpes zoster might cause destruction of nerve fibers in the mid and lower dermis, and result in the release of neuropeptides and provocation of comedones development.

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