论文信息 - Synthesis of New Pyrazolo[1.5.4-de]quinoxalines

Synthesis of New Pyrazolo[1.5.4-de]quinoxalines

New pyrazolo[1.5.4-de]quinoxaline derivatives were prepared by the action of 7-aminoindazole 1 on diethyl and dimethyl acetylene dicarboxylates. The structures of the obtained compounds and the direction of cyclization were investigated through a crystallographic study of compound 2. Further alkylation, hydrogenation, and bromination were also explored. The action of potassium thiocyanate on the obtained halo product led to a tetracyclic compound of 1.3-thiazolo[3.4-a]pyrazolo[1.5.4-de]quinoxaline series.

[1] E. Essassi,et al. Synthèse Facile de Nouvelles Thiazolo [3,4-a] Quinoxalines , 2010 .

[2] E. Essassi,et al. Synthèse et Étude de RMN1H en Présence de l'Eu (fod)3 des Pyrazolo[1,5,4‐ef] Benzodiazepine ‐1,5 Ones‐6(1) , 2010 .

[3] E. Essassi,et al. Reactions of 2-Pyrones with 7-Aminoindazole: The First Synthesis of N-(1H-7-Indazolyl)-pyridinones , 2008 .

[4] E. Essassi,et al. Reactivity of 7-Aminoindazole as a Bidendate Nucleophile , 2000 .

[5] E. Essassi,et al. Synthesis of New Heterocyclic Systems: Spirothiadiazolepyrazolo[1,5,4-ef][1,5]benzodiazepines. , 2000 .

[6] E. Essassi,et al. Synthesis of New Heterocyclic Systems:Spirothiadiazolepyrazolo[1,5,4-ef][1,5]benzodiazepines , 2000 .

[7] E. Essassi,et al. A New Way for the Synthesis of Pyrazolo-1,5-benzodiazepinethiones from 3,3-Dimercapto(or dialkylmercapto)-1-phenyl-2-propen-1-ones. , 2010 .

[8] Y. Okamoto,et al. A convenient synthesis of 3-formyl-2-oxo-1,2-dihydroquinoxaline chlorophenylhydrazones: Novel tautomeric equilibria between hydrazone imine and diazenyl enamine forms with long-range pSSrototropy , 1986 .

[9] Y. Okamoto,et al. A new method for the synthesis of novel 1-aryl-3-heteroaryl-1H-pyrazolo[3,4-b]quinoxalines , 1986 .