Mammalian methyltransferases and methyl-CpG-binding domains: proteins involved in DNA methylation.

[1]  A. Bird,et al.  The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites , 1999, Nature.

[2]  Paul Tempst,et al.  MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex , 1999, Nature Genetics.

[3]  E. Ballestar,et al.  Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation , 1999, Nature Genetics.

[4]  A. Bird,et al.  Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. , 1999, Genes & development.

[5]  V. Colot,et al.  Eukaryotic DNA methylation as an evolutionary device , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

[6]  M. Szyf,et al.  A mammalian protein with specific demethylase activity for mCpG DNA , 1999, Nature.

[7]  Peter A. Jones,et al.  Cancer-epigenetics comes of age , 1999, Nature Genetics.

[8]  T. Curran,et al.  Role of DNA 5-methylcytosine transferase in cell transformation by fos. , 1999, Science.

[9]  J. Jiricny,et al.  Eukaryotic mismatch repair: an update. , 1998, Mutation research.

[10]  Weidong Wang,et al.  NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. , 1998, Molecular cell.

[11]  D. Reinberg,et al.  The Dermatomyositis-Specific Autoantigen Mi2 Is a Component of a Complex Containing Histone Deacetylase and Nucleosome Remodeling Activities , 1998, Cell.

[12]  M Plachot,et al.  Chromosome methylation patterns during mammalian preimplantation development. , 1998, Genes & development.

[13]  A. Wolffe,et al.  A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase , 1998, Current Biology.

[14]  E. Li,et al.  Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases , 1998, Nature Genetics.

[15]  J. Strouboulis,et al.  Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription , 1998, Nature Genetics.

[16]  E. Li,et al.  Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. , 1998, Nucleic acids research.

[17]  Colin A. Johnson,et al.  Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex , 1998, Nature.

[18]  T. Bestor,et al.  Gene silencing: Methylation meets acetylation , 1998, Nature.

[19]  T. Bestor,et al.  Sex-specific exons control DNA methyltransferase in mammalian germ cells. , 1998, Development.

[20]  T. Bestor,et al.  A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast. , 1998, Human molecular genetics.

[21]  A. Wolffe,et al.  How does DNA methylation repress transcription? , 1997, Trends in genetics : TIG.

[22]  C. Hsieh.  Stability of patch methylation and its impact in regions of transcriptional initiation and elongation , 1997, Molecular and cellular biology.

[23]  S. Baylin.  Tying It All Together: Epigenetics, Genetics, Cell Cycle, and Cancer , 1997, Science.

[24]  H. Ng,et al.  Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. , 1997, Science.

[25]  M. Grunstein.  Histone acetylation in chromatin structure and transcription , 1997, Nature.

[26]  S. Cross,et al.  A component of the transcriptional represser MeCP1 shares a motif with DNA methyltransferase and HRX proteins , 1997, Nature Genetics.

[27]  M. Pazin,et al.  What's Up and Down with Histone Deacetylation and Transcription? , 1997, Cell.

[28]  Stefan U Kass,et al.  DNA methylation directs a time-dependent repression of transcription initiation , 1997, Current Biology.

[29]  A. Bird,et al.  MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin , 1997, Cell.

[30]  S. Baylin,et al.  New 5′ Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase* , 1996, The Journal of Biological Chemistry.

[31]  R. Jaenisch,et al.  Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[32]  R. Jaenisch,et al.  De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. , 1996, Development.

[33]  R. Jaenisch,et al.  DNA hypomethylation can activate Xist expression and silence X-linked genes. , 1996, Genes & development.

[34]  C. Tabin,et al.  Hox mutations au naturel , 1996, Nature Genetics.

[35]  R. Kolodner,et al.  Biochemistry and genetics of eukaryotic mismatch repair. , 1996, Genes & development.

[36]  R. Jaenisch,et al.  Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. , 1996, Genes & development.

[37]  D. Hornby,et al.  Activation of a yeast pseudo DNA methyltransferase by deletion of a single amino acid. , 1996, Journal of molecular biology.

[38]  A. Bird,et al.  The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse , 1996, Nature Genetics.

[39]  T. Kunkel,et al.  Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. , 1995, Cancer research.

[40]  R. Jaenisch,et al.  Loss of methylation activates Xist in somatic but not in embryonic cells. , 1995, Genes & development.

[41]  R. Boorstein,et al.  Oxidative damage to 5-methylcytosine in DNA. , 1995, Nucleic acids research.

[42]  A. Bird,et al.  Gene number, noise reduction and biological complexity. , 1995, Trends in genetics : TIG.

[43]  A. Bird,et al.  The fission yeast gene pmt1+ encodes a DNA methyltransferase homologue. , 1995, Nucleic acids research.

[44]  J. Herman,et al.  Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[45]  C. Hsieh,et al.  Dependence of transcriptional repression on CpG methylation density , 1994, Molecular and cellular biology.

[46]  A. Razin,et al.  DNA methylation and genomic imprinting , 1994, Cell.

[47]  H. Cedar,et al.  Role of DNA methylation in the regulation of transcription. , 1994, Current opinion in genetics & development.

[48]  Xiaodong Cheng,et al.  The DNA (cytosine-5) methyltransferases , 1994, Nucleic Acids Res..

