REINVENT: ERS International survey on REstrictive thoracic diseases IN long term home noninvasive VENTilation

Background and aim Little is known about the current use of long-term home noninvasive ventilation (LTHNIV) in restrictive thoracic diseases, including chest wall disorders and neuromuscular disorders (NMD). This study aimed to capture the pattern of LTHNIV in patients with restrictive thoracic diseases via a web-based international survey. Methods The survey involved European Respiratory Society (ERS) Assembly 2.02 (NIV-dedicated group), from October to December 2019. Results 166 (22.2%) out of 748 members from 41 countries responded; 80% were physicians, of whom 43% worked in a respiratory intermediate intensive care unit. The ratio of NMD to chest wall disorders was 5:1, with amyotrophic lateral sclerosis the most frequent indication within NMD (78%). The main reason to initiate LTHNIV was diurnal hypercapnia (71%). Quality of life/sleep was the most important goal to achieve. In 25% of cases, clinicians based their choice of the ventilator on patients’ feedback. Among NIV modes, spontaneous-timed pressure support ventilation (ST-PSV) was the most frequently prescribed for day- and night-time. Mouthpieces were the preferred daytime NIV interface, whereas oro-nasal masks the first choice overnight. Heated humidification was frequently added to LTHNIV (72%). Single-limb circuits with intentional leaks (79%) were the most frequently prescribed. Follow-up was most often provided in an outpatient setting. Conclusions This ERS survey illustrates physicians’ practices of LTHNIV in patients with restrictive thoracic diseases. NMD and, specifically, amyotrophic lateral sclerosis were the main indications for LTHNIV. NIV was started mostly because of diurnal hypoventilation with a primary goal of patient-centred benefits. Bi-level ST-PSV and oro-nasal masks were more likely to be chosen for providing NIV. LTHNIV efficacy was assessed mainly in an outpatient setting. For the first time since EUROVENT, the REINVENT survey of @EuroRespSoc members expert in noninvasive (NIV) ventilatory support illustrates physicians’ practices of long-term home NIV in restrictive thoracic disorder patients https://bit.ly/2MbC3YI

[1]  W. Windisch,et al.  Outpatient Noninvasive Ventilation: Can the Dutch Setting Serve as a Blueprint for Other Countries? , 2020, Chest.

[2]  N. Cobben,et al.  "A randomized trial of initiation of chronic non-invasive mechanical ventilation at home vs in-hospital in patients with Neuromuscular Disease and thoracic cage disorder": The Dutch Homerun Trial. , 2020, Chest.

[3]  G. Logroscino,et al.  The importance of maintaining the same order of performance of lung function and SNIP tests in patients with amyotrophic lateral sclerosis , 2020, Amyotrophic lateral sclerosis & frontotemporal degeneration.

[4]  J. Pépin,et al.  Long term noninvasive ventilation in the Geneva Lake area: indications, prevalence and modalities. , 2020, Chest.

[5]  J. Bach,et al.  Daytime noninvasive ventilatory support for patients with ventilatory pump failure: a narrative review , 2019, Multidisciplinary Respiratory Medicine.

[6]  J. Vonk,et al.  Home initiation of chronic non-invasive ventilation in COPD patients with chronic hypercapnic respiratory failure: a randomised controlled trial , 2019, Thorax.

[7]  J. Pépin,et al.  European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD , 2019, European Respiratory Journal.

[8]  C. Gregoretti,et al.  Long-Term Ventilation in Neuromuscular Patients: Review of Concerns, Beliefs, and Ethical Dilemmas , 2019, Respiration.

[9]  E. De Mattia,et al.  Passive Versus Active Circuit During Invasive Mechanical Ventilation in Subjects With Amyotrophic Lateral Sclerosis , 2018, Respiratory Care.

[10]  D. Annane,et al.  Mechanical ventilation for amyotrophic lateral sclerosis/motor neuron disease , 2010, The Cochrane database of systematic reviews.

[11]  J. Bach.  Noninvasive Respiratory Management of Patients With Neuromuscular Disease , 2017, Annals of rehabilitation medicine.

[12]  C. Gregoretti,et al.  Long-term volume-targeted pressure-controlled ventilation: sense or nonsense? , 2017, European Respiratory Journal.

[13]  A. Simonds,et al.  AJRCCM: 100-Year Anniversary. Homeward Bound: A Centenary of Home Mechanical Ventilation. , 2017, American journal of respiratory and critical care medicine.

[14]  M. Vitacca,et al.  Early initiation of night-time NIV in an outpatient setting: a randomized non-inferiority study in ALS patients. , 2017, European journal of physical and rehabilitation medicine.

