Quantification of mitral valve anatomy by three-dimensional transesophageal echocardiography in mitral valve prolapse predicts surgical anatomy and the complexity of mitral valve repair.

BACKGROUND Three-dimensional (3D) transesophageal echocardiography (TEE) is more accurate than two-dimensional (2D) TEE in the qualitative assessment of mitral valve (MV) prolapse (MVP). However, the accuracy of 3D TEE in quantifying MV anatomy is less well studied, and its clinical relevance for MV repair is unknown. METHODS The number of prolapsed segments, leaflet heights, and annular dimensions were assessed using 2D and 3D TEE and compared with surgical measurements in 50 patients (mean age, 61 ± 11 years) who underwent MV repair for mainly advanced MVP. RESULTS Three-dimensional TEE was more accurate (92%-100%) than 2D TEE (80%-96%) in identifying prolapsed segments. Three-dimensional TEE and intraoperative measurements of leaflet height did not differ significantly, while 2D TEE significantly overestimated the height of the posterior segment P1 and the anterior segment A2. Three-dimensional TEE quantitative MV measurements were related to surgical technique: patients with more complex MVP (one vs two to four vs five or more prolapsed segments) showed progressive enlargement of annular anteroposterior (31 ± 5 vs 34 ± 4 vs 37 ± 6 mm, respectively, P = .02) and commissural diameters (40 ± 6 vs 44 ± 5 vs 50 ± 10 mm, respectively, P = .04) and needed increasingly complex MV repair with larger annuloplasty bands (60 ± 13 vs 67 ± 9 vs 72 ± 10 mm, P = .02) and more neochordae (7 ± 3 vs 12 ± 5 vs 26 ± 6, P < .01). CONCLUSIONS Measurements of MV anatomy on 3D TEE are accurate compared with surgical measurements. Quantitative MV characteristics, as assessed by 3D TEE, determined the complexity of MV repair.

[1]  T. Mihaljevic,et al.  Reoperation after mitral valve repair for degenerative disease. , 2007, The Annals of thoracic surgery.

[2]  R. Suri Large Annuloplasty Rings Facilitate Mitral Valve Repair in Barlow's Disease , 2008 .

[3]  Pamela S Douglas,et al.  ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echoca , 2003, Circulation.

[4]  V. Jeevanandam,et al.  Real-time three-dimensional transesophageal echocardiography in valve disease: comparison with surgical findings and evaluation of prosthetic valves. , 2008, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[5]  Douglas W Mahoney,et al.  Mitral Annular Dynamics in Myxomatous Valve Disease: New Insights With Real-Time 3-Dimensional Echocardiography , 2010, Circulation.

[6]  Gloria Tamborini,et al.  Pre-operative transthoracic real-time three-dimensional echocardiography in patients undergoing mitral valve repair: accuracy in cases with simple vs. complex prolapse lesions. , 2010, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[7]  William A Zoghbi,et al.  Comparative accuracy of two- and three-dimensional transthoracic and transesophageal echocardiography in identifying mitral valve pathology in patients undergoing mitral valve repair: initial observations. , 2011, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[8]  D. Adams,et al.  Seeking a higher standard for degenerative mitral valve repair: begin with etiology. , 2008, The Journal of thoracic and cardiovascular surgery.

[9]  S. Siu,et al.  Intraoperative transesophageal echocardiography accurately predicts mitral valve anatomy and suitability for repair. , 2002, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[10]  S. Armstrong,et al.  A comparison of outcomes of mitral valve repair for degenerative disease with posterior, anterior, and bileaflet prolapse. , 2005, The Journal of thoracic and cardiovascular surgery.

[11]  M. Schemper,et al.  Outcome of Watchful Waiting in Asymptomatic Severe Mitral Regurgitation , 2006, Circulation.

[12]  Imran Syed,et al.  Real-time three-dimensional transesophageal echocardiography in the intraoperative assessment of mitral valve disease. , 2009, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[13]  David H Adams,et al.  Etiologic classification of degenerative mitral valve disease: Barlow's disease and fibroelastic deficiency. , 2007, Seminars in thoracic and cardiovascular surgery.

[14]  V. Jeevanandam,et al.  Quantitative analysis of mitral valve apparatus in mitral valve prolapse before and after annuloplasty: a three-dimensional intraoperative transesophageal study. , 2011, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[15]  O. Alfieri,et al.  Real-time three-dimensional transesophageal echocardiography for assessment of mitral valve functional anatomy in patients with prolapse-related regurgitation. , 2011, The American journal of cardiology.

[16]  M. Enriquez-Sarano,et al.  Valve repair improves the outcome of surgery for mitral regurgitation. A multivariate analysis. , 1995, Circulation.

[17]  J. Zamorano,et al.  Real-Time Three-Dimensional Transesophageal Echocardiography , 2010 .

[18]  A. Carpentier,et al.  Left ventricular outflow obstruction after mitral valve repair (Carpentier's technique). Proposed mechanisms of disease. , 1988, Circulation.

