HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
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[1] C. Wykoff,et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis , 1999, Nature.
[2] Michael I. Wilson,et al. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation , 2001, Science.
[3] R. Conaway,et al. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[4] M. Ivan,et al. HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing , 2001, Science.
[5] M. Goldberg,et al. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. , 1988, Science.
[6] D. Smith,et al. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. , 1988, Gene.
[7] G. Semenza,et al. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. , 1995, Biochemical and biophysical research communications.
[8] B. Furie,et al. Vitamin K-Dependent Biosynthesis of γ-Carboxyglutamic Acid , 1999 .
[9] K. Aktories,et al. Bacterial protein toxins targeting rho GTPases. , 2000, FEMS microbiology letters.
[10] G. Semenza,et al. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. , 1999, Annual review of cell and developmental biology.
[11] M. Gassmann,et al. Induction of HIF–1α in response to hypoxia is instantaneous , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[12] G. Semenza. HIF-1 and mechanisms of hypoxia sensing. , 2001, Current opinion in cell biology.
[13] L. Huang,et al. Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway , 1998 .
[14] S. White,et al. Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein. , 2001, Cancer research.
[15] S. Takahashi,et al. Hypoxic Induction of Prolyl 4-Hydroxylase α(I) in Cultured Cells* , 2000, The Journal of Biological Chemistry.
[16] K. Kivirikko,et al. Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases. , 1998, Advances in enzymology and related areas of molecular biology.
[17] R. Roeder,et al. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. , 1983, Nucleic acids research.
[18] L. Poellinger,et al. Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein , 2000, The EMBO journal.
[19] W. Kaelin,et al. The von Hippel-Lindau tumor suppressor gene. , 2001, Experimental cell research.
[20] Eamonn R. Maher,et al. Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein* , 2000, The Journal of Biological Chemistry.
[21] M. Ivan,et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein , 2000, Nature Cell Biology.