[15]  J. Winck,et al.  Mouthpiece ventilation and complementary techniques in patients with neuromuscular disease: A brief clinical review and update , 2017, Chronic respiratory disease.

[16]  D. McKim,et al.  Daytime Mouthpiece for Continuous Noninvasive Ventilation in Individuals With Amyotrophic Lateral Sclerosis , 2016, Respiratory Care.

[17]  H. Kerstjens,et al.  Is chronic ventilatory support really effective in patients with amyotrophic lateral sclerosis? , 2016, Journal of Neurology.

[18]  D. Cook,et al.  Incentive and Reminder Strategies to Improve Response Rate for Internet-Based Physician Surveys: A Randomized Experiment , 2016, Journal of medical Internet research.

[19]  C. Gregoretti,et al.  Ventilator Settings to Avoid Nuisance Alarms During Mouthpiece Ventilation , 2016, Respiratory Care.

[20]  A. Simonds,et al.  Domiciliary Non-invasive Ventilation in COPD: An International Survey of Indications and Practices , 2016, COPD.

[21]  M. Decramer,et al.  Noninvasive ventilation improves sleep in amyotrophic lateral sclerosis: a prospective polysomnographic study. , 2015, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[22]  C. Gregoretti,et al.  Mouthpiece Ventilation: Just a Home-Care Support? , 2014, Respiratory Care.

[23]  Stefano Nava,et al.  Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. , 2014, The Lancet. Respiratory medicine.

[24]  H. Kerstjens,et al.  Initiation of home mechanical ventilation at home: a randomised controlled trial of efficacy, feasibility and costs. , 2014, Respiratory medicine.

[25]  J. Bach,et al.  Open circuit mouthpiece ventilation: Concise clinical review. , 2014, Revista portuguesa de pneumologia.

[26]  M. Howard,et al.  Improved survival with an ambulatory model of non-invasive ventilation implementation in motor neuron disease , 2014, Amyotrophic lateral sclerosis & frontotemporal degeneration.

[27]  Ilene M Rosen,et al.  The changing landscape of adult home noninvasive ventilation technology, use, and reimbursement in the United States. , 2014, Chest.

[28]  J. Storre,et al.  Target volume settings for home mechanical ventilation: great progress or just a gadget? , 2012, Thorax.

[29]  Adrian J. Williams,et al.  Volume targeted versus pressure support non-invasive ventilation in patients with super obesity and chronic respiratory failure: a randomised controlled trial , 2012, Thorax.

[30]  P. Andersen,et al.  EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force , 2012, European journal of neurology.

[31]  S. Nava,et al.  Survey of non-invasive ventilation practices: a snapshot of Italian practice. , 2011, Minerva anestesiologica.

[32]  Raffaele Scala,et al.  Clinical review: Humidifiers during non-invasive ventilation - key topics and practical implications , 2011, Critical Care.

[33]  S. Nava,et al.  A European survey of noninvasive ventilation practices , 2010, European Respiratory Journal.

[34]  E. Sforza,et al.  Impact of volume targeting on efficacy of bi-level non-invasive ventilation and sleep in obesity-hypoventilation. , 2009, Respiratory medicine.

[35]  S. Sorichter,et al.  Average volume-assured pressure support in obesity hypoventilation: A randomized crossover trial. , 2006, Chest.

[36]  D. Hess.  Noninvasive ventilation in neuromuscular disease: equipment and application. , 2006, Respiratory care.

[37]  P. Shaw,et al.  Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial , 2006, The Lancet Neurology.

[38]  A K Simonds,et al.  Patterns of home mechanical ventilation use in Europe: results from the Eurovent survey , 2005, European Respiratory Journal.

[39]  B. Dautzenberg,et al.  Predictors of survival in patients receiving domiciliary oxygen therapy or mechanical ventilation. A 10-year analysis of ANTADIR Observatory. , 1996, Chest.

[40]  J. M. Lavigne.  Respiratory care of patients with neuromuscular disease. , 1979, The Nursing clinics of North America.

[41]  D. Annane,et al.  Mechanical ventilation for amyotrophic lateral sclerosis/motor neuron disease. , 2009, The Cochrane database of systematic reviews.

[42]  J. Chevrolet,et al.  Changing patterns in long-term noninvasive ventilation: a 7-year prospective study in the Geneva Lake area. , 2003, Chest.

[43]  J. Polu,et al.  Nasal intermittent positive pressure ventilation. Long-term follow-up in patients with severe chronic respiratory insufficiency. , 1994, Chest.