Nanog-driven cell-reprogramming and self-renewal maintenance in Ptch1+/− granule cell precursors after radiation injury

[1]  A. Saran,et al.  Ex vivo miRNome analysis in Ptch1+/− cerebellum granule cells reveals a subset of miRNAs involved in radiation-induced medulloblastoma , 2016, Oncotarget.

[2]  Zhugang Wang,et al.  N-myc is a key switch regulating the proliferation cycle of postnatal cerebellar granule cell progenitors , 2015, Scientific Reports.

[3]  Tao-Sheng Li,et al.  Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice , 2015, Scientific Reports.

[4]  G. Hildebrandt,et al.  Low dose effects of ionizing radiation on normal tissue stem cells. , 2014, Mutation research. Reviews in mutation research.

[5]  F. Zindy,et al.  Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression. , 2013, Cancer research.

[6]  L. Di Marcotullio,et al.  microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1 , 2013, The EMBO journal.

[7]  Ke Chen,et al.  Understanding and targeting cancer stem cells: therapeutic implications and challenges , 2013, Acta Pharmacologica Sinica.

[8]  Mariateresa Mancuso,et al.  Dose and spatial effects in long-distance radiation signaling in vivo: implications for abscopal tumorigenesis. , 2013, International journal of radiation oncology, biology, physics.

[9]  P. Pelicci,et al.  DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions , 2013, Proceedings of the National Academy of Sciences.

[10]  P. Northcott,et al.  Molecular subgroups of medulloblastoma , 2012, Expert review of neurotherapeutics.

[11]  M. Peschanski,et al.  miR-125 potentiates early neural specification of human embryonic stem cells , 2012, Development.

[12]  Jane E. Visvader,et al.  Cells of origin in cancer , 2011, Nature.

[13]  Lin Zhang,et al.  Identification of MicroRNAs Regulating Reprogramming Factor LIN28 in Embryonic Stem Cells and Cancer Cells* , 2010, The Journal of Biological Chemistry.

[14]  A. Ruiz i Altaba,et al.  NANOG regulates glioma stem cells and is essential in vivo acting in a cross‐functional network with GLI1 and p53 , 2010, The EMBO journal.

[15]  Mauro Biffoni,et al.  Hedgehog controls neural stem cells through p53‐independent regulation of Nanog , 2010, The EMBO journal.

[16]  D. Meek.  Tumour suppression by p53: a role for the DNA damage response? , 2009, Nature Reviews Cancer.

[17]  Ge Guo,et al.  Nanog Is the Gateway to the Pluripotent Ground State , 2009, Cell.

[18]  A. Ruiz i Altaba,et al.  A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers , 2009, The EMBO journal.

[19]  M. Eilers,et al.  MYC increases self-renewal in neural progenitor cells through miz-1 , 2008, International Journal of Developmental Neuroscience.

[20]  I. Weissman,et al.  Wnt-mediated self-renewal of neural stem/progenitor cells , 2008, Proceedings of the National Academy of Sciences.

[21]  L. Karnitz,et al.  Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability , 2008, The Journal of cell biology.

[22]  Robert Machold,et al.  Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. , 2008, Cancer cell.

[23]  Shulan Tian,et al.  Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells , 2007, Science.

[24]  Austin G Smith,et al.  Nanog promotes transfer of pluripotency after cell fusion , 2006, Nature.

[25]  Yoav Mayshar,et al.  Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features , 2006, Development.

[26]  S. Pazzaglia,et al.  Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice , 2006, Oncogene.

[27]  F. Boussin,et al.  Radiation-Induced H2AX Phosphorylation and Neural Precursor Apoptosis in the Developing Brain of Mice , 2006, Radiation research.

[28]  Ligang Wu,et al.  Micro-RNA Regulation of the Mammalian lin-28 Gene during Neuronal Differentiation of Embryonal Carcinoma Cells , 2005, Molecular and Cellular Biology.

[29]  A. Joyner,et al.  In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog , 2005, Nature.

[30]  S. Morrison,et al.  Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. , 2005, Genes & development.

[31]  Alan Carleton,et al.  Sonic hedgehog controls stem cell behavior in the postnatal and adult brain , 2005, Development.

[32]  A. Joyner,et al.  Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development , 2004, Development.

[33]  V. Palma,et al.  Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex , 2003, Development.

[34]  G. Fishell,et al.  Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches , 2003, Neuron.

[35]  Cynthia Hawkins,et al.  Identification of a cancer stem cell in human brain tumors. , 2003, Cancer research.

[36]  J. Nichols,et al.  Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells , 2003, Cell.

[37]  S. Pazzaglia,et al.  High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice , 2002, Oncogene.

[38]  P. Sánchez,et al.  Gli and hedgehog in cancer: tumours, embryos and stem cells , 2002, Nature Reviews Cancer.

[39]  D. Kalderon,et al.  Hedgehog acts as a somatic stem cell factor in the Drosophila ovary , 2001, Nature.

[40]  A. Ruiz i Altaba,et al.  Sonic hedgehog regulates the growth and patterning of the cerebellum. , 1999, Development.

[41]  V. Wallace.  Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum , 1999, Current Biology.

[42]  L. Wojnowski,et al.  Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome , 1998, Nature Medicine.

[43]  M. Scott,et al.  Altered neural cell fates and medulloblastoma in mouse patched mutants. , 1997, Science.

[44]  F. Wulczyn,et al.  Lin28 and let-7: ancient milestones on the road from pluripotency to neurogenesis , 2014, Cell and Tissue Research.

[45]  O. Owoeye,et al.  Cerebellar reduction in rats by gamma irradiation is mitigated by pretreatment with methanolic extract of Vernonia amygdalina and alpha-tocopherol , 2010 .

[46]  P. Sánchez,et al.  HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity , 2007, Current Biology.

[47]  Fred H. Gage,et al.  Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo , 2003, Nature Neuroscience.

[48]  M. Scott,et al.  Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog , 1999, Neuron.