[19]  S Chandra,et al.  Characterization of degenerative mitral valve disease using morphologic analysis of real-time 3D echocardiographic images , 2010, 2010 Computing in Cardiology.

[20]  Volkmar Falk,et al.  Degenerative mitral valve regurgitation: best practice revolution , 2010, European heart journal.

[21]  Victor Mor-Avi,et al.  Characterization of Degenerative Mitral Valve Disease Using Morphologic Analysis of Real-Time Three-Dimensional Echocardiographic Images: Objective Insight Into Complexity and Planning of Mitral Valve Repair , 2011, Circulation. Cardiovascular imaging.

[22]  A. Berrebi,et al.  The "physio-ring": an advanced concept in mitral valve annuloplasty. , 1995, The Annals of thoracic surgery.

[23]  T. David Outcomes of mitral valve repair for mitral regurgitation due to degenerative disease. , 2007, Seminars in thoracic and cardiovascular surgery.

[24]  R A Levine,et al.  Prevalence and clinical outcome of mitral-valve prolapse. , 1999, The New England journal of medicine.

[25]  L. Weinert,et al.  Valvular heart disease. The value of 3-dimensional echocardiography. , 2011, Journal of the American College of Cardiology.

[26]  Rajarshi Dutta,et al.  Comparison of Real Time Two‐Dimensional with Live/Real Time Three‐Dimensional Transesophageal Echocardiography in the Evaluation of Mitral Valve Prolapse and Chordae Rupture , 2008, Echocardiography.

[27]  I. Izrailtyan,et al.  Identifying patients with degenerative mitral regurgitation for mitral valve repair and replacement: a transesophageal echocardiographic study. , 2004, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[28]  D. Adams,et al.  State of the art: degenerative mitral valve disease. , 2009, Heart, lung & circulation.

[29]  Pamela S Douglas,et al.  Acc/aha/ase 2003 Guideline Update for the Clinical Application of Echocardiography: Summary Article a Report of the American College of Cardiology/american Heart Association Task Force on Practice Guidelines (acc/aha/ase Committee to Update the 1997 Guidelines for the Clinical Application of Echocar , 2003 .

[30]  Lynn Weinert,et al.  Mitral annulus dynamics early after valve repair: preliminary observations of the effect of resectional versus non-resectional approaches. , 2011, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[31]  Hartzell V Schaff,et al.  Is the anterior intertrigonal distance increased in patients with mitral regurgitation due to leaflet prolapse? , 2009, The Annals of thoracic surgery.

[32]  A. Beckett,et al.  AKUFO AND IBARAPA. , 1965, Lancet.

[33]  Bart Meuris,et al.  Durability of mitral valve repair in Barlow disease versus fibroelastic deficiency. , 2008, The Journal of thoracic and cardiovascular surgery.

[34]  David H Adams,et al.  The cardiologist's role in increasing the rate of mitral valve repair in degenerative disease , 2008, Current opinion in cardiology.

[35]  Sean M. O'Brien,et al.  Predictors of mitral valve repair: clinical and surgeon factors. , 2010, The Annals of thoracic surgery.

[36]  T. Mihaljevic,et al.  Should patients with severe degenerative mitral regurgitation delay surgery until symptoms develop? , 2010, The Annals of thoracic surgery.

[37]  Patric Biaggi,et al.  Assessment of mitral valve prolapse by 3D TEE angled views are key. , 2011, JACC. Cardiovascular imaging.

[38]  J M Bland,et al.  Statistical methods for assessing agreement between two methods of clinical measurement , 1986 .

[39]  J. Carroll,et al.  A framework for systematic characterization of the mitral valve by real-time three-dimensional transesophageal echocardiography. , 2009, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[40]  B. Carabello,et al.  Valvular heart disease. , 1997, The New England journal of medicine.

[41]  A. Berrebi,et al.  Systolic anterior motion after mitral valve repair: an exceptional cause of late failure. , 2005, The Journal of thoracic and cardiovascular surgery.

[42]  Chung-Yi Chang,et al.  The routine use of live three-dimensional transesophageal echocardiography in mitral valve surgery: clinical experience. , 2010, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[43]  P. Noirhomme,et al.  Long-term survival in asymptomatic patients with severe degenerative mitral regurgitation: a propensity score-based comparison between an early surgical strategy and a conservative treatment approach. , 2009, The Journal of thoracic and cardiovascular surgery.

[44]  J. Fleiss,et al.  Intraclass correlations: uses in assessing rater reliability. , 1979, Psychological bulletin.

[45]  I. Kronzon,et al.  Utility of combined two-dimensional and three-dimensional transesophageal imaging for catheter-based mitral valve clip repair of mitral regurgitation. , 2011, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[46]  M. Enriquez-Sarano,et al.  Very Long-Term Survival and Durability of Mitral Valve Repair for Mitral Valve Prolapse , 2001, Circulation.