Biomimetic apatite coatings on titanium coprecipitated with cephradine and salviae miltlorrhizae.

Incorporation of antibiotics in the apatite coatings on titanium surface is an effective step for surgical infections of titanium implant. In this work, antibiotics cephradine and traditional Chinese medicine salviae miltlorrhizae (SM) were incorporated in the simulated body fluid (SBF). The apatite coatings were coprecipitated with cephradine and SM by a biomimetic method. The research showed that in the biomimetic coprecipitation process cephradine containing carboxylic groups were beneficial to the apatite coprecipitation. X-ray diffraction patterns showed that cephradine had a positive effect on the crystal growth in terms of cystallinity. And also in the Fourier transformed infrared spectra, the organic groups corresponded with cephradine were also observed. However, little apatite formed on the titanium immersed in SBF with SM. Probably, SM was more absorbed on the surface when calcium and phosphate ions precipitated.

[1]  Tadashi Kokubo,et al.  How useful is SBF in predicting in vivo bone bioactivity? , 2006, Biomaterials.

[2]  De-an Guo,et al.  Simultaneous quantification of six major phenolic acids in the roots of Salvia miltiorrhiza and four related traditional Chinese medicinal preparations by HPLC-DAD method. , 2006, Journal of pharmaceutical and biomedical analysis.

[3]  Jinlan Zhang,et al.  Chemical fingerprint and metabolic fingerprint analysis of Danshen injection by HPLC-UV and HPLC-MS methods. , 2005, Journal of pharmaceutical and biomedical analysis.

[4]  P. Layrolle,et al.  Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[5]  P. Layrolle,et al.  Incorporation of tobramycin into biomimetic hydroxyapatite coating on titanium. , 2002, Biomaterials.

[6]  P. Ramesh,et al.  Microstructured microspheres of hydroxyapatite bioceramic , 2002, Journal of materials science. Materials in medicine.

[7]  Li He,et al.  Carbonate apatite coating on titanium induced rapidly by precalcification. , 2002, Biomaterials.

[8]  J. Tanaka,et al.  Effect of citric acid on the nucleation of hydroxyapatite in a simulated body fluid. , 1999, Biomaterials.

[9]  F. Cui,et al.  Low-temperature crystallization of calcium phosphate coatings synthesized by ion-beam-assisted deposition. , 1999, Journal of biomedical materials research.

[10]  G. Hastings,et al.  Titanium and titanium alloys , 1998 .

[11]  Jonathan Black,et al.  Handbook of Biomaterial Properties , 1998, Springer US.

[12]  G. H. Nancollas,et al.  Kinetics of nucleation and crystal growth of hydroxyapatite and fluorapatite on titanium oxide surfaces , 1997 .

[13]  F. Langlais,et al.  [Antibiotic release by tricalcic phosphate bone implantation. In vitro and in vivo pharmacokinetics of different galenic forms]. , 1997, Chirurgie; memoires de l'Academie de chirurgie.

[14]  S. Brouard,et al.  [Tricalcium phosphate, vector of antibiotics: gentamycin and vancomycin. In vitro physicochemical characterization, study of biomaterial porosity and gentamycin and vancomycin elution]. , 1997, Chirurgie; memoires de l'Academie de chirurgie.

[15]  A. Boskey,et al.  Matrix proteins and mineralization: an overview. , 1996, Connective tissue research.

[16]  T. Yotsuyanagi,et al.  Synthesis of antibiotic-loaded hydroxyapatite beads and in vitro drug release testing. , 1992, Journal of biomedical materials research.

[17]  T. Kokubo.  Recent progress in glass-based materials for biomedical applications , 1991 .

[18]  C. Klein,et al.  Plasma sprayed coatings of hydroxylapatite. , 1987, Journal of biomedical materials research.

[19]  R. Noort.  Titanium: The implant material of today , 1987 .

[20]  S. Weiner,et al.  Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization. , 1985, Proceedings of the National Academy of Sciences of the United States of America.