[49]  A. Bird,et al.  Number of CpG islands and genes in human and mouse. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[50]  S. Kass,et al.  Inactive chromatin spreads from a focus of methylation , 1993, Molecular and cellular biology.

[51]  Rudolf Jaenisch,et al.  Role for DNA methylation in genomic imprinting , 1993, Nature.

[52]  A. Bird,et al.  Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. , 1993, Nucleic acids research.

[53]  M. Boguski,et al.  dbEST — database for “expressed sequence tags” , 1993, Nature Genetics.

[54]  C. Croce,et al.  Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[55]  T. Bestor,et al.  Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting. , 1992, Genes & development.

[56]  H. Leonhardt,et al.  A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei , 1992, Cell.

[57]  T. Bestor,et al.  Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. , 1992, The EMBO journal.

[58]  Rudolf Jaenisch,et al.  Targeted mutation of the DNA methyltransferase gene results in embryonic lethality , 1992, Cell.

[59]  A. Bird,et al.  Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA , 1992, Cell.

[60]  A. Riggs,et al.  X-chromosome inactivation and cell memory. , 1992, Trends in genetics : TIG.

[61]  A. Razin,et al.  Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. , 1992, Genes & development.

[62]  A. Bird,et al.  Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl‐CpG binding protein. , 1992, The EMBO journal.

[63]  A. Razin,et al.  Inhibition of promoter activity by methylation: possible involvement of protein mediators. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[64]  T. Dryja,et al.  Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. , 1991, American journal of human genetics.

[65]  B. Turner,et al.  Histone acetylation and control of gene expression. , 1991, Journal of cell science.

[66]  Adrian Bird,et al.  DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein , 1991, Cell.

[67]  M. Comb,et al.  CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2 , 1990, Nucleic Acids Res..

[68]  A. Bird,et al.  The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[69]  D. J. Driscoll,et al.  Sex difference in methylation of single-copy genes in human meiotic germ cells: Implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations , 1990, Somatic cell and molecular genetics.

[70]  J. Benhattar,et al.  Cytosine methylation in CTF and Sp1 recognition sites of an HSV tk promoter: effects on transcription in vivo and on factor binding in vitro. , 1989, Nucleic acids research.

[71]  R. Boorstein,et al.  Phylogenetic evidence of a role for 5-hydroxymethyluracil-DNA glycosylase in the maintenance of 5-methylcytosine in DNA. , 1989, Nucleic acids research.

[72]  A. Bird,et al.  Specific protection of methylated CpGs in mammalian nuclei , 1989, Cell.

[73]  A. Bird,et al.  Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs , 1989, Cell.

[74]  S. Iguchi-Ariga,et al.  CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. , 1989, Genes & development.

[75]  R J Roberts,et al.  Predictive motifs derived from cytosine methyltransferases. , 1989, Nucleic acids research.

[76]  V. Ingram,et al.  Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. , 1988, Journal of molecular biology.

[77]  F. Watt,et al.  Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter. , 1988, Genes & development.

[78]  W. Schaffner,et al.  Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated. , 1988, Genes & development.

[79]  S. Baylin,et al.  The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[80]  M. Karin,et al.  Cytosine methylation does not affect binding of transcription factor Sp1. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[81]  V. Chapman,et al.  Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. , 1987, Genes & development.

[82]  J. Jiricny,et al.  A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine , 1987, Cell.

[83]  A. Graessmann,et al.  Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[84]  S. Lehnert,et al.  Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. , 1987, Development.

[85]  M. Bulmer,et al.  Neighboring base effects on substitution rates in pseudogenes. , 1986, Molecular biology and evolution.

[86]  Howard Cedar,et al.  DNA methylation affects the formation of active chromatin , 1986, Cell.

[87]  A. Riggs,et al.  DNA methylation and gene function. , 1980, Science.

[88]  A. Bird.  DNA methylation and the frequency of CpG in animal DNA. , 1980, Nucleic acids research.

[89]  Philip J. Farabaugh,et al.  Molecular basis of base substitution hotspots in Escherichia coli , 1978, Nature.

[90]  W. Schnedl,et al.  5-Methylcytosine localised in mammalian constitutive heterochromatin , 1974, Nature.

[91]  G. R. Wyatt.  Occurrence of 5-Methyl-Cytosine in Nucleic Acids , 1950, Nature.

[92]  P. Modrich,et al.  Mismatch repair in replication fidelity, genetic recombination, and cancer biology. , 1996, Annual review of biochemistry.

[93]  A. Bird,et al.  Effects of DNA methylation on DNA-binding proteins and gene expression. , 1993, Current opinion in genetics & development.

[94]  P. Modrich,et al.  Mechanisms and biological effects of mismatch repair. , 1991, Annual review of genetics.

[95]  W. Doerfler,et al.  DNA methylation and gene activity. , 1983, Annual review of biochemistry.

[96]  T. Mohandas,et al.  DNA methylation and the control of gene expression on the human X chromosome. , 1983, Cold Spring Harbor symposia on quantitative biology.

[97]  T. Lindahl.  DNA repair enzymes. , 1982, Annual review of biochemistry.

[98]  W Arber,et al.  DNA modification and restriction. , 1969, Annual review of biochemistry.

[99]  A. Bird,et al.  Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins , 2022 .