athologic Assessment of asculopathies in Pulmonary Hypertension

Pulmonary arterial hypertension (PAH) includes various forms of pulmonary hypertension of different etiology but similar clinical presentation and functional derangement. Histopathological vascular changes in all forms of PAH are qualitatively similar but with quantitative differences in the distribution and prevalence of pathological changes in various portions of the pulmonary vascular bed. The documentation of these topographic variations in the response of the pulmonary vasculature to injury may be important to understand the pathogenesis of the various subsets of PAH. To standardize the precise histopathological documentation of the pulmonary vasculopathy in PAH we propose a histopathological classification that includes both the predominant segment of the pulmonary vasculature affected and the possible coexistence of pathological changes in other vascular segments. (J Am Coll Cardiol 2004;43:25S–32S) © 2004 by the American College of Cardiology Foundation

[1]  M. Humbert,et al.  Pulmonary arterial hypertension , 2013, Orphanet Journal of Rare Diseases.

[2]  K. Meyer,et al.  Bronchoalveolar lavage as a diagnostic tool. , 2007, Seminars in respiratory and critical care medicine.

[3]  C. Wagenvoort,et al.  The pathology of pulmonary veno-occlusive disease , 2005, Virchows Archiv A.

[4]  K. Brown,et al.  Expression of human herpesvirus 8 in primary pulmonary hypertension. , 2003, The New England journal of medicine.

[5]  M. Frid,et al.  Mature Vascular Endothelium Can Give Rise to Smooth Muscle Cells via Endothelial-Mesenchymal Transdifferentiation: In Vitro Analysis , 2002, Circulation research.

[6]  A. Erbersdobler,et al.  Multifocal distribution of pulmonary capillary haemangiomatosis , 2002, Histopathology.

[7]  N. Voelkel,et al.  Microsatellite Instability of Endothelial Cell Growth and Apoptosis Genes Within Plexiform Lesions in Primary Pulmonary Hypertension , 2001, Circulation research.

[8]  P. Friedman,et al.  Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study. , 2000, American journal of respiratory and critical care medicine.

[9]  L. Crooks,et al.  Pulmonary capillary hemangiomatosis-like foci. An autopsy study of 8 cases. , 2000, American journal of clinical pathology.

[10]  R. L. Williams,et al.  Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth. , 1999, The American journal of pathology.

[11]  M. Humbert,et al.  Pulmonary edema complicating continuous intravenous prostacyclin in pulmonary capillary hemangiomatosis. , 1998, American journal of respiratory and critical care medicine.

[12]  K. Shroyer,et al.  Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. , 1998, The Journal of clinical investigation.

[13]  T. Yokoi,et al.  Pulmonary capillary hemangiomatosis : A unique feature of congestive vasculopathy associated with hypertrophic cardiomyopathy , 1998 .

[14]  F. Capron.  Lavage broncho-alvéolaire , 1997 .

[15]  D. Schraufnagel,et al.  Human alveolar capillaries undergo angiogenesis in pulmonary veno-occlusive disease. , 1996, The European respiratory journal.

[16]  R. Michel,et al.  Different distribution of plexiform lesions in primary and secondary pulmonary hypertension. , 1995, Human pathology.

[17]  V. S. Zhdanov,et al.  Pulmonary artery adventitial changes and venous involvement in primary pulmonary hypertension. , 1995, The American journal of pathology.

[18]  K. Moser,et al.  Pulmonary vascular lesions occurring in patients with chronic major vessel thromboembolic pulmonary hypertension. , 1993, Chest.

[19]  V. S. Zhdanov,et al.  [Pathology of primary pulmonary hypertension]. , 1993, Arkhiv patologii.

[20]  C W White,et al.  Treatment of pulmonary hemangiomatosis with recombinant interferon alfa-2a. , 1989, The New England journal of medicine.

[21]  S. Rich.  Primary pulmonary hypertension , 1988 .

[22]  J. Rouleau,et al.  Familial pulmonary capillary hemangiomatosis resulting in primary pulmonary hypertension. , 1988, Annals of internal medicine.

[23]  T. Colby,et al.  Pulmonary capillary hemangiomatosis. , 1985, The American review of respiratory disease.

[24]  T. Paavilainen,et al.  A case of pulmonary vascular occlusive disease: comparison of post‐mortem radiography and histology , 1985, Histopathology.

[25]  J. Spijker,et al.  Capillary haemangiomatosis of the lungs , 1978, Histopathology.

[26]  H. Ichinose,et al.  Pulmonary veno-occlusive disease: Report of a case with pseudoangiomatous features , 1977 .

[27]  D. Heath,et al.  Pulmonary veno-occlusive disease , 1971, Circulation.